A comprehensive review of recent advances in nanofiltration membranes for heavy metal removal from wastewater

Process Safety and Environmental Protection, Год журнала: 2022, Номер 189, С. 530 - 571

Опубликована: Дек. 1, 2022

Язык: Английский

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Revolutionizing soil heavy metal remediation: Cutting-edge innovations in plant disposal technology

The Science of The Total Environment, Год журнала: 2024, Номер 918, С. 170577 - 170577

Опубликована: Фев. 2, 2024

Язык: Английский

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Plant Foods and Their Bioactives as Dietary Enhancers for Colon Cancer Treatment with 5-Fluorouracil

Food Reviews International, Год журнала: 2025, Номер unknown, С. 1 - 50

Опубликована: Янв. 4, 2025

Cancer is the world's second most common cause of death, with colon cancer (CC) ranking third in prevalence and cancer-related fatalities. CC originates or rectum influenced by genetic mutations, lifestyle, diet. Although chemotherapy, especially 5-fluorouracil (5-FU), fundamental to treatment has improved patient survival, its benefits are often limited significant side effects emerging drug resistance. Recently, plant-based foods have drawn interest research for their natural bioactive compounds relatively low toxicity. Certain plant not only exhibit anti-cancer activity but may also boost effectiveness 5-FU while reducing adverse effects. Despite evidence suggesting a synergistic effect between 5-FU, this area remains fragmented. This review consolidates current on including fruits, vegetables, legumes, tea bioactives treatment. Besides, it explores mechanisms through which these enhance efficacy reduce effects, evaluates clinical application prospects, identifies challenges future directions. comprehensive analysis aims provide scientific foundation integrated CC, highlighting potential enhancing chemotherapy associated toxicities.

Язык: Английский

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A review of important heavy metals toxicity with special emphasis on nephrotoxicity and its management in cattle

Frontiers in Veterinary Science, Год журнала: 2023, Номер 10

Опубликована: Март 29, 2023

Toxicity with heavy metals has proven to be a significant hazard several health problems linked it. Heavy bioaccumulate in living organisms, pollute the food chain, and possibly threaten of animals. Many industries, fertilizers, traffic, automobile, paint, groundwater, animal feed are sources contamination metals. Few metals, such as aluminum (Al), may eliminated by elimination processes, but other like lead (Pb), arsenic (As), cadmium (Ca) accumulate body leading chronic toxicity Even if these have no biological purpose, their toxic effects still present some form that is damaging its appropriate functioning. Cadmium (Cd) Pb negative impacts on number physiological biochemical processes when exposed sub-lethal doses. The nephrotoxic Pb, As, Cd well known, high amounts naturally occurring environmental occupational populations exposures an adverse relationship between kidney damage metal exposure. Metal determined absorbed dosage, route exposure, duration whether acute or chronic. This can numerous disorders also result excessive due oxidative stress generated free radical production. concentration decreased through various procedures including bioremediation, pyrolysis, phytoremediation, rhizofiltration, biochar, thermal process. review discusses few mechanisms, cattle special emphasis kidneys.

Язык: Английский

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Phytochemicals Involved in Mitigating Silent Toxicity Induced by Heavy Metals

Foods, Год журнала: 2024, Номер 13(7), С. 978 - 978

Опубликована: Март 22, 2024

Heavy metals (HMs) are natural elements present in the Earth’s crust, characterised by a high atomic mass and density more than five times higher water. Despite their origin from sources, extensive usage processing of raw materials presence as silent poisons our daily products diets have drastically altered biochemical balance, making them threat to environment human health. Particularly, food chain polluted with toxic represents crucial route exposure. Therefore, impact HMs on health has become matter concern because severe chronic effects induced excessive levels body. Chelation therapy is an approved valid treatment for HM poisoning; however, despite efficacy demonstrated chelating agents, various dramatic side may occur. Numerous data demonstrate that dietary components phytoantioxidants play significant role preventing or reducing damage HMs. This review summarises phytochemicals, plant herbal extracts probiotics promoting mitigating different

Язык: Английский

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Hesperetin activates CISD2 to attenuate senescence in human keratinocytes from an older person and rejuvenates naturally aged skin in mice

Journal of Biomedical Science, Год журнала: 2024, Номер 31(1)

