Journal of Cosmetic Dermatology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 22, 2024
Melasma, also known as chloasma, is a common skin disorder characterized by acquired hyperpigmentation. Many patients with this condition prefer using herbal remedies instead of chemical agents. This study aims to review clinical trials conducted on the effectiveness in treating melasma.
Язык: Английский
Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)
Опубликована: Янв. 2, 2024
Abstract Cancer remains a significant global public health concern, with increasing incidence and mortality rates worldwide. Oxidative stress, characterized by the production of reactive oxygen species (ROS) within cells, plays critical role in development cancer affecting genomic stability signaling pathways cellular microenvironment. Elevated levels ROS disrupt homeostasis contribute to loss normal functions, which are associated initiation progression various types cancer. In this review, we have focused on elucidating downstream that influenced oxidative stress carcinogenesis. These include p53, Keap1-NRF2, RB1, p21, APC, tumor suppressor genes, cell type transitions. Dysregulation these can lead uncontrolled growth, impaired DNA repair mechanisms, evasion death, all hallmark features development. Therapeutic strategies aimed at targeting emerged as area investigation for molecular biologists. The objective is limit response time cancer, including liver, breast, prostate, ovarian, lung cancers. By modulating redox balance restoring homeostasis, it may be possible mitigate damaging effects enhance efficacy treatments. targeted therapies interventions specifically address impact holds great promise improving patient outcomes. approaches antioxidant-based treatments, redox-modulating agents, restore function affected stress. summary, understanding carcinogenesis process through therapeutic utmost importance combating Further research needed unravel complex mechanisms underlying stress-related develop effective translated into clinical applications management treatment
Язык: Английский
Процитировано
119
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 162, С. 114687 - 114687
Опубликована: Апрель 14, 2023
Cancer is still the leading cause of death worldwide, burdening global medical system. Rosmarinic acid (RA) among first secondary metabolites discovered and it a bioactive compound identified in plants such as Boraginaceae Nepetoideae subfamilies Lamiaceae family, including Thymus masticmasti chinaythia koreana, Ocimum sanctum, Hyptis pectinate. This updated review to highlight chemopreventive chemotherapeutic effects RA its derivatives, thus providing valuable clues for potential development some complementary drugs treatment cancers. Relevant information about RA's derivatives were collected from electronic scientific databases, PubMed/Medline, Scopus, TRIP database, Web Science, Science Direct. The results studies showed numerous significant biological antiviral, antibacterial, anti-inflammatory, anti-tumour, antioxidant antiangiogenic effects. Most on anticancer with corresponding mechanisms are experimental preclinical stage missing evidence clinical trials support research. To open new therapeutic perspectives future must elucidate molecular targets action more detail, human toxic adverse
Язык: Английский
Процитировано
65
Cell Communication and Signaling, Год журнала: 2023, Номер 21(1)
Опубликована: Май 1, 2023
Abstract Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has crucial role in cytoprotective response against stress, including cancer growth progression therapy resistance. For this reason, inhibitors are new targets to be studied. Traditional plant-based remedies rich phytochemicals have been used human cancers phenolic compounds known for their chemopreventive properties. This comprehensive review offers updated the as anticancer agents due action on inhibition. In addition, naturally-occurring bioactive covered clinical applications polyphenols inhibitors.
Язык: Английский
Процитировано
53
Process Biochemistry, Год журнала: 2024, Номер 144, С. 112 - 132
Опубликована: Май 24, 2024
Язык: Английский
Процитировано
22
Antioxidants, Год журнала: 2024, Номер 13(3), С. 286 - 286
Опубликована: Фев. 26, 2024
With a widespread distribution throughout the Northern Hemisphere and 11 genera, Pinaceae is largest family of
Язык: Английский
Процитировано
19
European journal of medical research, Год журнала: 2024, Номер 29(1)
Опубликована: Янв. 30, 2024
Abstract Cancer is a disease that can cause abnormal cell growth and spread throughout the body. It among most significant causes of death worldwide, resulting in approx. 10 million deaths annually. Many synthetic anticancer drugs are available, but they often come with side effects interact negatively other medications. Additionally, many chemotherapy used for cancer treatment develop resistance harm normal cells, leading to dose-limiting effects. As result, finding effective treatments developing new remains challenge. However, plants potent source natural products potential treatment. These biologically active compounds may be basis enhanced or less toxic derivatives. Herbal medicines/phytomedicines, plant-based drugs, becoming more popular treating complicated diseases like due their effectiveness particularly attractive option affordability, availability, lack serious They have broad applicability therapeutic efficacy, which has spurred scientific research into as agents. This review focuses on Paclitaxel (PTX), drug derived from Taxus sp., its ability treat specific tumors. PTX derivatives against various lines. Researchers use this detailed information affordable cancer.
