Advancements in nanotechnology for the delivery of phytochemicals

Journal of Integrative Medicine, Год журнала: 2024, Номер 22(4), С. 385 - 398

Опубликована: Апрель 24, 2024

Язык: Английский

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Natural essential oils as a new therapeutic tool in colorectal cancer

Cancer Cell International, Год журнала: 2022, Номер 22(1)

Опубликована: Дек. 13, 2022

Colorectal cancer (CRC) is the third most revalent type of in world and second common cause death (about 1 million per year). Historically, natural compounds their structural analogues have contributed to development new drugs useful treatment various diseases, including cancer. Essential oils are odorous products made up a complex mixture low molecular weight with recognized biological pharmacological properties investigated also for prevention The aim this paper highlight possible role essential CRC, composition preclinical studies involving them. It has been reviewed determine experimental models used anticancer potential mechanisms action CRC. Searches were performed following databases PubMed/Medline, Web science, TRIP database, Scopus, Google Scholar using appropriate MeSH terms. results analyzed showed that EOs exhibited wide range bioactive effects like cytotoxicity, antiproliferative, antimetastatic on cells through action. This updated review provides better quality scientific evidence efficacy as chemotherapeutic/chemopreventive agents Future translational clinical needed establish effective dose humans well suitable route administration maximum bioavailability efficacy. Given positive obtained from studies, can be considered efficient complementary therapies chemotherapy

Язык: Английский

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A comprehensive review on traditional uses, phytochemistry and pharmacological properties of Paeonia emodi Wall. ex Royle: current landscape and future perspectives

Chinese Medicine, Год журнала: 2023, Номер 18(1)

Опубликована: Март 2, 2023

Abstract Paeonia emodi Wall. ex Royle is commonly known as Himalayan paeony has great importance a food and medicine. The practice of very ancient it conventionally used for wide range illnesses in the folk system medicine because its beneficial phytochemical profile. main purpose current review was synthesis recent data on botany, ethnopharmacology, phytochemistry potential pharmacological mechanisms action Royle, thus offering new prospects development adjuvant natural therapies. Using scientific databases such PubMed/MedLine, Scopus, Web Science, ScienceDirect, Google Scholar, Springer, Wiley, comprehensive literature search performed Royle. For searching, we next MeSH terms: “Biological Product/isolation purification”, Products/pharmacology”, “Drug Discovery/methods”, “Ethnopharmacology, Medicine”, “Traditional/methods”, “Paeonia/chemistry”, “Plant Extracts/pharmacology”, “Phytochemicals/chemistry”, “Phytochemicals/pharmacology”, “Plants, Medicinal”. results most studies were analyzed important summarized tables figures. Phytochemical research led to isolation triterpenes, monoterpenes, phenolic acids, fatty organic compounds, steroids, free radicals some other classes primary metabolites. In addition, diverse activities like antibacterial, antifungal, anticoagulant, airway relaxant lipoxygenase beta-glucuronidase inhibiting activity, radical scavenging phytotoxic insecticidal have been reported Different bioactive compounds proven their therapeutic modern biomedical cure numerous gastrointestinal nervous disorders. future, further vitro vivo are required identify action, pharmacokinetics studies, pharmaceutical formulations target transport possible interaction with allopathic drugs. Also, regarding quality evaluation, toxicity safety humans needed.

Язык: Английский

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Neuroprotective, Anti-Inflammatory and Antifibrillogenic Offerings by Emodin against Alzheimer’s Dementia: A Systematic Review

