Pathology - Research and Practice, Год журнала: 2023, Номер 248, С. 154657 - 154657
Опубликована: Июль 1, 2023
Язык: Английский
Cancer Letters, Год журнала: 2023, Номер 570, С. 216307 - 216307
Опубликована: Июль 12, 2023
Язык: Английский
Процитировано
152
Seminars in Cancer Biology, Год журнала: 2023, Номер 88, С. 172 - 186
Опубликована: Янв. 1, 2023
Язык: Английский
Процитировано
85
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 158, С. 114204 - 114204
Опубликована: Янв. 4, 2023
Glioblastoma (GBM) is one of the most malignant cancers central nervous system and due to its sensitive location, surgical resection has high risk therefore, chemotherapy radiotherapy are utilized for treatment. However, chemoresistance radio-resistance other problems in GBM Hence, new therapies based on genes recommended treatment GBM. PTEN a tumor-suppressor operator cancer that inhibits PI3K/Akt/mTOR axis diminishing growth, metastasis drug resistance. In current review, function PTEN/PI3K/Akt progression evaluated. Mutation or depletion leads increase progression. Low expression level mediates poor prognosis by increasing proliferation invasion, promotes malignancy tumor cells. Moreover, loss signaling can result therapy resistance Activation impairs metabolism via glycolysis inhibition. contrast PTEN, PI3K/Akt oncogenic during progression, enhances. shows positive association with pathways similar signaling, regulated non-coding RNAs. upregulation inhibition anti-cancer agents be beneficial interfering This review emphasizes networks related provides insights targeting this effective
Язык: Английский
Процитировано
74
Pathology - Research and Practice, Год журнала: 2023, Номер 249, С. 154738 - 154738
Опубликована: Авг. 6, 2023
Язык: Английский
Процитировано
67
Medical Oncology, Год журнала: 2024, Номер 41(2)
Опубликована: Янв. 9, 2024
Язык: Английский
Процитировано
19
Clinical Medicine Insights Oncology, Год журнала: 2024, Номер 18
Опубликована: Янв. 1, 2024
Small extracellular vesicles called exosomes are produced by cells and contain a range of biomolecules, including proteins, lipids, nucleic acids. Exosomes have been implicated in the development spread cancer, recent studies shown that their contents may be exploited as biomarkers for early detection ongoing surveillance disease. In this review article, we summarize current knowledge on cancer. We discuss various methods used exosome isolation characterization, well different types biomolecules found within relevant cancer diagnosis prognosis. also highlight demonstrated utility exosomal such lung breast pancreatic Overall, show great promise noninvasive monitoring. ability to transform diagnostic therapeutic paradigms, providing more efficient individualized. This seeks serve an inspiration new ideas research never-ending fight against Moreover, further needed validate clinical establish standardized protocols analysis. With continued development, potential revolutionize treatment.
Язык: Английский
Процитировано
17
Experimental Cell Research, Год журнала: 2022, Номер 418(2), С. 113294 - 113294
Опубликована: Июль 20, 2022
Язык: Английский
Процитировано
61
Cell Death Discovery, Год журнала: 2022, Номер 8(1)
Опубликована: Авг. 13, 2022
Abstract Lung cancer has been one of the leading causes cancer-related death worldwide, and non-small-cell lung (NSCLC) accounts for majority morbidity, yet pathogenesis NSCLC not fully elucidated. Recently, long-chain non-coding RNA (lncRNA) attracted widespread attention. LncRNA is a type whose transcript length exceeds 200 nucleotides. After constant research, academics updated their understanding lncRNA, especially its role in biological processes cells, including epigenetic regulation, cell proliferation, differentiation. Notably, examination lncRNAs could serve as potential hallmarks clinicopathological features, long-term prognosis, drug sensitivity. Therefore, it necessary to explore functions lncRNA innovate strategies against based on lncRNA-related research. Herein, we reviewed occurrence, diagnosis, treatment, prognosis NSCLC, which only help promote comprehensive view but also shed light lncRNA-based diagnosis treatment NSCLC.
Язык: Английский
Процитировано
48
Cell Death and Disease, Год журнала: 2023, Номер 14(3)
Опубликована: Март 31, 2023
Abstract Non-small cell lung cancer (NSCLC) is one of the most threatening malignancies to human health and life. In cases, patients with NSCLC are already at an advanced stage when they diagnosed. recent years, has made great progress in precision therapy, but efficacy immunotherapy unstable, its response rate varies from patient patient. Several biomarkers have been proposed predict outcomes immunotherapy, such as programmed death-ligand 1 (PD-L1) expression tumor mutational burden (TMB). Nevertheless, detection assays invasive demanding on tissue. To effectively novel needed improve performance conventional biomarkers. Liquid biopsy capture detect circulating cells (CTCs), DNA (ctDNA) exosomes body fluids, blood, saliva, urine, pleural fluid cerebrospinal samples patients, so make analysis diagnosis other diseases. The application liquid provides a new possible solution, it several advantages non-invasive, real-time dynamic monitoring, overcoming heterogeneity. shown predictive value significantly improving treatment patients. Herein, we review predicting discuss challenges future directions this field.
Язык: Английский
Процитировано
36
Journal of Pharmaceutical and Biomedical Analysis, Год журнала: 2023, Номер 229, С. 115346 - 115346
Опубликована: Март 15, 2023
Язык: Английский
Процитировано
31