The Anti-Inflammatory and Immunomodulatory Activities of Natural Products to Control Autoimmune Inflammation

International Journal of Molecular Sciences, Год журнала: 2022, Номер 24(1), С. 95 - 95

Опубликована: Дек. 21, 2022

Inflammation is an integral part of autoimmune diseases, which are caused by dysregulation the immune system. This involves imbalance between pro-inflammatory versus anti-inflammatory mediators. These mediators include various cytokines and chemokines; defined subsets T helper/T regulatory cells, M1/M2 macrophages, activating/tolerogenic dendritic antibody-producing/regulatory B cells. Despite availability many anti-inflammatory/immunomodulatory drugs, severe adverse reactions associated with their long-term use often high costs impediments in effectively controlling disease process. Accordingly, suitable alternatives being sought for these conventional drugs. Natural products offer promising adjuncts/alternatives this regard. The specific compounds isolated from dietary/medicinal plant extracts have permitted rigorous studies on disease-modulating activities mechanisms involved therein. Here, we describe basic characteristics, action, preventive/therapeutic applications 5 well-characterized natural product (Resveratrol, Curcumin, Boswellic acids, Epigallocatechin-3-gallate, Triptolide). been tested extensively animal models autoimmunity as well limited clinical trials patients having corresponding diseases. We focused our description predominantly cell-mediated such rheumatoid arthritis, multiple sclerosis, Type 1 diabetes, ulcerative colitis, psoriasis.

Язык: Английский

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Plant Polyphenols and Their Potential Benefits on Cardiovascular Health: A Review

Molecules, Год журнала: 2023, Номер 28(17), С. 6403 - 6403

Опубликована: Сен. 1, 2023

Fruits, vegetables, and other food items contain phytochemicals or secondary metabolites which may be considered non-essential nutrients but have medicinal importance. These dietary exhibit chemopreventive therapeutic effects against numerous diseases. Polyphenols are found in fruits, grains. compounds several health benefits such as immune modulators, vasodilators, antioxidants. This review focuses on recent studies using polyphenols to treat cardiovascular disorders, atherosclerosis, vascular endothelium deficits. We focus exploring the safety of highly effective ensure their maximum impact cardiac abnormalities discuss epidemiological evidence intervention trials related these properties. Kaempferol, quercetin, resveratrol prevent oxidative stress by regulating proteins that induce oxidation heart tissues. In addition, modulate tone vessels releasing nitric oxide (NO) reducing low-density lipoprotein (LDL) atherosclerosis. cardiomyocytes, suppress expression inflammatory markers inhibit production inflammation exert an anti-inflammatory response. Consequently, diseases strokes, hypertension, failure, ischemic disease could prevented polyphenols.

Язык: Английский

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Development of Multifunctional Nanoencapsulated trans-Resveratrol/Chitosan Nutraceutical Edible Coating for Strawberry Preservation

ACS Nano, Год журнала: 2023, Номер 17(9), С. 8586 - 8597

Опубликована: Апрель 26, 2023

Phytochemical nanoencapsulation for nutrient delivery and edible coatings perishable food preservation are two emerging technologies. Leveraging the strong antimicrobial function of phytochemical nutrients, we propose convergent research to integrate technologies by embedding phytochemical-encapsulated nanoparticles in an coating on fresh fruits achieve multiple functions. In particular, report study strawberries that is composited trans-resveratrol (R)-encapsulated (RNPs) embedded a chitosan (CS) matrix. The biodegradable biocompatible RNPs significantly increased aqueous solubility R 150-fold bioavailability 3.5-fold after oral administration. Our results demonstrated abilities RNP-embedded CS diminish dehydration, prevent loss, inhibit microbe growth, increase nutraceutical value, preserve strawberry quality, extend shelf life during storage at both 22 4 °C. Such nanoencapsulation-based promising dual purposes enhancing preserving foods.