ACS Omega, Год журнала: 2024, Номер unknown

Опубликована: Фев. 7, 2024

Background: Alzheimer's disease (AD) is among the major causes of dementia in elderly and exerts tremendous clinical, psychological socio-economic constraints. Currently, there are no effective disease-modifying/retarding anti-AD agents. Emodin a bioactive phytochemical with potent multimodal anti-inflammatory, antioxidant, antifibrillogenic properties. In particular, emodin may result significant repression pathogenic mechanisms underlying AD. The purpose this review to accumulate summarize all primary research data evaluating therapeutic actions AD pathogenesis. Methodology: search, selection, retrieval pertinent articles were systematically performed using methodically designed approach. A variety keyword combinations employed on online scholarly web-databases. Strict preset inclusion exclusion criteria used select retrieved studies. Data from individual studies summarized compiled into different sections, based upon their findings. Results: Cellular animal indicates that robust neuroprotection While effectively prevents tau amyloid-beta (Aβ) oligomerization, it also mitigates neurotoxicity by attenuating neuroinflammatory, oxidative, bioenergetic defects. Evidences for emodin-mediated enhancements memory, learning, cognition found literature. Conclusion: potential dietary supplement; however, further warrantied thoroughly understand its target players mechanisms. Moreover, human clinical amelioration phenotype largely lacking, must be addressed future. Lastly, safety exogenously supplemented evaluated.

Язык: Английский

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Proteoglycan Dysfunction: A Common Link Between Intervertebral Disc Degeneration and Skeletal Dysplasia

Neurospine, Год журнала: 2024, Номер 21(1), С. 162 - 178

Опубликована: Март 28, 2024

Proteoglycans through their sulfated glycosaminoglycans regulate cell-matrix signaling during tissue development, regeneration, and degeneration processes. Large extracellular proteoglycans such as aggrecan, versican, perlecan are especially important for the structural integrity of intervertebral disc cartilage development. In these tissues, responsible hydration, joint flexibility, absorption mechanical loads. Loss or reduction molecules can lead to skeletal dysplasia, evident from loss height defects in development respectively. this review, we discuss common found elaborate on various murine models dysplasias humans highlight how absence and/or aberrant expression causes accelerated developmental defects.

Язык: Английский

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Key oncologic pathways inhibited by Erinacine A: A perspective for its development as an anticancer molecule

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 160, С. 114332 - 114332

Опубликована: Фев. 1, 2023

In the modern era, cancer can be controlled by chemotherapy treatment, and in many situations a stable disease is obtained. The significant clinical success subsequent commercialization of naturally derived molecules have further encouraged their exploration as adjunctive therapies management. purpose this comprehensive review to update anticancer mechanisms triggered Erinacine A regulation signaling pathways potentially involved its activity.The results preclinical research showed that Erinacin A, therapeutically important biological metabolite isolated from basidiomycete fungus Hericium erinaceus offers multitude possible chemotherapeutic applications regulating complex validated various pharmacological vitro vivo studies. As result A's action on oncological pathways, it resulted induction apoptosis, reduction proliferation, invasiveness, generation oxidative stress cell cycle arrest cells.

Язык: Английский

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Library-based UHPLC-Q-exactive-orbitrap-MS putative identification of isomeric and non-isomeric bioactives from Zibushengfa Tablet and pharmacopeia quality-marker chemistry

Journal of Liquid Chromatography &amp Related Technologies, Год журнала: 2023, Номер 46(6-10), С. 153 - 167

Опубликована: Июнь 21, 2023

Zibushengfa Tablet is a widely consumed traditional Chinese medicine (TCM) prescription. However, its main bioactives remain unclear and pharmacopeia quality-marker (Q-marker) poorly characterized nowadays. The present study analyzed lyophilized aqueous powder using ultra-high-performance liquid chromatography-quadrupole-orbitrap mass spectrometry. Through comparison with authentic standards in the library, 46 were putatively identified, including quinic acid, D-gluconic gallic protocatechuic 5-caffeoylquinic L-tryptophan, salidroside, (+)-catechin hydrate, caffeic cryptochlorogenic mangiferin, ferulic myricetin-3-O-galactoside, 2,3,5,4'-tetrahydroxystilbene-2-O-glucoside, forsythoside B, myricitrin, rutin, hyperoside, acteoside, 3,4-dicaffeoylquinic myricetin, senkyunolide A, isochlorogenic acid C, quercitrin, (+)-epipinoresinol, quercetin, biochanin calycosin, luteolin, wedelolactone, calycosin-7-O-glucoside, chrysoeriol, trans-cinnamic formononetin, chrysin, 3,3',4',5,6,7,8-heptamethoxyflavone, Z-ligustilide, amentoflavone, tangeretin, hinokiflavone, emodin, physcion, linoleic stearic palmitic ethyl ester. Of these, four pairs of isomers successfully differentiated newly established library-filtering strategy. On this basis, wedelolactone are preliminarily suggested as additional quality-markers for consideration by Pharmacopeia Committee, to prevent possible adulterate.