Язык: Английский
Процитировано
18
European journal of medical research, Год журнала: 2023, Номер 28(1)
Опубликована: Сен. 14, 2023
Abstract Cancer poses a significant global health challenge, with predictions of increasing prevalence in the coming years due to limited prevention, late diagnosis, and inadequate success current therapies. In addition, high cost new anti-cancer drugs creates barriers meeting medical needs cancer patients, especially developing countries. The lengthy costly process novel further hinders drug discovery clinical implementation. Therefore, there has been growing interest repurposing approved for other diseases address urgent need effective treatments. aim this comprehensive review is provide an overview potential non-oncology as therapeutic options treatment. These come from various chemotherapeutic classes, including antimalarials, antibiotics, antivirals, anti-inflammatory drugs, antifungals, have demonstrated antiproliferative, pro-apoptotic, immunomodulatory, antimetastatic properties. A systematic literature was conducted identify relevant studies on therapy. Various electronic databases, such PubMed, Scopus, Google Scholar, were searched using appropriate keywords. Studies focusing potential, mechanisms action, efficacy, prospects repurposed treatment included analysis. highlights promising outcomes Drugs belonging different classes notable antitumor effects, inhibiting cell proliferation, promoting apoptosis, modulating immune response, suppressing metastasis. findings suggest these approaches Repurposing provides strategy addressing accessible diverse their properties, offer avenues Further research trials are warranted explore full optimize use treating types. can significantly expedite identifying treatments improve patient cost-effective manner.
Язык: Английский
Процитировано
32
Phytotherapy Research, Год журнала: 2023, Номер 38(2), С. 592 - 619
Опубликована: Ноя. 6, 2023
Abstract Sterols, including β‐sitosterol, are essential components of cellular membranes in both plant and animal cells. Despite being a major phytosterol various materials, comprehensive scientific knowledge regarding the properties β‐sitosterol its potential applications is for scholarly pursuits utilization purposes. shares similar chemical characteristics with cholesterol exhibits several pharmacological activities without toxicity. This study aims to bridge gap between phytochemistry current evidence focusing on anticancer activity other biomedical properties. The goal provide understanding β‐sitosterol's future translational approaches. A thorough examination literature was conducted gather relevant information biological particularly therapeutic potential. Various databases were searched, PubMed/MedLine, Scopus, Google Scholar, Web Science using appropriate keywords. Studies investigating effects different types cancer analyzed, mechanisms action, screening, chemosensitizing Modern screening studies have revealed against cancer, leukemia, lung, stomach, breast, colon, ovarian, prostate cancer. has demonstrated cells, interfering multiple cell signaling pathways involved proliferation, cycle arrest, apoptosis, survival, metastasis invasion, angiogenesis, inflammation. Structural derivatives also shown anti‐cancer effects. However, research field drug delivery detailed mode action β‐sitosterol‐mediated remains limited. as non‐toxic compound significant potential, promising types. relatively less potent than conventional chemotherapeutics, holds safe effective nutraceutical Further recommended explore develop novel formulations use treatment. review provides foundation investigations highlights need further superfood combating
Язык: Английский
Процитировано
17
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Март 23, 2023
Alternariol is a toxic metabolite of Alternaria fungi and studies have shown multiple potential pharmacological effects. To outline the anticancer effects mechanisms alternariol its derivatives based on database reports, an updated search PubMed/MedLine, ScienceDirect, Web Science, Scopus databases was performed with relevant keywords for published articles. The found to suggest that this mycotoxin and/or in many preclinical test systems. Scientific reports indicate exhibit through several pathways, including cytotoxic, reactive oxygen species leading oxidative stress mitochondrial dysfunction-linked cytotoxic effect, anti-inflammatory, cell cycle arrest, apoptotic death, genotoxic mutagenic, anti-proliferative, autophagy, estrogenic clastogenic mechanisms. In light these results, may be one hopeful chemotherapeutic agents.
Язык: Английский
Процитировано
16
Chinese Medicine, Год журнала: 2023, Номер 18(1)
Опубликована: Март 2, 2023
Abstract Paeonia emodi Wall. ex Royle is commonly known as Himalayan paeony has great importance a food and medicine. The practice of very ancient it conventionally used for wide range illnesses in the folk system medicine because its beneficial phytochemical profile. main purpose current review was synthesis recent data on botany, ethnopharmacology, phytochemistry potential pharmacological mechanisms action Royle, thus offering new prospects development adjuvant natural therapies. Using scientific databases such PubMed/MedLine, Scopus, Web Science, ScienceDirect, Google Scholar, Springer, Wiley, comprehensive literature search performed Royle. For searching, we next MeSH terms: “Biological Product/isolation purification”, Products/pharmacology”, “Drug Discovery/methods”, “Ethnopharmacology, Medicine”, “Traditional/methods”, “Paeonia/chemistry”, “Plant Extracts/pharmacology”, “Phytochemicals/chemistry”, “Phytochemicals/pharmacology”, “Plants, Medicinal”. results most studies were analyzed important summarized tables figures. Phytochemical research led to isolation triterpenes, monoterpenes, phenolic acids, fatty organic compounds, steroids, free radicals some other classes primary metabolites. In addition, diverse activities like antibacterial, antifungal, anticoagulant, airway relaxant lipoxygenase beta-glucuronidase inhibiting activity, radical scavenging phytotoxic insecticidal have been reported Different bioactive compounds proven their therapeutic modern biomedical cure numerous gastrointestinal nervous disorders. future, further vitro vivo are required identify action, pharmacokinetics studies, pharmaceutical formulations target transport possible interaction with allopathic drugs. Also, regarding quality evaluation, toxicity safety humans needed.
Язык: Английский
Процитировано
13