Опубликована: Янв. 23, 2024

Abstract Background CDGSH iron-sulfur domain-containing protein 2 (CISD2), a pro-longevity gene, mediates healthspan in mammals. CISD2 is down-regulated during aging. Furthermore, persistently high level of promotes longevity and ameliorates an age-related skin phenotype transgenic mice. Here we translate the genetic evidence into pharmaceutical application using potent activator, hesperetin, which enhances expression HEK001 human keratinocytes from older person. We also treated naturally aged mice order to study activator’s anti-aging efficacy. Methods studied biological effects hesperetin on aging using, firstly, cell-based platform, namely keratinocyte cell line established Secondly, used mouse model, old at 21-month old. In latter case, investigate efficacy ultraviolet B (UVB)-induced photoaging skin. identify underlying mechanisms potential pathways involved this process carried out transcriptomic analysis. Finally, knockdown Cisd2 knockout were Cisd2-dependent Results Four findings are pinpointed. Firstly , skin, mainly expressed proliferating epidermal basal layer and, furthermore, sun-exposed epidermis. Secondly person, mitochondrial function protects against reactive oxygen species-induced oxidative stress via increased expression; enhancement CISD2-dependent. Additionally, alleviates UVB-induced damage suppresses matrix metalloproteinase-1 expression, being major indicator keratinocytes. Thirdly analysis revealed that modulates panel differentially genes associated with function, redox homeostasis, inflammation attenuate senescence. Intriguingly, activates two known longevity-associated regulators, FOXO3a FOXM1, suppress senescence-associated secretory phenotype. Finally ameliorate occurs mechanism involving CISD2. Most strikingly, late-life treatment started lasting for 5 months, able retard rejuvenate Conclusions Our results reveal pharmacological elevation stage feasible approach effectively mitigating both intrinsic extrinsic could act as functional food or skincare product fighting

Язык: Английский

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Colonization of root endophytic fungus Serendipita indica improves drought tolerance of Pinus taeda seedlings by regulating metabolome and proteome

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Март 15, 2024

Pinus taeda is an important forest tree species for plantations because of its rapid growth and high yield oleoresins. Although P. distribute in warm wet southern China, drought, sometime serious long time, often occurs the region. To explore drought tolerance usage beneficial microorganisms, seedlings were planted pots inoculated with root endophytic fungus Serendipita indica finally treated stress 53 d. Metabolome proteome their needles analyzed. The results showed that S. inoculation under caused great changes levels some metabolites needles, especially flavonoids organic acids. Among them, eriocitrin, trans -aconitic acid, vitamin C, uric alpha-ketoglutaric A, stachydrine, coumalic itaconic calceolarioside B, 2-oxoglutaric citric acid upregulated more than three times stress, compared to those non-inoculated stress. KEGG analysis pathways enriched such as flavonoid biosynthesis, ascorbate aldarate metabolism, C5-branched dibasic metabolism. Proteome revealed specific differential proteins. Two proteins, namely, H9X056 H9VDW5, only appeared protein H9VNE7 was 11.0 In addition, increased enrichment water deficient-inducible proteins (such LP3-1, LP3-2, LP3-3, dehydrins) involved ribosomal structures A0A385JF23). Meanwhile, biosynthesis metabolism pathways, mainly including phenylpropanoid cutin, suberine wax 2-oxocarboxylic there positive relationships between accumulation Altogether, our metabolome provided a guideline further study functions related

Язык: Английский

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Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression

Neuroscience, Год журнала: 2025, Номер 569, С. 161 - 183

Опубликована: Фев. 7, 2025

Язык: Английский

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A combined DFT, Monte Carlo, and MD simulations of adsorption study of heavy metals on the carbon graphite (111) surface

Chemical Physics Impact, Год журнала: 2022, Номер 5, С. 100121 - 100121

Опубликована: Ноя. 5, 2022

This work investigated the adsorption mechanism of heavy metals: silver (Ag), mercury (Hg), cadmium (Cd), palladium (Pd), and zinc (Zn) on carbon graphite (111) surface based density functional theory (DFT), Metropolis Monte Carlo (MMC), molecular dynamics (MD) simulation methods. The obtained results from these species showed that process is spontaneous exothermic in nature. maximum capacities were neutral to low acid medium, interaction between Hg-carbon was more favored than other systems. These findings efficient removal studied metals. Moreover, this study better explains metals onto gives a theoretical basis for wider application adsorbent paper provides support various mediums also some new ideas secondary utilization quantum chemical descriptors

Язык: Английский

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Transmission of viruses and other pathogenic microorganisms via road dust: Emissions, characterization, health risks, and mitigation measures

Atmospheric Pollution Research, Год журнала: 2022, Номер 14(1), С. 101642 - 101642

Опубликована: Дек. 31, 2022

Язык: Английский

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