Chinese Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: 22(3), P. 195 - 211
Published: March 1, 2024
Language: Английский
Citations
94Dual targeting of FR+CD44 overexpressing tumors by self-assembled nanoparticles quantitatively conjugating folic acid-hyaluronic acid to the GSH-sensitively modified podophyllotoxin
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159276 - 159276
Published: Jan. 1, 2025
Language: Английский
Citations
3Camellia sinensis: Insights on its molecular mechanisms of action towards nutraceutical, anticancer potential and other therapeutic applications
Arabian Journal of Chemistry, Journal Year: 2023, Volume and Issue: 16(5), P. 104680 - 104680
Published: Feb. 15, 2023
The Camellia sinensis plant provides a wide diversity of black, green, oolong, yellow, brick dark, and white tea. Tea is one the majorly used beverages across globe, succeeds only in water for fitness pleasure. Generally, green tea has been preferred more as compared to other teas due its main constituent e.g. polyphenols which contribute various health benefits. aim this updated comprehensive review bring together latest data on phytochemistry pharmacological properties highlight therapeutic prospects bioactive compounds so that full medicinal potential can be realised. A published studies topic was performed by searching PubMed/MedLine, Scopus, Google scholar, Web Science databases from 1999 2022. results analysed showed are four prime flavonoids catechins: epigallocatechin gallate (EGCG), epicatechin (ECG), (EGC), (EC) along with beneficial biological broad heterogeneity disorders, including anticancer, neuroprotective, antibacterial, antiviral, antifungal, antiobesity, antidiabetes antiglaucoma activities. Poor absorption low bioavailability limiting aspects their use. More human clinical approaching nanoformulation techniques nanoparticles transport target phytochemical increase efficacy needed future.
Language: Английский
Citations
33Phytates as a natural source for health promotion: A critical evaluation of clinical trials
Frontiers in Chemistry, Journal Year: 2023, Volume and Issue: 11
Published: April 14, 2023
Phytates are a type of organophosphorus compound produced in terrestrial ecosystems by plants. In plant feeds, phytic acid and its salt form, phytate, account for 60%–80% total phosphorus. Because phytate is polyanionic molecule, it can chelate positively charged cations such as calcium, iron, zinc. Due to prevalence vegetal tissues the fact that people consume plants, was first considered potential health benefit. This updated review aims summarize current data on results clinical trials phytates human health, highlighting both beneficial undesirable effects. To obtain these data, published papers electronic databases PubMed/MedLine, TRIP database, Wiley, Google Scholar, Baidu, Scopus were searched. Study have shown effects antioxidant, anticancer reduction pathological calcifications blood vessels organs; but also, negative reducing absorption minerals important maintaining homeostasis body. According recent derived from studies, may be natural source benefits. improve efficacy benefits, further dose-response studies needed determine effective therapeutic doses interactions with conventional drugs.
Language: Английский
Citations
30Hyaluronic acid-based prodrug nanomedicines for enhanced tumor targeting and therapy: A review
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 249, P. 125993 - 125993
Published: July 27, 2023
Language: Английский
Citations
30Green Extraction of Plant Materials Using Supercritical CO2: Insights into Methods, Analysis, and Bioactivity
Plants, Journal Year: 2024, Volume and Issue: 13(16), P. 2295 - 2295
Published: Aug. 18, 2024
In recent years, the supercritical CO
Language: Английский
Citations
11The Emerging Role of Natural Products in Cancer Treatment
Archives of Toxicology, Journal Year: 2024, Volume and Issue: 98(8), P. 2353 - 2391
Published: May 25, 2024
Language: Английский
Citations
10Multifunctional 5-hydroxyconiferaldehyde O-methyltransferases (CAldOMTs) in plant metabolism
Journal of Experimental Botany, Journal Year: 2024, Volume and Issue: 75(6), P. 1671 - 1695
Published: Jan. 10, 2024
Abstract Lignin, flavonoids, melatonin, and stilbenes are plant specialized metabolites with diverse physiological biological functions, supporting growth conferring stress resistance. Their biosynthesis requires O-methylations catalyzed by 5-hydroxyconiferaldehyde O-methyltransferase (CAldOMT; also called caffeic acid O-methyltransferase, COMT). CAldOMT was first known for its roles in syringyl (S) lignin angiosperm cell walls later found to be multifunctional. This enzyme catalyzes flavonoid, stilbene biosynthetic pathways. Phylogenetic analysis indicated the convergent evolution of enzymes OMT activities towards monolignol pathway intermediates some gymnosperm species that lack S-lignin Selaginella moellendorffii, a lycophyte which produces S-lignin. Furthermore, neofunctionalization CAldOMTs occurred repeatedly during evolution, generating unique O-methyltransferases (OMTs) novel catalytic and/or accepting substrates, including lignans, 1,2,3-trihydroxybenzene, phenylpropenes. review summarizes multiple aspects their related proteins metabolism discusses molecular mechanism, biorefineries, agriculture, synthetic biology.
Language: Английский
Citations
7Recent advancements in natural compounds for cancer therapy and prevention
Phytochemistry Reviews, Journal Year: 2024, Volume and Issue: unknown
Published: March 28, 2024
Language: Английский
Citations
7Investigating the proliferative inhibition of HepG2 cells by exosome-like nanovesicles derived from Centella asiatica extract through metabolomics
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116855 - 116855
Published: June 7, 2024
Nano-particles demonstrating excellent anticancer properties have gradually found application in cancer therapy. However, their widespread use is impeded by potential toxicity, high cost, and the complexity of preparation process. In this study, we achieved exosome-like Centella asiatica-derived nanovesicles (ADNVs) through a straightforward juicing high-speed centrifugation We employed transmission electron microscopy nanoparticle flow cytometry to characterize morphology, diameter, stability ADNVs. evaluated vitro effects ADNVs using Cell Counting Kit-8 apoptosis assays. Through sequencing bicinchoninic acid protein analysis, discovered abundant presence proteins microRNAs These can target various diseases such as infection. Furthermore, demonstrated effective internalization HepG2 cells, resulting an increase reactive oxygen species levels, mitochondrial damage, cell cycle arrest at G1 phase, apoptosis. Finally, analyzed changes cellular metabolites post-treatment metabolomics techniques. Our findings indicated that primarily influence metabolic pathways amino metabolism lipid biosynthesis, which are closely associated with treatment. results demonstrate utility agents.
Language: Английский
Citations
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