Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

Molecules, Год журнала: 2023, Номер 28(4), С. 1845 - 1845

Опубликована: Фев. 15, 2023

Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical medicinal sections to promote human health prevent cure different diseases. The most common found nature anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, other sub-classes. impacts of plant phenolics on promoting diseases curing preventing antioxidant effects, antibacterial impacts, cardioprotective anticancer immune system promoting, anti-inflammatory skin protective effects from UV radiation. This work aims provide an overview phenolic as important sources medical application according recently published studies, well some interesting directions future research. keyword searches flavonoids, phenolics, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, secoiridoids were performed by using Web Science, Scopus, Google scholar, PubMed. acids contain a carboxylic acid group addition the basic structure mainly divided into hydroxybenzoic hydroxycinnamic acids. Hydroxybenzoic based C6-C1 skeleton often bound small organic acids, glycosyl moieties, or cell structural components. Common include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, salicylic Hydroxycinnamic C6-C3 also molecules such quinic glucose. main caffeic, p-coumaric, ferulic, sinapic

Язык: Английский

---

Plant Foods and Their Bioactives as Dietary Enhancers for Colon Cancer Treatment with 5-Fluorouracil

Food Reviews International, Год журнала: 2025, Номер unknown, С. 1 - 50

Опубликована: Янв. 4, 2025

Cancer is the world's second most common cause of death, with colon cancer (CC) ranking third in prevalence and cancer-related fatalities. CC originates or rectum influenced by genetic mutations, lifestyle, diet. Although chemotherapy, especially 5-fluorouracil (5-FU), fundamental to treatment has improved patient survival, its benefits are often limited significant side effects emerging drug resistance. Recently, plant-based foods have drawn interest research for their natural bioactive compounds relatively low toxicity. Certain plant not only exhibit anti-cancer activity but may also boost effectiveness 5-FU while reducing adverse effects. Despite evidence suggesting a synergistic effect between 5-FU, this area remains fragmented. This review consolidates current on including fruits, vegetables, legumes, tea bioactives treatment. Besides, it explores mechanisms through which these enhance efficacy reduce effects, evaluates clinical application prospects, identifies challenges future directions. comprehensive analysis aims provide scientific foundation integrated CC, highlighting potential enhancing chemotherapy associated toxicities.

Язык: Английский

---

Antimicrobial and antibiofilm activities of pomegranate peel phenolic compounds: Varietal screening through a multivariate approach

Journal of Bioresources and Bioproducts, Год журнала: 2023, Номер 8(2), С. 146 - 161

Опубликована: Янв. 14, 2023

Pomegranates are rich in phenolic compounds and known for their antioxidant, anti-inflammatory, anticancer properties. The highest concentration of these is found the peel (exocarp mesocarp), which constitutes about 50% whole fresh fruit. These bioactive phytochemicals exhibit a broad spectrum antimicrobial effects against both Gram-negative Gram-positive bacteria, as well fungi. In present paper, chemical composition activity mesocarp) from seven Punica granatum varieties (Wonderful, Mollar de Elche, Primosole, Sassari 1, 2, 3, Arbara Druci) grown Sardinia (Italy) were evaluated. Polar phenols, flavonoids, condensed tannins, anthocyanin contents evaluated by extraction with water at 20 40 °C. Orthogonal projections to latent structures discriminant analysis (OPLS-DA) was used characterize each variety according pomegranate extracts (PPEs). antibiofilm activities PPE further tested vitro Staphyloccocus aureus, Listeria monocytogenes, Salmonella bongori, Escherichia coli, Lacticaseibacillus casei Limosilactobacillus reuteri. species more sensitive than tested. Antimicrobial shown S. aureus L. monocytogenes strains, whereas less, even no bongori E. coli strains. PPEs 3 showed concentrations that varied 0.19 1.50 mg/mL, biofilm being reduced 70%. positively related punicalagin, flavonoid, chlorogenic acid content extracts. Finally, regarding pro-technological bacterial La. Li. reuteri very low, sensitivity specific high concentrations. This study proposes formulation extract valorizes agro-industrial waste context sustainability circular economy. Pomegranate should be considered potential sources natural, plant-derived antimicrobials, providing an alternative artificial products.

