Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Март 9, 2023
Cancer is a severe health issue, and cancer cases are rising yearly. New anticancer drugs have been developed as our understanding of the molecular mechanisms behind diverse solid tumors, metastatic malignancies increased. Plant-derived phytochemical compounds target different oncogenes, tumor suppressor genes, protein channels, immune cells, pumps, which attracted much attention for treating in preclinical studies. Despite capabilities these compounds, systemic toxicity, medication resistance, limited absorption remain more significant obstacles clinical trials. Therefore, drug combinations new phytonanomedicine, semi-synthetic, synthetic analogs should be considered to supplement existing therapies. It also crucial consider strategies increased production bioactive substances. The primary goal this review highlight several found plants, research, their semi-synthetic analogs, Additionally, biotechnological metabolic engineering explored enhance compounds. Ligands interactions with putative targets through docking emphasis given gathering comprehensive data regarding modern biotechnology, engineering, biology, silico tools.
Язык: Английский
Процитировано
16An updated overview of anticancer effects of alternariol and its derivatives: underlying molecular mechanisms
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Март 23, 2023
Alternariol is a toxic metabolite of Alternaria fungi and studies have shown multiple potential pharmacological effects. To outline the anticancer effects mechanisms alternariol its derivatives based on database reports, an updated search PubMed/MedLine, ScienceDirect, Web Science, Scopus databases was performed with relevant keywords for published articles. The found to suggest that this mycotoxin and/or in many preclinical test systems. Scientific reports indicate exhibit through several pathways, including cytotoxic, reactive oxygen species leading oxidative stress mitochondrial dysfunction-linked cytotoxic effect, anti-inflammatory, cell cycle arrest, apoptotic death, genotoxic mutagenic, anti-proliferative, autophagy, estrogenic clastogenic mechanisms. In light these results, may be one hopeful chemotherapeutic agents.
Язык: Английский
Процитировано
16A comprehensive review on traditional uses, phytochemistry and pharmacological properties of Paeonia emodi Wall. ex Royle: current landscape and future perspectives
Chinese Medicine, Год журнала: 2023, Номер 18(1)
Опубликована: Март 2, 2023
Abstract Paeonia emodi Wall. ex Royle is commonly known as Himalayan paeony has great importance a food and medicine. The practice of very ancient it conventionally used for wide range illnesses in the folk system medicine because its beneficial phytochemical profile. main purpose current review was synthesis recent data on botany, ethnopharmacology, phytochemistry potential pharmacological mechanisms action Royle, thus offering new prospects development adjuvant natural therapies. Using scientific databases such PubMed/MedLine, Scopus, Web Science, ScienceDirect, Google Scholar, Springer, Wiley, comprehensive literature search performed Royle. For searching, we next MeSH terms: “Biological Product/isolation purification”, Products/pharmacology”, “Drug Discovery/methods”, “Ethnopharmacology, Medicine”, “Traditional/methods”, “Paeonia/chemistry”, “Plant Extracts/pharmacology”, “Phytochemicals/chemistry”, “Phytochemicals/pharmacology”, “Plants, Medicinal”. results most studies were analyzed important summarized tables figures. Phytochemical research led to isolation triterpenes, monoterpenes, phenolic acids, fatty organic compounds, steroids, free radicals some other classes primary metabolites. In addition, diverse activities like antibacterial, antifungal, anticoagulant, airway relaxant lipoxygenase beta-glucuronidase inhibiting activity, radical scavenging phytotoxic insecticidal have been reported Different bioactive compounds proven their therapeutic modern biomedical cure numerous gastrointestinal nervous disorders. future, further vitro vivo are required identify action, pharmacokinetics studies, pharmaceutical formulations target transport possible interaction with allopathic drugs. Also, regarding quality evaluation, toxicity safety humans needed.
Язык: Английский
Процитировано
13Key oncologic pathways inhibited by Erinacine A: A perspective for its development as an anticancer molecule
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 160, С. 114332 - 114332
Опубликована: Фев. 1, 2023
In the modern era, cancer can be controlled by chemotherapy treatment, and in many situations a stable disease is obtained. The significant clinical success subsequent commercialization of naturally derived molecules have further encouraged their exploration as adjunctive therapies management. purpose this comprehensive review to update anticancer mechanisms triggered Erinacine A regulation signaling pathways potentially involved its activity.The results preclinical research showed that Erinacin A, therapeutically important biological metabolite isolated from basidiomycete fungus Hericium erinaceus offers multitude possible chemotherapeutic applications regulating complex validated various pharmacological vitro vivo studies. As result A's action on oncological pathways, it resulted induction apoptosis, reduction proliferation, invasiveness, generation oxidative stress cell cycle arrest cells.
