Psychogeriatrics,
Год журнала:
2023,
Номер
24(2), С. 473 - 495
Опубликована: Дек. 17, 2023
Abstract
Sarcopenia
causes
a
loss
of
skeletal
muscle
mass
and
decreases
strength
function.
Depressive
symptoms
are
common
cause
distress
among
geriatrics,
significantly
affecting
the
quality
life
older
adults.
Recently,
studies
have
shown
that
correlation
exists
between
sarcopenia
depression.
To
determine
prevalence
depressive
identify
factors
associated
with
sarcopenia,
we
systematically
searched
SCOPUS,
Science
Direct,
PubMed
databases
for
papers
on
published
from
2012
to
2022.
We
reviewed
literature
symptom
prevalence,
subjects
both
symptoms,
sarcopenia.
Only
cross‐sectional
were
included.
Nineteen
articles
met
inclusion
criteria
review,
overall
ranging
3.9%
41.7%.
The
was
reported
in
seven
studies,
8.09%
40%.
most
commonly
used
tools
diagnose
European
Working
Group
Older
People
consensus
Geriatric
Depression
Scale,
respectively.
Being
aged,
malnourished,
obese,
having
comorbidities
(hypertension
diabetes),
impaired
cognitive
function,
polypharmacy
found
be
been
adverse
health
outcomes
people.
Appropriate
nutritional
assessments
interventions
should
taken
manage
these
two
geriatric
conditions.
Further
planned,
considering
multidomain
intervention
strategies
improve
people's
mental
health.
npj Parkinson s Disease,
Год журнала:
2024,
Номер
10(1)
Опубликована: Авг. 28, 2024
Previous
observational
studies
suggested
that
sarcopenia
is
associated
with
Parkinson
disease
(PD),
but
it
unclear
whether
this
association
causal.
The
objective
of
study
was
to
examine
causal
associations
between
sarcopenia-related
traits
and
the
risk
or
progression
PD
using
a
Mendelian
randomization
(MR)
approach.
Two-sample
bidirectional
MR
analyses
were
conducted
evaluate
relationships.
Genome-wide
(GWAS)
summary
statistics
for
traits,
including
right
handgrip
strength
(n
=
461,089),
left
461,026),
appendicular
lean
mass
450,243),
retrieved
from
IEU
OpenGWAS
database.
GWAS
data
derived
FinnGen
database
(4235
cases;
373,042
controls).
Summary-level
PD,
Hoehn
Yahr
stage
3,
dementia,
development
levodopa-induced
dyskinesia,
obtained
recent
publication
on
in
4093
patients
12
longitudinal
cohorts.
Significant
identified
analysis
verified
through
polygenic
score
(PGS)-based
approach
pathway
enrichment
genotype
Parkinson's
Progression
Markers
Initiative.
results
supported
significant
influence
(odds
ratio
[OR]
0.152,
95%
confidence
interval
[CI]
0.055-0.423,
adjusted
P
0.0036)
(OR
0.597,
CI
0.440-0.810,
0.0111)
dyskinesia.
In
Cox
proportional
hazard
analysis,
higher
PGSs
(hazard
[HR]
0.225,
0.095-0.530,
0.0019)
(HR
0.303,
0.121-0.59,
0.0323)
significantly
lower
developing
after
adjusting
covariates.
Pathway
revealed
genome-wide
single-nucleotide
polymorphisms
substantially
enriched
biological
pathways
involved
control
synaptic
plasticity.
This
provides
genetic
evidence
protective
role
dyskinesia
PD.
Sarcopenia-related
can
be
promising
prognostic
markers
potential
therapeutic
targets
preventing
World Journal of Hepatology,
Год журнала:
2024,
Номер
16(2), С. 152 - 163
Опубликована: Фев. 27, 2024
The
prevalence
of
metabolic-associated
fatty
liver
disease
(MAFLD)
has
increased
substantially
in
recent
years
because
the
global
obesity
pandemic.
MAFLD,
now
recognized
as
number
one
cause
chronic
world,
not
only
increases
liver-related
morbidity
and
mortality
among
sufferers
but
also
worsens
complications
associated
with
other
comorbid
conditions
such
cardiovascular
disease,
type
2
diabetes
mellitus,
obstructive
sleep
apnoea,
lipid
disorders
sarcopenia.
Understanding
interplay
between
MAFLD
these
comorbidities
is
important
to
design
optimal
therapeutic
strategies.
Sarcopenia
can
be
either
part
process
that
results
(e.g.
,
or
adiposity)
a
consequence
especially
advanced
stages
fibrosis
cirrhosis.
worsen
by
reducing
exercise
capacity
production
various
muscle-related
chemical
factors.
Therefore,
it
crucial
thoroughly
understand
how
we
deal
diseases,
when
they
coexist.
We
explore
pathobiological
interlinks
sarcopenia
this
comprehensive
clinical
update
review
article
propose
evidence-based
strategies
enhance
patient
care.
