Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 248, P. 154657 - 154657
Published: July 1, 2023
Language: Английский
Cancer Letters, Journal Year: 2023, Volume and Issue: 570, P. 216307 - 216307
Published: July 12, 2023
Language: Английский
Citations
152
Seminars in Cancer Biology, Journal Year: 2023, Volume and Issue: 88, P. 172 - 186
Published: Jan. 1, 2023
Language: Английский
Citations
85
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 158, P. 114204 - 114204
Published: Jan. 4, 2023
Glioblastoma (GBM) is one of the most malignant cancers central nervous system and due to its sensitive location, surgical resection has high risk therefore, chemotherapy radiotherapy are utilized for treatment. However, chemoresistance radio-resistance other problems in GBM Hence, new therapies based on genes recommended treatment GBM. PTEN a tumor-suppressor operator cancer that inhibits PI3K/Akt/mTOR axis diminishing growth, metastasis drug resistance. In current review, function PTEN/PI3K/Akt progression evaluated. Mutation or depletion leads increase progression. Low expression level mediates poor prognosis by increasing proliferation invasion, promotes malignancy tumor cells. Moreover, loss signaling can result therapy resistance Activation impairs metabolism via glycolysis inhibition. contrast PTEN, PI3K/Akt oncogenic during progression, enhances. shows positive association with pathways similar signaling, regulated non-coding RNAs. upregulation inhibition anti-cancer agents be beneficial interfering This review emphasizes networks related provides insights targeting this effective
Language: Английский
Citations
74
Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 249, P. 154738 - 154738
Published: Aug. 6, 2023
Language: Английский
Citations
67
Medical Oncology, Journal Year: 2024, Volume and Issue: 41(2)
Published: Jan. 9, 2024
Language: Английский
Citations
19
Clinical Medicine Insights Oncology, Journal Year: 2024, Volume and Issue: 18
Published: Jan. 1, 2024
Small extracellular vesicles called exosomes are produced by cells and contain a range of biomolecules, including proteins, lipids, nucleic acids. Exosomes have been implicated in the development spread cancer, recent studies shown that their contents may be exploited as biomarkers for early detection ongoing surveillance disease. In this review article, we summarize current knowledge on cancer. We discuss various methods used exosome isolation characterization, well different types biomolecules found within relevant cancer diagnosis prognosis. also highlight demonstrated utility exosomal such lung breast pancreatic Overall, show great promise noninvasive monitoring. ability to transform diagnostic therapeutic paradigms, providing more efficient individualized. This seeks serve an inspiration new ideas research never-ending fight against Moreover, further needed validate clinical establish standardized protocols analysis. With continued development, potential revolutionize treatment.
Language: Английский
Citations
17
Experimental Cell Research, Journal Year: 2022, Volume and Issue: 418(2), P. 113294 - 113294
Published: July 20, 2022
Language: Английский
Citations
61
Cell Death Discovery, Journal Year: 2022, Volume and Issue: 8(1)
Published: Aug. 13, 2022
Abstract Lung cancer has been one of the leading causes cancer-related death worldwide, and non-small-cell lung (NSCLC) accounts for majority morbidity, yet pathogenesis NSCLC not fully elucidated. Recently, long-chain non-coding RNA (lncRNA) attracted widespread attention. LncRNA is a type whose transcript length exceeds 200 nucleotides. After constant research, academics updated their understanding lncRNA, especially its role in biological processes cells, including epigenetic regulation, cell proliferation, differentiation. Notably, examination lncRNAs could serve as potential hallmarks clinicopathological features, long-term prognosis, drug sensitivity. Therefore, it necessary to explore functions lncRNA innovate strategies against based on lncRNA-related research. Herein, we reviewed occurrence, diagnosis, treatment, prognosis NSCLC, which only help promote comprehensive view but also shed light lncRNA-based diagnosis treatment NSCLC.
Language: Английский
Citations
48
Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(3)
Published: March 31, 2023
Abstract Non-small cell lung cancer (NSCLC) is one of the most threatening malignancies to human health and life. In cases, patients with NSCLC are already at an advanced stage when they diagnosed. recent years, has made great progress in precision therapy, but efficacy immunotherapy unstable, its response rate varies from patient patient. Several biomarkers have been proposed predict outcomes immunotherapy, such as programmed death-ligand 1 (PD-L1) expression tumor mutational burden (TMB). Nevertheless, detection assays invasive demanding on tissue. To effectively novel needed improve performance conventional biomarkers. Liquid biopsy capture detect circulating cells (CTCs), DNA (ctDNA) exosomes body fluids, blood, saliva, urine, pleural fluid cerebrospinal samples patients, so make analysis diagnosis other diseases. The application liquid provides a new possible solution, it several advantages non-invasive, real-time dynamic monitoring, overcoming heterogeneity. shown predictive value significantly improving treatment patients. Herein, we review predicting discuss challenges future directions this field.
Language: Английский
Citations
36
Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2023, Volume and Issue: 229, P. 115346 - 115346
Published: March 15, 2023
Language: Английский
Citations
31