Archives of Dermatological Research, Год журнала: 2024, Номер 316(4)
Опубликована: Март 15, 2024
Язык: Английский
Nano-Micro Letters, Год журнала: 2024, Номер 16(1)
Опубликована: Фев. 6, 2024
Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients the healthcare system. Conventional therapies, such as corticosteroids nonsteroidal anti-inflammatory drugs, are limited in efficacy associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise addressing these challenges. NZ-based possess unique therapeutic abilities by combining benefits of redox nanomaterials enzymatic activity water-retaining capacity hydrogels. The multifaceted effects include scavenging reactive oxygen species other inflammatory mediators modulating immune responses toward pro-regenerative environment enhancing regenerative potential triggering cell migration differentiation. This review highlights current state art NZ-engineered (NZ@hydrogels) for regeneration applications. It also discusses underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, challenges future directions this ground, particularly clinical translation, addressed. insights provided aid design engineering novel hydrogels, offering new possibilities targeted personalized skin-care therapies.
Язык: Английский
Процитировано
36
Antioxidants, Год журнала: 2023, Номер 12(1), С. 135 - 135
Опубликована: Янв. 6, 2023
Alopecia areata (AA) is a dermatological condition characterized by non-scarring hair loss. Exact etiopathogenesis of AA still unknown although it known that several factors contribute to the collapse hair-follicle (HF)-immune-privileged (IP) site. Oxidative stress (OS) plays an important role in skin diseases. The aim this review was clarify OS pathogenesis and diagnosis, discuss potential treatment options. Oxidative-stress markers are altered serum samples patients with AA, confirming general pro-oxidative status AA. induces MHC class I chain-related A (MICA) expression HF keratinocytes activates receptor NKG2D, expressed NK cells CD8+ T cytotoxic leading destabilization immune-privileged site through production IFN-γ stimulates JAK1 JAK2 pathways. also KEAP1-NRF2 pathway, antioxidant system contributes homeostasis. In addition, decrease ATG5 LC3B matrix increase p62 levels indicates reduction intrafollicular autophagy during evolution Potential biomarkers could be: malondialdehyde (MDA), advanced glycation end-products (AGEs), ischemic-modified albumin (IMA). JAK inhibitors new frontier use nutraceuticals modulate balance, combination standard treatments, represent promising therapeutic tools.
Язык: Английский
Процитировано
33
Gels, Год журнала: 2023, Номер 9(6), С. 451 - 451
Опубликована: Май 30, 2023
Polymeric materials have found increasing use in biomedical applications the last decades. Among them, hydrogels represent chosen class of to this field, particular as wound dressings. They are generally non-toxic, biocompatible, and biodegradable, they can absorb large amounts exudates. Moreover, actively contribute skin repair promoting fibroblast proliferation keratinocyte migration, allowing oxygen permeate, protecting wounds from microbial invasion. As dressing, stimuli-responsive systems particularly advantageous since be active only response specific environmental stimuli (such pH, light, ROS concentration, temperature, glucose level). In review, we briefly resume human skin’s structure functions, well healing phases; then, present recent advances hydrogels-based Lastly, provide a bibliometric analysis knowledge produced field.
Язык: Английский
Процитировано
26
Pharmaceutics, Год журнала: 2023, Номер 15(7), С. 1828 - 1828
Опубликована: Июнь 26, 2023
Carotenoids are natural products regulated by the food sector, currently used as feed dyes and antioxidants in dietary supplements composing functional foods for human consumption. Of nearly one thousand carotenoids described to date, only retinoids, derived from beta carotene, have status of a drug pharmaceutical sector. In this review, we address novel field: transformation xanthophylls, particularly highly marketed astaxanthin practically unknown bacterioruberin, therapeutic agents altering their pharmacokinetics, biodistribution, pharmacodynamics through formulation nanomedicines. The antioxidant activity xanthophylls is mediated routes different those classical oral anti-inflammatory drugs such corticosteroids non-steroidal (NSAIDs): remarkably, lack but also toxicity. Formulated nanomedicines, gain mechanisms other than increased bioavailability. Loaded into ad hoc tailored nanoparticles protect structure throughout storage during gastrointestinal transit or skin penetration, can be targeted delivered selected inflamed cell groups, achieving massive intracellular concentration after endocytosis small doses formulation. Most first reports showing activities topical xanthophyll-based nanomedicines against chronic diseases inflammatory bowel disease, psoriasis, atopic dermatitis, dry eye disease emerged between 2020 2023. Here discuss detail preclinical performance, mostly vesicular polymeric nanoparticles, on cellular models vivo. results, although preliminary, auspicious enough speculate upon potential use administration treatment diseases.
Язык: Английский
Процитировано
23
Communications Biology, Год журнала: 2024, Номер 7(1)
Опубликована: Ноя. 19, 2024
Abstract Wound healing is a highly coordinated spatiotemporal sequence of events involving several cell types and tissues. The process wound requires strict regulation, its disruption can lead to the formation chronic wounds, which have significant impact on an individual’s health as well worldwide healthcare expenditure. One essential aspect within cellular molecular regulation pathogenesis that reactive oxygen species (ROS) oxidative stress. Wounding significantly elevates levels ROS, array various are involved in modulating process, such through antimicrobial activities signal transduction. However, many pathologies, ROS play antagonistic pleiotropic role healing, be pathogenic factor wounds. Whilst advances targeting stress led development novel pre-clinical therapeutic methods, due complex nature gaps knowledge remain concerning specific functions healing. In this review, we highlight current these functions, discuss potential future direction new studies, how pathways may targeted studies.