Clinics and Practice,
Год журнала:
2024,
Номер
14(4), С. 1451 - 1467
Опубликована: Июль 25, 2024
Sarcopenia
is
a
multifactorial
age-related
disorder
that
causes
decrease
in
muscle
mass,
strength,
and
function,
leading
to
alteration
of
movement,
risk
falls,
hospitalization.
This
article
aims
review
recent
findings
on
the
factors
underlying
sarcopenia
strategies
required
delay
counteract
its
symptoms.
We
focus
molecular
linked
ageing,
role
low-grade
chronic
acute
inflammatory
conditions
such
as
cancer,
which
contributes
onset
sarcopenia,
clinical
criteria
for
diagnosis.
The
use
drugs
against
still
subject
debate,
suggested
approaches
restore
health
are
based
adequate
dietary
protein
intake
physical
exercise.
also
highlight
difference
amount
quality
amino
acids
within
animal-
plant-based
diets,
studies
have
often
shown
varying
results
regarding
their
effect
elderly
people.
In
addition,
many
reported
non-pharmacological
approaches,
an
optimization
training
programs
resistance
exercise,
can
be
effective
preventing
delaying
sarcopenia.
These
not
only
improve
maintenance
skeletal
but
reduce
care
costs
life
expectancy
The journal of nutrition health & aging,
Год журнала:
2024,
Номер
28(7), С. 100241 - 100241
Опубликована: Апрель 25, 2024
The
sarcopenia
(SI)
index,
defined
as
the
serum
creatinine
to
cystatin
C
ratio,
is
considered
a
predictor
of
poor
muscle
health
and
malnutrition,
which
related
major
adverse
cardiovascular
events.
However,
effect
SI
index
on
cognitive
function
in
stroke
patients
remains
unknown.
In
this
study,
we
aimed
examine
association
between
longitudinal
impairment
with
acute
ischemic
or
transient
attack.
Participants
who
met
inclusion
criteria
national,
multicenter,
prospective
cohort
study
were
enrolled
from
Impairment
Cognition
Sleep
(ICONS)
China
National
Stroke
Registry-3
(CNSR-3).
They
categorized
into
four
groups
according
quartile
index.
Cognitive
was
assessed
using
Montreal
Assessment
(MoCA)
scale.
Multivariable-adjusted
logistic
regression
models
performed
evaluate
post-stroke
(PSCI)
at
3-month
follow-up.
Moreover,
discrimination
tests
used
incremental
predictive
value
beyond
potential
risk
factors.
Furthermore,
subgroup
analyses
test
interactions.
Among
participants,
lower
was,
worse
performance.
At
follow-up,
participants
lowest
group
exhibited
42%
increase
relative
highest
[OR
0.58
(95%
CI
0.37–0.90)].
after
applying
test,
adding
factors
resulted
slight
improvement
predicting
[NRI
14%
(P
=
0.01)].
This
demonstrated
that
positively
associated
higher
prevalence
PSCI.
Monitoring
early
identification
treatment
individuals
low
level
may
be
helpful
reduce
impairment.
International Journal of Environmental Research and Public Health,
Год журнала:
2022,
Номер
19(8), С. 4723 - 4723
Опубликована: Апрель 14, 2022
Sarcopenia
is
a
condition
that
highly
prevalent
among
older
adults.
This
linked
to
numerous
adverse
health
outcomes,
including
cognitive
impairment
impairs
healthy
ageing.
While
sarcopenia
and
may
share
common
pathway,
limited
longitudinal
studies
exist
show
the
relationship
between
these
two
conditions.
Therefore,
this
study
aimed
examine
association
impairment.
cohort
adults
residing
in
Kuala
Pilah
District,
Negeri
Sembilan,
Malaysia.
There
were
2404
respondents
at
baseline
1946
one-year
follow-up.
Cognitive
was
determined
using
Mini-mental
State
Examination
scores.
identified
Asian
Working
Group
for
2019
criteria,
gait
speed
measured
4-meter
test,
handgrip
strength
assessed
Jamar
handheld
dynamometer,
appendicular
skeletal
muscle
mass
bioelectrical
impedance
analysis.
Generalized
estimating
equation
(GEE)
used
determine
impairment,
presented
as
relative
risk
(RR)
its
95%
confidence
interval.
The
prevalence
of
5.0%
(95%
CI
4.00–5.90),
severe
3.60%
2.84–4.31).
Upon
adjusting
covariates,
with
have
an
80
per
cent
increased
compared
those
without
(RR
1.80;
1.18–2.75).
Similarly,
found
significantly
increase
by
101
adjusted
model
2.01;
1.24–3.27).
Our
showed
sarcopenia,
low
physical
activity,
depressive
symptoms,
hearing
chronic
pain
associated
higher
community-dwelling
early
intervention
prevent
pain,
activity
recommended.