Язык: Английский

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The anticancer mechanism of action of selected polyphenols in triple-negative breast cancer (TNBC)

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 165, С. 115170 - 115170

Опубликована: Июль 21, 2023

Breast cancer is a leadingcause of cancer-related deaths in women globally, with triple-negative breast (TNBC) being an aggressive subtype that lacks targeted therapies and associated poor prognosis. Polyphenols, naturally occurring compounds plants, have been investigated as potential therapeutic strategy for TNBC. This review provides overview the anticancer effects polyphenols TNBC their mechanisms action. Several polyphenols, including resveratrol, quercetin, kaempferol, genistein, epigallocatechin-3-gallate, apigenin, fisetin, hesperetin luteolin, shown to inhibit cell proliferation, induce cycle arrest, promote apoptosis, suppress migration/invasion preclinical models. The molecular underlying involve modulation several signalling pathways, such PI3K/Akt, MAPK, STATT, NF-κB pathways. Polyphenols also exhibit synergistic chemotherapy drugs, making them promising candidates combination therapy. highlights clinical trials investigating use individually or therapy, against cancer. deepens under-standing mechanism action respective valuable insights into TNBC, lays groundwork future research this area.

Язык: Английский

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Halogenated Antimicrobial Agents to Combat Drug-Resistant Pathogens

Pharmacological Reviews, Год журнала: 2023, Номер 76(1), С. 90 - 141

Опубликована: Окт. 16, 2023

Antimicrobial resistance presents us with a potential global crisis as it undermines the abilities of conventional antibiotics to combat pathogenic microbes. The history antimicrobial agents is replete examples scaffolds containing halogens. In this review, we discuss impacts halogen atoms in various antibiotic types and their modes action, structure-activity relationships, contributions activity drug resistance. Other halogenated molecules, including carbohydrates, peptides, lipids, polymeric complexes, are also reviewed, effects on pharmacokinetics, pharmacodynamics, factors affecting antivirulence activities presented. Furthermore, halogenation circumvent rejuvenate impotent addressed. This review provides an overview significance halogenation, halogens interact biomolecular settings enhance pharmacological properties therapeutic usages preventing post-antibiotic era. Significance Statement increasing impotence critical threats health. roles importance have been established, but comparatively little known activities. first extensively evaluate classes provide overcome

Язык: Английский

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E-Stilbenes: General Chemical and Biological Aspects, Potential Pharmacological Activity Based on the Nrf2 Pathway

Pharmaceuticals, Год журнала: 2024, Номер 17(2), С. 232 - 232

Опубликована: Фев. 9, 2024

Stilbenes are phytoalexins, and their biosynthesis can occur through a natural route (shikimate precursor) or an alternative (in microorganism cultures). The latter is metabolic engineering strategy to enhance production due stilbenes recognized pharmacological medicinal potential. It believed that in the human body, these potential activities be modulated by regulation of nuclear factor erythroid derived 2 (Nrf2), which increases expression antioxidant enzymes. Given this, our review aims critically analyze evidence regarding E-stilbenes metabolism Nrf2 activation pathway, with emphasis on inflammatory oxidative stress aspects related pathophysiology chronic diseases. In this comprehensive literature review, it observed despite broad number stilbenes, those most frequently explored clinical trials preclinical studies vitro vivo) were resveratrol, piceatannol, pterostilbene, polydatin, stilbestrol, pinosylvin. some cases, depending dose/concentration chemical nature stilbene, was possible identify pathway. Furthermore, use experimental models presented challenge comparing results. view above, suggested have relationship whether directly indirectly, different biological pathways, diseases conditions mainly inflammation stress.

Язык: Английский

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Antimicrobial Activities of Natural Bioactive Polyphenols

Pharmaceutics, Год журнала: 2024, Номер 16(6), С. 718 - 718

Опубликована: Май 27, 2024

Secondary metabolites, polyphenols, are widespread in the entire kingdom of plants. They contain one or more hydroxyl groups that have a variety biological functions natural environment. These uses include polyphenols food, beauty products, dietary supplements, and medicinal products grown rapidly during past 20 years. Antimicrobial described together with their sources, classes, subclasses. Polyphenols found different such as dark chocolate, olive oil, red wine, almonds, cashews, walnuts, berries, green tea, apples, artichokes, mushrooms, etc. Examples benefits antiallergic, antioxidant, anticancer agents, anti-inflammatory, antihypertensive, antimicrobe properties. From these classes helpful for growth internal functional systems human body, providing healthy fats, vitamins, minerals, lowering risk cardiovascular diseases, improving brain health, rebooting our cellular microbiome health by mitochondrial uncoupling. Among various (curcumin, naringenin, quercetin, catechin, etc.) primarily antimicrobial activities discussed along possible future applications. For agents to be proven safe, adverse impacts must substantiated reliable scientific research well vitro vivo clinical data. Future may influenced this evaluation.

