Chinese Journal of Natural Medicines, Год журнала: 2024, Номер 22(3), С. 195 - 211
Опубликована: Март 1, 2024
Язык: Английский
Процитировано
94Dual targeting of FR+CD44 overexpressing tumors by self-assembled nanoparticles quantitatively conjugating folic acid-hyaluronic acid to the GSH-sensitively modified podophyllotoxin
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159276 - 159276
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
3Camellia sinensis: Insights on its molecular mechanisms of action towards nutraceutical, anticancer potential and other therapeutic applications
Arabian Journal of Chemistry, Год журнала: 2023, Номер 16(5), С. 104680 - 104680
Опубликована: Фев. 15, 2023
The Camellia sinensis plant provides a wide diversity of black, green, oolong, yellow, brick dark, and white tea. Tea is one the majorly used beverages across globe, succeeds only in water for fitness pleasure. Generally, green tea has been preferred more as compared to other teas due its main constituent e.g. polyphenols which contribute various health benefits. aim this updated comprehensive review bring together latest data on phytochemistry pharmacological properties highlight therapeutic prospects bioactive compounds so that full medicinal potential can be realised. A published studies topic was performed by searching PubMed/MedLine, Scopus, Google scholar, Web Science databases from 1999 2022. results analysed showed are four prime flavonoids catechins: epigallocatechin gallate (EGCG), epicatechin (ECG), (EGC), (EC) along with beneficial biological broad heterogeneity disorders, including anticancer, neuroprotective, antibacterial, antiviral, antifungal, antiobesity, antidiabetes antiglaucoma activities. Poor absorption low bioavailability limiting aspects their use. More human clinical approaching nanoformulation techniques nanoparticles transport target phytochemical increase efficacy needed future.
Язык: Английский
Процитировано
33Phytates as a natural source for health promotion: A critical evaluation of clinical trials
Frontiers in Chemistry, Год журнала: 2023, Номер 11
Опубликована: Апрель 14, 2023
Phytates are a type of organophosphorus compound produced in terrestrial ecosystems by plants. In plant feeds, phytic acid and its salt form, phytate, account for 60%–80% total phosphorus. Because phytate is polyanionic molecule, it can chelate positively charged cations such as calcium, iron, zinc. Due to prevalence vegetal tissues the fact that people consume plants, was first considered potential health benefit. This updated review aims summarize current data on results clinical trials phytates human health, highlighting both beneficial undesirable effects. To obtain these data, published papers electronic databases PubMed/MedLine, TRIP database, Wiley, Google Scholar, Baidu, Scopus were searched. Study have shown effects antioxidant, anticancer reduction pathological calcifications blood vessels organs; but also, negative reducing absorption minerals important maintaining homeostasis body. According recent derived from studies, may be natural source benefits. improve efficacy benefits, further dose-response studies needed determine effective therapeutic doses interactions with conventional drugs.
Язык: Английский
Процитировано
30Hyaluronic acid-based prodrug nanomedicines for enhanced tumor targeting and therapy: A review
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 249, С. 125993 - 125993
Опубликована: Июль 27, 2023
Язык: Английский
Процитировано
30Green Extraction of Plant Materials Using Supercritical CO2: Insights into Methods, Analysis, and Bioactivity
Plants, Год журнала: 2024, Номер 13(16), С. 2295 - 2295
Опубликована: Авг. 18, 2024
In recent years, the supercritical CO
Язык: Английский
Процитировано
11The Emerging Role of Natural Products in Cancer Treatment
Archives of Toxicology, Год журнала: 2024, Номер 98(8), С. 2353 - 2391
Опубликована: Май 25, 2024
Язык: Английский
Процитировано
10Multifunctional 5-hydroxyconiferaldehyde O-methyltransferases (CAldOMTs) in plant metabolism
Journal of Experimental Botany, Год журнала: 2024, Номер 75(6), С. 1671 - 1695
Опубликована: Янв. 10, 2024
Abstract Lignin, flavonoids, melatonin, and stilbenes are plant specialized metabolites with diverse physiological biological functions, supporting growth conferring stress resistance. Their biosynthesis requires O-methylations catalyzed by 5-hydroxyconiferaldehyde O-methyltransferase (CAldOMT; also called caffeic acid O-methyltransferase, COMT). CAldOMT was first known for its roles in syringyl (S) lignin angiosperm cell walls later found to be multifunctional. This enzyme catalyzes flavonoid, stilbene biosynthetic pathways. Phylogenetic analysis indicated the convergent evolution of enzymes OMT activities towards monolignol pathway intermediates some gymnosperm species that lack S-lignin Selaginella moellendorffii, a lycophyte which produces S-lignin. Furthermore, neofunctionalization CAldOMTs occurred repeatedly during evolution, generating unique O-methyltransferases (OMTs) novel catalytic and/or accepting substrates, including lignans, 1,2,3-trihydroxybenzene, phenylpropenes. review summarizes multiple aspects their related proteins metabolism discusses molecular mechanism, biorefineries, agriculture, synthetic biology.
Язык: Английский
Процитировано
7Recent advancements in natural compounds for cancer therapy and prevention
Phytochemistry Reviews, Год журнала: 2024, Номер unknown
Опубликована: Март 28, 2024
Язык: Английский
Процитировано
7Investigating the proliferative inhibition of HepG2 cells by exosome-like nanovesicles derived from Centella asiatica extract through metabolomics
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116855 - 116855
Опубликована: Июнь 7, 2024
Nano-particles demonstrating excellent anticancer properties have gradually found application in cancer therapy. However, their widespread use is impeded by potential toxicity, high cost, and the complexity of preparation process. In this study, we achieved exosome-like Centella asiatica-derived nanovesicles (ADNVs) through a straightforward juicing high-speed centrifugation We employed transmission electron microscopy nanoparticle flow cytometry to characterize morphology, diameter, stability ADNVs. evaluated vitro effects ADNVs using Cell Counting Kit-8 apoptosis assays. Through sequencing bicinchoninic acid protein analysis, discovered abundant presence proteins microRNAs These can target various diseases such as infection. Furthermore, demonstrated effective internalization HepG2 cells, resulting an increase reactive oxygen species levels, mitochondrial damage, cell cycle arrest at G1 phase, apoptosis. Finally, analyzed changes cellular metabolites post-treatment metabolomics techniques. Our findings indicated that primarily influence metabolic pathways amino metabolism lipid biosynthesis, which are closely associated with treatment. results demonstrate utility agents.
Язык: Английский
Процитировано
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