Язык: Английский

---

Anti-oxidant and anti-inflammatory effects of ellagic and punicic acid in an in vitro model of cardiac fibrosis

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 162, С. 114666 - 114666

Опубликована: Апрель 6, 2023

Cardiac fibrosis is a pathological process characterized by an excessive deposition of extracellular matrix (ECM) and increased production fibrillar collagen in the cardiac interstitium, mainly caused activation fibroblasts their transition into myofibroblasts. Oxidative stress deeply implicated pathogenesis both directly via its involvement tumor growth factor β1 (TGF-β1) signaling. Ellagic acid (EA) punicic (PA) are main components Punica granatum L (pomegranate) fruit seed oil respectively, whose antioxidant, anti-inflammatory anti-fibrotic effects have been previously described. Therefore, aim this study was to investigate EA or PA EA+PA vitro model fibrosis. Immortalized Human Fibroblasts (IM-HCF) were stimulated with 10 ng/ml TGF-β1 for 24 h induce fibrotic damage. Cells then treated (1 µM), µM) additional h. Both reduced pro-fibrotic proteins expressions intracellular reactive oxygen species (ROS) accumulation. The anti-oxidant activity also observed Nrf2 consequent TGF-β1-Smad2/3-MMP2/9 Wnt/β-catenin signaling inhibition, thus reducing production. significantly inhibit NF-κB pathway and, consequently, TNF-α, IL-1β IL-6 levels: greater effect when used combination. These results suggest that EA, particular might be effective through antioxidant properties modulation different molecular pathways.

Язык: Английский

---

An Overview of the Health Benefits, Extraction Methods and Improving the Properties of Pomegranate

Antioxidants, Год журнала: 2023, Номер 12(7), С. 1351 - 1351

Опубликована: Июнь 27, 2023

Pomegranate (

Язык: Английский

---

Preparation and characterization of gelatin-carboxymethylcellulose active film incorporated with pomegranate (Punica granatum L.) peel extract for the preservation of raspberry fruit

Food Hydrocolloids, Год журнала: 2023, Номер 150, С. 109677 - 109677

Опубликована: Дек. 26, 2023

Язык: Английский

---

Pomegranate (Punica granatum L.) phytochemicals target the components of metabolic syndrome

The Journal of Nutritional Biochemistry, Год журнала: 2024, Номер 131, С. 109670 - 109670

Опубликована: Май 19, 2024

Язык: Английский

---

Improved Cardiovascular Effects of a Novel Pomegranate Byproduct Extract Obtained through Hydrodynamic Cavitation

Nutrients, Год журнала: 2024, Номер 16(4), С. 506 - 506

Опубликована: Фев. 10, 2024

The healthy properties of pomegranate fruit, a highly consumed food, have been known for long time. However, the supply chain is still rather inefficient, with non-edible fraction, whose weight roughly half total and endowed plenty valuable bioactive compounds, either disposed or underutilized. A novel extract obtained from byproducts (called PPE), using hydrodynamic cavitation, green, efficient, scalable technique, was investigated its cardiovascular effects in vivo. PPE showed efficacy an acute phenylephrine (PE)-induced hypertensive rat model, similar to whole fruit (PFE) same extractive along good intestinal bioaccessibility after oral administration. Finally, when chronically administered 6 weeks spontaneously rats, shown significantly contain increase systolic blood pressure, comparable reference drug Captopril, at dose remarkably lower than reported effective ellagic acid. fraction also anti-inflammation anti-fibrotic effects. findings this study, extraction could contribute enhancing value chain, relieve related environmental burden, potentially improve public health.

Язык: Английский

---

Characterization of Bioactive Metabolites and Antioxidant Activities in Solid and Liquid Fractions of Fresh Duckweed (Wolffia globosa) Subjected to Different Cell Wall Rupture Methods

ACS Omega, Год журнала: 2024, Номер 9(18), С. 19940 - 19955

Опубликована: Апрель 23, 2024

Fresh

Язык: Английский

---

The role of the natural compound naringenin in AMPK-mitochondria modulation and colorectal cancer inhibition

Phytomedicine, Год журнала: 2024, Номер 131, С. 155786 - 155786

Опубликована: Май 28, 2024

Although AMP-activated protein kinase (AMPK) has been extensively studied in cellular processes, the understanding of its substrates, downstream functions, contributions to cell fate and colorectal cancer (CRC) progression remains incomplete.

Язык: Английский

---