Current Status of Plant-Based Bioactive Compounds as Therapeutics in Alzheimer’s Diseases

Journal of Integrative Neuroscience, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 20, 2025

Alzheimer’s disease (AD) is a common central neurodegenerative disorder characterized primarily by cognitive impairment and non-cognitive neuropsychiatric symptoms that significantly impact patients’ daily lives behavioral functioning. The pathogenesis of AD remains unclear current Western medicines treatment are purely symptomatic, with singular pathway, limited efficacy, substantial toxicity side effects. In recent years, as research into has deepened, there been gradual increase in the exploration application medicinal plants for AD. Numerous studies have shown their active ingredients can potentially mitigate regulating various molecular mechanisms, including production aggregation pathological proteins, oxidative stress, neuroinflammation, apoptosis, mitochondrial dysfunction, neurogenesis, neurotransmission, brain-gut microbiota axis. this review, we analyzed comprehensively summarized advancements on AD, along underlying mechanisms clinical evidence. Ultimately, aimed to provide reference further investigation specific through which prevent treat well identification efficacious derived from plants.

Язык: Английский

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Jian Pi Hua Tan Fang Reverses Trastuzumab Resistance of HER2‐Positive Gastric Cancer Through PI3K/AKT/mTOR Pathway: Integrating Network Pharmacology, Molecular Docking and Experimental Validation

Immunity Inflammation and Disease, Год журнала: 2025, Номер 13(2)

Опубликована: Фев. 1, 2025

ABSTRACT Background Currently, trastuzumab resistance significantly impacts the treatment outcome for individuals with HER2‐positive gastric cancer. In clinical practice, Jian Pi Hua Tan Fang (JPHTF) has been shown to be effective in preventing recurrences and metastases caused by Yet, process remains unknown. We aim evaluate potential pharmacological mechanism of JPHTF interfering cancer (GC). Methods this study, network pharmacology molecular docking techniques were used forecast active ingredients, pathways, targets overcoming GC. Then, vitro models NCI‐N87/TR was developed, JPHTF‐containing serum utilized intervention confirm these crucial targets. Results Network showed that 92 compounds 420 therapeutic JPHTF. SRC, EGFR, TP53, AKT1 identified as main associated PI3K/Akt, MAPK, Ras playing roles angiogenesis, cell apoptosis, proliferation, chemotherapy GC microenvironment. Molecular analysis quercetin, formononetin, luteolin, which are exhibit high binding affinity central PI3K, AKT, mTOR. experiment, a significant alleviating effect on reversing apoptotic proliferation NCI‐N87/TR. Further biological experiments could regulate expression PI3K/AKT/mTOR pathway. Conclusion ability overcome NCI‐N87 cells through regulation

Язык: Английский

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Guhan Yangsheng Jing Mitigates Oxidative Stress and Ferroptosis to Improve Reproductive Damage in Diabetic Male Rats

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119746 - 119746

Опубликована: Апрель 1, 2025

Язык: Английский

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Comprehensive analysis of Hibisci mutabilis Folium extract’s mechanisms in alleviating UV-induced skin photoaging through enhanced network pharmacology and experimental validation

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Окт. 14, 2024

Background Skin photoaging induced by ultraviolet A (UVA) and B (UVB) radiation manifests as skin roughness, desquamation, pigmentation, wrinkle formation. Current treatments, such sunscreen, hormones, antioxidants, have limitations side effects. Traditional Chinese Medicine Hibisci Mutabilis Folium (HMF), or Mu-Fu-Rong-Ye in name, refers to the dried leaves of plant Hibiscus mutabilis L., which belongs Malvaceae family. It has been used traditionally treat acute mastitis, parotitis, neurodermatitis, burns. The reported activities HMF include anti-inflammatory anti-oxidant However, therapeutic potential preventing treating UV-induced remains unexplored. Objective This study aimed investigate protective effects extract (EHMF) against underlying mechanisms action, using network pharmacology experimental verification. Methods Network was employed identify effective chemical components EHMF. Potential targets were identified via PPI analysis. Representative compounds characterized UPLC-MS/MS. In vitro validation involved assessing HaCaT cell viability, observing live/dead staining through fluorescence microscopy, measuring inflammatory factors ELISA. For vivo validation, a mice model treated transdermally with EHMF Methotrexate daily for 7 days. Dermatitis severity, morphology, collagen fiber pathology evaluated. Inflammatory cytokine protein expression dorsal lesions confirmed Elisa Kits, Western blot immunohistochemistry. Results total 22 active ingredients identified. GO enrichment KEGG pathway analyses revealed focus on signaling pathways. experiments showed that significantly reduced cells improved survival rates. , alleviated back UV-exposed mice, reducing epidermal dermal thickening pathological infiltration. also decreased abnormal MMP-9 proliferation, along levels like TNF-α, IL-6, IL-17, EGFR. immunohistochemistry results indicated over-activation AKT-STAT3 inhibited. Conclusion effectively damage, inflammation, wrinkles, providing strong support its clinical application dermatological agent.

Язык: Английский

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Carrier-free immobilized enzyme for ligand fishing of carbonic anhydrase inhibitors in Salvia miltiorrhiza

Talanta, Год журнала: 2024, Номер 283, С. 127160 - 127160

Опубликована: Ноя. 4, 2024

Язык: Английский

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