Язык: Английский

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Enhancing the Bioavailability of Resveratrol: Combine It, Derivatize It, or Encapsulate It?

Pharmaceutics, Год журнала: 2024, Номер 16(4), С. 569 - 569

Опубликована: Апрель 22, 2024

Overcoming the limited bioavailability and extensive metabolism of effective in vitro drugs remains a challenge that limits translation promising into clinical trials. Resveratrol, despite its well-reported therapeutic benefits, is not metabolically stable thus has been utilized as an drug. This because it needs to be consumed large amounts overcome burdens conversion less metabolites. Herein, we summarize more relevant approaches modify resveratrol, aiming increase biological efficacy. We discuss combination therapies, derivatization, use resveratrol nanoparticles. Interestingly, with established chemotherapeutic shown effects on colon cancer (with oxaliplatin), liver cisplatin, 5-FU), gastric doxorubicin). On other hand, derivatizing including hydroxylation, amination, amidation, imidation, methoxylation, prenylation, halogenation, glycosylation, oligomerization, differentially modifies could used for preferential outcomes. Moreover, encapsulation allows trapping within different forms shells targeted therapy. Depending nanoparticle used, can enhance solubility absorption, increasing These include polymers, metals, solid lipids, nanoparticles have preclinical results, adding “hype” research resveratrol. review provides platform compare allow directed better treatment options

Язык: Английский

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Unraveling the therapeutic efficacy of resveratrol in Alzheimer’s disease: an umbrella review of systematic evidence

Nutrition & Metabolism, Год журнала: 2024, Номер 21(1)

Опубликована: Март 19, 2024

Abstract Context Resveratrol (RV), a natural compound found in grapes, berries, and peanuts, has been extensively studied for its potential treating Alzheimer’s disease (AD). RV shown promise inhibiting the formation of beta-amyloid plaques (Aβ) neurofibrillary tangles (NFTs), protecting against neuronal damage oxidative stress, reducing inflammation, promoting neuroprotection, improving function blood–brain barrier (BBB). However, conflicting results have reported, necessitating comprehensive umbrella review systematic reviews to provide an unbiased conclusion on therapeutic effectiveness AD. Objective The objective this study was systematically synthesize evaluate meta-analysis investigating role AD using data from both human animal studies. Data sources extraction Of 34 examining association between that were collected, six included based specific selection criteria. To identify pertinent studies, search conducted English-language peer-reviewed journals without any restrictions publication date until October 15, 2023. carried out across multiple databases, including Embase, MEDLINE (PubMed), Cochrane Library, Web Science, Google Scholar, utilizing appropriate terms relevant research field. AMSTAR-2 ROBIS tools also used quality risk bias reviews, respectively. Two researchers independently extracted analyzed data, resolving discrepancies through consensus. note, adhered PRIOR checklist. analysis This presented robust evidence supporting positive impacts AD, irrespective mechanisms involved. It indeed indicated all unanimously concluded consumption can be effective treatment Conclusion exhibits promising benefiting individuals with various mechanisms. observed enhance cognitive function, reduce Aβ accumulation, protect BBB, support mitochondrial facilitate synaptic plasticity, stabilize tau proteins, mitigate neuroinflammation commonly associated Graphical abstract

Язык: Английский

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Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway

Biogerontology, Год журнала: 2024, Номер 25(4), С. 649 - 664

Опубликована: Апрель 9, 2024

Abstract Skin photoaging is mostly caused by ultraviolet A (UVA), although active medications to effectively counteract UVA-induced have not yet been created. Resveratrol, a naturally occurring polyphenol found in the skin of grapes, has shown various biological functions such as anti-inflammatory and antioxidant characteristics. However, role resveratrol clarified. We investigated mechanism action UVA irradiation human fibroblasts (HSF) innovatively modified mouse model photoaging. The results demonstrated that promoted AMP-activated protein kinase (AMPK) phosphorylation activate autophagy, reduce reactive oxygen species (ROS) production, inhibit apoptosis, restore normal cell cycle alleviate In addition, subcutaneous injection only improved symptoms roughness, erythema, increased wrinkles photodamaged mice, but also alleviated epidermal hyperkeratosis hyperpigmentation, reduced inflammatory responses, inhibited collagen fiber degradation. conclusion, our studies proved can treat elucidated possible molecular mechanisms involved, providing new therapeutic strategy for future anti-aging.

Язык: Английский

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