International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(19), С. 14577 - 14577
Опубликована: Сен. 26, 2023
The
eradication
of
cancer
stem
cells
(CSCs)
is
vital
to
successful
treatment
and
overall
disease-free
survival.
CSCs
are
a
sub-population
within
tumor
that
defined
by
their
capacity
for
continuous
self-renewal
recapitulation
new
tumors,
demonstrated
in
vitro
through
spheroid
formation.
Flavonoids
group
phytochemicals
with
potent
anti-oxidant
anti-cancer
properties.
This
paper
explores
the
impact
flavonoid
precursor
phloridzin
(PZ)
linked
ω-3
fatty
acid
docosahexaenoate
(DHA)
on
growth
MCF-7
paclitaxel-resistant
MDA-MB-231-TXL
breast
cell
lines.
Spheroid
formation
assays,
phosphatase
Western
blotting
were
performed
using
cells,
viability
Annexin-V-488/propidium
iodide
(PI)
staining,
7-aminoactinomycin
D
(7-AAD)
assays
cells.
PZ-DHA
significantly
reduced
formation,
as
well
metabolic
activity
vitro.
Treatment
also
suppressed
led
apoptosis.
did
not
have
an
observable
effect
expression
drug
efflux
transporters
ATP-binding
cassette
super-family
G
member
2
(ABCG2)
multidrug
resistance-associated
protein
1
(MRP1).
potential
avenue
chemo-resistant
possible
novel
CSC
therapy.
Future
pre-clinical
studies
should
explore
chemo-preventative
agent.
Phytomedicine,
Год журнала:
2024,
Номер
129, С. 155600 - 155600
Опубликована: Апрель 7, 2024
Breast
cancer
stands
as
the
most
common
malignancy
among
women
globally
and
a
leading
cause
of
cancer-related
mortality.
Conventional
treatments,
such
surgery,
hormone
therapy,
radiotherapy,
chemotherapy,
small-molecule
targeted
often
fall
short
addressing
complexity
heterogeneity
certain
breast
subtypes,
to
drug
resistance
metastatic
progression.
Thus,
search
for
novel
therapeutic
targets
agents
is
imperative.
Given
their
low
toxicity
abundant
variety,
natural
products
derivatives
are
increasingly
considered
valuable
sources
anticancer
drugs.
This
review
aims
elucidate
pharmacological
impacts
underlying
mechanisms
active
compounds
found
in
select
derivatives,
primarily
focusing
on
treatment.
It
intends
underscore
potential
these
substances
combating
guide
future
research
directions
development
product-based
therapeutics.
We
conducted
comprehensive
searches
electronic
databases
PubMed,
Web
Science,
Scopus
until
October
2023,
using
keywords
'breast
cancer',
'natural
products',
'derivatives',
'mechanism',
'signaling
pathways',
various
keyword
combinations.
The
presents
spectrum
phytochemicals,
including
but
not
limited
flavonoids,
polyphenols,
alkaloids,
examines
actions
animal
cellular
models
cancer.
effects
manifested
through
diverse
mechanisms,
induction
cell
death
via
apoptosis
autophagy,
suppression
tumor
angiogenesis.
An
increasing
array
proving
effective
against
Future
strategies
can
benefit
from
strategic
enhancement
properties
compounds,
optimization
action,
improved
bioavailability,
minimized
side
effects.
forthcoming
should
prioritize
facets
maximize
Abstract
Breast
cancer
is
a
complex
and
heterogeneous
disease,
encompassing
various
subtypes
characterized
by
distinct
molecular
features,
clinical
behaviors,
treatment
responses.
Categorization
of
based
on
the
presence
or
absence
estrogen
receptor
(ER),
progesterone
(PR),
human
epidermal
growth
factor
2
(HER2),
leading
to
such
as
luminal
A,
B,
HER2-positive,
triple-negative
breast
(TNBC).
TNBC,
comprising
around
20%
all
cancers,
lacks
expression
ER,
PR,
HER2
receptors,
rendering
it
unresponsive
targeted
therapies
presenting
significant
challenges
in
treatment.
TNBC
associated
with
aggressive
behavior,
high
rates
recurrence,
resistance
chemotherapy.
Tumor
initiation,
progression,
are
attributed
stem
cells
(BCSCs),
which
possess
self-renewal,
differentiation,
tumorigenic
potential.
Surface
markers,
self-renewal
pathways
(Notch,
Wnt,
Hedgehog
signaling),
apoptotic
protein
(Bcl-2),
angiogenesis
inhibition
(VEGF
inhibitors),
immune
modulation
(cytokines,
checkpoint
inhibitors)
among
key
targets
discussed
this
review.
However,
targeting
BCSC
subpopulation
presents
challenges,
including
off-target
effects,
low
solubility,
bioavailability
anti-BCSC
agents.
Nanoparticle-based
offer
promising
approach
target
cellular
processes
implicated
survival
BSCS
TNBC.
In
review,
we
explore
nanocarrier-based
approaches
for
BCSCs
aiming
overcome
these
improve
outcomes
patients.
These
nanoparticle-based
therapeutic
strategies
hold
promise
addressing
gap
delivering
while
minimizing
systemic
toxicity
enhancing
efficacy.