Язык: Английский
Процитировано
11
Disease Models & Mechanisms, Год журнала: 2025, Номер 18(1)
Опубликована: Янв. 1, 2025
ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disease, characterized by an impaired epidermal barrier and immunological alterations. The activity of the cytoprotective NRF2 transcription factor reduced in epidermis AD patients. To determine functional relevance this deficiency, we used mice lacking fibroblast growth receptors 1 2 keratinocytes (K5-R1/R2 mice), which exhibit several AD-like symptoms. Proteomics analysis their revealed Nrf2 activity. This was accompanied increase DNA damage number senescent cells. Genetic deletion these further promoted senescence, but time-limited pharmacological activation had mild protective effect. Surprisingly, long-term genetic K5-R1/R2 caused strong hyperkeratosis, keratinocyte hyperproliferation, thickening, increased apoptosis damage, altered immune cell composition. These results reveal complex role show necessity to optimize duration intensity for treatment alterations patients with AD.
Язык: Английский
Процитировано
1
International Journal of Dermatology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 28, 2025
ABSTRACT This review provides an in‐depth analysis of the pathophysiology melasma and highlights recent studies that elucidate its underlying mechanisms. Given prevalence melasma, a thorough understanding pathogenesis is critical for development effective treatment strategies. We analyzed current literature to identify findings related epidermal changes, basement membrane (BM) alterations, various dermal modifications, including solar elastosis, mast cell activity, vascular changes. also examined influence visible light (VL) hormonal fluctuations on melasma. intertwines these insights with overview contemporary approaches. Our indicate advancements in melasma's pathophysiology, highlighting significant changes epidermis BM, along factors, such as involvement, senescent fibroblasts. established mechanisms while incorporating scientific updates. Additionally, survey available treatments targeting novel revealed promising therapeutic modalities currently under investigation. In conclusion, latest pathophysiological crucial enhancing clinician awareness patient reassurance, well improving Nevertheless, ongoing research remains essential complexities further optimize clinical outcomes.
Язык: Английский
Процитировано
1
Biomolecules, Год журнала: 2022, Номер 12(12), С. 1904 - 1904
Опубликована: Дек. 19, 2022
Atopic dermatitis is a chronic inflammatory skin disease in which the overproduction of reactive oxygen species plays pivotal role pathogenesis and persistence lesions. Phototherapy represents one most used therapeutic options, with benefits clinical picture. Studies have demonstrated immunomodulatory effect phototherapy its reducing molecule hallmarks oxidative stress. In this review, we report data present literature dealing main signaling molecular pathways involved stress after to target atopic dermatitis-affected cells. Since flare-up, new research lines could be opened study drugs that act on mechanism, perhaps concert phototherapy.
Язык: Английский
Процитировано
29
Molecules, Год журнала: 2022, Номер 27(19), С. 6694 - 6694
Опубликована: Окт. 8, 2022
The incidence of allergic diseases and their complications are increasing worldwide. Today, people increasingly use natural products, which has been termed a “return to nature”. Natural products with healing properties, especially those obtained from plants bees, have used in the prevention treatment numerous chronic diseases, including allergy and/or inflammation. Propolis is multi-component resin rich flavonoids, collected transformed by honeybees buds plant wounds for construction adaptation nests. This article describes current views regarding possible mechanisms multiple benefits flavonoids combating allergy-related complications. These arise flavonoid anti-allergic, anti-inflammatory, antioxidative, wound activities effects on microbe-immune system interactions developing host responses different allergens. Finally, this presents various aspects pathobiology molecular approaches treatment. Possible antiallergic action propolis microbiota digestive respiratory tracts skin as method selectively remove allergenic molecules process bacterial biotransformation also reported.
Язык: Английский
Процитировано
28
Molecules, Год журнала: 2023, Номер 28(3), С. 1192 - 1192
Опубликована: Янв. 25, 2023
Phytocannabinoids are naturally occurring compounds, the main source of which is Cannabis sativa L. Through direct action or interaction with G protein-coupled receptors, they affect ROS and pro-inflammatory cytokines levels modify effectiveness transcription factor responsible for biosynthesis antioxidants lead to oxidative stress its consequences. Due modification redox balance inflammation, phytocannabinoids used in treatment various diseases, including autoimmune dermatoses, such as atopic dermatitis psoriasis. Psoriasis one most common unknown etiology. A disturbed a shift towards oxidation leads stress, resulting modifications, mainly lipids proteins, prolonged activation immune cells increased generation cytokines, chronic inflammation. Given biological activity phytocannabinoids, have become focus research components pharmacotherapy Beneficial effects were shown by representatives but effect cannabidiol (CBD) on skin (in vitro ex vivo) blood from patients psoriasis vulgaris psoriatic arthritis has been often evaluated recent years.
Язык: Английский
Процитировано
19