Язык: Английский

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Emodin Ameliorates Severe Acute Pancreatitis-Associated Acute Lung Injury in Rats by Modulating Exosome-Specific miRNA Expression Profiles

International Journal of Nanomedicine, Год журнала: 2023, Номер Volume 18, С. 6743 - 6761

Опубликована: Ноя. 1, 2023

Background: Numerous preclinical investigations have exhibited the beneficial impact of emodin (EMO) on management severe acute pancreatitis (SAP)-associated lung injury (ALI). However, potential EMO to mitigate organ damage through modulation exosome (Exo)-specific miRNA expression profiles remains unclear. Methods: The SAP rat model was established by retrograde injection 5% sodium taurocholate into pancreatic bile duct. Rats received intragastric administration at 2 h and 12 post-modeling. Plasma bronchoalveolar lavage fluid (BALF)-derived exosomes were isolated purified from rats treated with EMO. therapeutic effects these Exos in assessed using hematoxylin-eosin staining measurement inflammatory factor levels. MicroRNA (miRNA) sequencing conducted plasma BALF-derived Exos, rescue experiments performed investigate function NOVEL miR-29a-3p treatment Results: exhibits ameliorative inflammation SAP. Plasma/BALF-derived EMO-treated also rats. profile underwent significant changes upon exposure In particular, 34 differentially expressed miRNAs (DEmiRNAs) identified when comparing BALF-SAP+EMO-Exo BALF-SAP-Exo. 39 DEmiRNAs plasma-SAP+EMO-Exo plasma-SAP-Exo. We found that derived BALF a more potent response than those plasma. may rely NOVEL-rno-miR-29a-3p prevent pulmonary Conclusion: mechanism action is observed NOVEL-rno-miR-29a-3p, which specific BALF, play crucial role efficacy Plain Language Summary: Exosomes extracted plasma/BALF show substantial SAP-Associated ALI, having higher effect plasma-derived exosomes.EMO dramatically altered patterns rats.The protective somewhat reliant Novel-rno-miR-29a-3p expression. Keywords: pancreatitis, injury, emodin, exosome, microRNA

Язык: Английский

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Polyporus umbellatus, A Precious Rare Fungus With Good Pharmaceutical and Food Value

Engineering in Life Sciences, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 1, 2025

ABSTRACT Polyporus umbellatus is a rare porous fungus that exhibits notable pharmacological activities. Particularly, due to its diuretic properties, it considered an important source of targeted drugs for the treatment kidney disease. Extensive research has been conducted on this fungus, focusing not only challenging cultivation techniques but also diverse array medicinal ingredients, including polysaccharides and steroids. These active compounds demonstrate considerable variability exhibit wide range properties. As result, extracting, separating, purifying these become subject interest. This review aims provide comprehensive overview types, structures, physicochemical properties compounds. Additionally, effects P. are thoroughly examined, offering valuable insights into utilization resources rational development medical fungi.

Язык: Английский

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Plant-derived compounds with antineoplastic activity: a literature review

Caderno Pedagógico, Год журнала: 2025, Номер 22(1), С. e13488 - e13488

Опубликована: Янв. 20, 2025

Natural products, especially those derived from plants used in traditional medicine, are a significant source of novel therapeutics. Numerous plant-derived molecules have been extensively documented scientific literature for their potential antineoplastic effects, acting through various mechanisms. This review highlights the most frequently cited compounds over past 12 years: emodin, genistein, luteolin, parthenolide, quercetin, resveratrol, and betulinic acid. The aim is to provide an overview these compounds, plant origins, mechanisms action. Studies were selected PubMed, SciELO, LILACS, Google Scholar databases using DeCS/MeSH descriptors relevant guiding question. All included studies evaluated antitumor activity experiments reported literature, demonstrating efficacy against different cancer cell lines. exhibited cytotoxic pro-apoptotic activities, inhibited viability, proliferation, migration, reduced resistance existing drugs. These findings illustrate anticancer pharmacological under investigation highlight necessity further clinical on facilitate future application therapy.

Язык: Английский

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