Graphical
abstract
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(10), С. 5569 - 5569
Опубликована: Май 20, 2024
Due
to
its
propensity
metastasize,
cancer
remains
one
of
the
leading
causes
death
worldwide.
Thanks
in
part
their
intrinsic
low
cytotoxicity,
effects
flavonoid
family
prevention
and
treatment
various
human
cancers,
both
vitro
vivo,
have
received
increasing
attention
recent
years.
It
is
well
documented
that
Apigenin
(4′,5,7-trihydroxyflavone),
among
other
flavonoids,
able
modulate
key
signaling
molecules
involved
initiation
cell
proliferation,
invasion,
metastasis,
including
JAK/STAT,
PI3K/Akt/mTOR,
MAPK/ERK,
NF-κB,
Wnt/β-catenin
pathways,
as
oncogenic
non-coding
RNA
network.
Based
on
these
premises,
aim
this
review
emphasize
some
events
through
which
suppresses
focusing
specifically
ability
target
molecular
pathways
angiogenesis,
epithelial-to-mesenchymal
transition
(EMT),
maintenance
stem
cells
(CSCs),
cycle
arrest,
death.
Expert Opinion on Drug Delivery,
Год журнала:
2024,
Номер
21(2), С. 229 - 244
Опубликована: Фев. 1, 2024
Introduction
Triple-negative
breast
cancer
(TNBC)
presents
unique
challenges
indiagnosis
and
treatment.Resveratrolexhibits
potential
as
a
therapeutic
intervention
for
TNBC
byregulating
various
pathways
such
the
PI3K/AKT,
RAS/RAF/ERK,
PKCδ,and
AMPK,
leading
to
apoptosis
through
ROS-mediated
CHOP
activationand
expression
of
DR4
DR5.
However,
clinical
efficacy
resveratrol
is
limited
due
itspoor
biopharmaceutical
characteristics
low
bioavailability
at
thetumor
site.
Nanotechnology
offers
promising
approach
improvingthe
achieveclinical
in
different
cancers.
Heliyon,
Год журнала:
2024,
Номер
10(11), С. e32390 - e32390
Опубликована: Июнь 1, 2024
A
form
of
cancer
that
affects
the
rectum
or
colon
(large
intestine)
is
called
colorectal
(CRC).
The
main
risk
factors
for
CRC
include
dietary,
lifestyle,
and
environmental
variables.
Currently
natural
polyphenols
have
demonstrated
impressive
anticarcinogenic
capabilities.
Pharmaceutics,
Год журнала:
2024,
Номер
16(2), С. 177 - 177
Опубликована: Янв. 26, 2024
Curcumin
is
a
natural
compound
that
has
been
widely
investigated
thanks
to
its
various
biological
properties,
including
antiproliferative.
This
molecule
acts
on
different
cancers
such
as
lung,
breast,
pancreatic,
colorectal,
etc.
However,
the
bioactive
actions
of
curcumin
have
limitations
when
physicochemical
properties
compromise
pharmacological
potential.
As
therapeutic
strategy
against
cancer,
associated
with
inorganic
nanoparticles.
These
nanocarriers
are
capable
delivering
and
offering
synergistically
enhance
anticancer
properties.
review
highlights
types
curcumin-based
nanoparticles
discusses
their
in
vivo
activity
models
cancer.
Heliyon,
Год журнала:
2024,
Номер
10(11), С. e31925 - e31925
Опубликована: Май 24, 2024
BackgroundBreast
cancer
is
a
major
global
cancer,
for
which
radiation
and
chemotherapy
are
the
main
treatments.
Natural
remedies
being
studied
to
reduce
side
effects.
Etoposide
(ETO),
chemo-drug,
quercetin
(QC),
phytochemical,
considered
potential
factors
adaptation
conventional
treatments.ObjectivesThe
anticancer
effect
of
synergy
between
ETO
Quercetin-loaded
solid
lipid
nanoparticles
(QC-SLNs),
was
investigated
in
MDA-MB-231
cells.MethodsWe
developed
QC-SLNs
efficient
cellular
delivery,
characterizing
their
morphology,
particle
size,
zeta
potential.
We
assessed
cytotoxicity
on
breast
cells
via
MTT
assay.
Effects
apoptosis
intensity
have
been
detected
utilizing
annexin
V-FITC,
PI,
caspase
activities.
Real-time
PCR
Bax
gene
Bcl-2
fold
change
expression,
while
Western
blot
analysis
determined
p53
p21
protein
levels.ResultsSpherical,
negatively
charged
QC-SLNs,
when
combined
with
ETO,
significantly
enhanced
inhibition
cell
proliferation
compared
or
alone.
The
treatment
also
notably
increased
pathway.
+
Bax/Bcl-2
ratio,
elevated
proteins,
activated
3
9
enzymes.
These
results
indicate
as
strategy
treatment,
potentially
overcoming
ETO-resistant
chemoresistance.ConclusionThese
suggest
that
QC-SLN
has
substantial
impact
cure
by
improving
efficacy
ETO.
This
enhancement
could
help
overcome
chemoresistance
observed
cancer.