Язык: Английский
Процитировано
12Ethnopharmacologically important highly subsidized Indian medicinal plants: Systematic review on their traditional uses, phytochemistry, pharmacology, quality control, conservation status and future prospective
Journal of Ethnopharmacology, Год журнала: 2023, Номер 320, С. 117385 - 117385
Опубликована: Ноя. 10, 2023
Язык: Английский
Процитировано
11Advances in nanoscale carrier-based approaches to reduce toxicity and enhance efficacy of podophyllotoxin
Acta Materia Medica, Год журнала: 2023, Номер 2(4)
Опубликована: Янв. 1, 2023
Podophyllotoxin (PPT), an aryltetralin-type lignan isolated from Podophyllum species, exhibits a wide range of biologic and pharmacologic activities, mainly serves as antiviral agent or antitumor drug in clinical applications. However, the therapeutic potential PPT has been hindered due to its detrimental systemic toxicity, poor solubility, bioavailability. Nanoparticles, which preferentially accumulate tumors through enhanced permeability retention effects, have become useful tools for targeted delivery, thus securing niche cancer therapies. The nano-based delivery platform introduced purpose improved efficacy, reduced toxicity. For decades, extensive efforts dedicated designing developing various systems mitigate undesirable toxicity expand applicability. Herein, we briefly review latest achievements patterns pharmacodynamic concerns with expectation shedding light on future research applications PPT.
Язык: Английский
Процитировано
11Noncanonical inhibition of topoisomerase II alpha by oxidative stress metabolites
Redox Biology, Год журнала: 2025, Номер unknown, С. 103504 - 103504
Опубликована: Янв. 1, 2025
During its catalytic cycle, the homodimeric ATPase topoisomerase II alpha (TOP2A) cleaves double stranded DNA and remains covalently bound to 5' ends via tyrosine phosphodiester bonds. After passing a second, intact duplex through, TOP2A rejoins break releases from DNA. Thereby, can relieve strain accumulated during transcription, replication chromatin remodeling disentangle sister chromatids for mitosis. Chemotherapy agents such as etoposide are poisons that trap mid-cycle, cleaved DNA, leaving behind strand breaks activating damage response. While has been proposed stabilize TOP2A-DNA cleavage complex (TOP2Acc) interfacial inhibition, we have elucidated complementary mechanism mediated by ability of other induce oxidative stress. Consequently, lipid peroxidation accumulation lipid-derived electrophiles 4-hydroxynonenal (HNE) results in covalent modification TOP2A, both blocking activity trapping TOP2Acc. HNE modifies multiple sites on human vitro, including alkylating Cys216 domain DNA-dependent fashion. Taken together, our data suggest an underappreciated role redox sensor tumor cells, connecting stress signaling thereby creating target redox-active drugs.
Язык: Английский
Процитировано
0Bioconjugation of Podophyllotoxin and Nanosystems: Approaches for Boosting Its Biopharmaceutical and Antitumoral Profile
Pharmaceuticals, Год журнала: 2025, Номер 18(2), С. 169 - 169
Опубликована: Янв. 26, 2025
Podophyllotoxin is a natural compound belonging to the lignan family and well-known for its great antitumor activity. However, it shows several limitations, such as severe side effects some pharmacokinetics problems, including low water solubility, which hinders application an anticancer agent. Over past few years, research has been focused on developing nanotechnology-based medicines or nanomedicines allow researchers improve pharmacokinetic properties of compounds. Following this trend, podophyllotoxin nanoconjugates have obtained overcome biopharmaceutical drawbacks enhance properties. The objective review highlight advances made over years (2017–2023) regarding inclusion in different nanosystems. Among huge variety diverse nature, drug delivery systems bearing cytotoxic payload are organic nanoparticles mainly based polymer carriers, micelles, liposomes. Along with description their pharmacological antitumorals advantages compared free terms biocompatibility, selectivity, we also provide insight into synthetic procedures developed obtain those podophyllotoxin-nanocarriers. Typical regard self-assembly techniques, nanoprecipitations, ionic gelation methods among others. This comprehensive perspective aims enlighten medicinal chemistry community about tendencies followed design new podophyllotoxin-based systems, features applications.
Язык: Английский
Процитировано
0Cloning and bioinformatics analysis of key gene ShOMT3 of podophyllotoxin biosynthesis pathway in Sinopodophyllum hexandrum
PLoS ONE, Год журнала: 2025, Номер 20(2), С. e0314919 - e0314919
Опубликована: Фев. 14, 2025
Sinopodophyllum hexandrum ( S. ) is an endangered traditional Chinese medicine as abundant podophyllotoxin with powerful anticancer activity. In this study, the rootstalks of from different geographical locations in China [S1 (Gansu) and S2 (Shaanxi)] were used research materials to clone key gene pluviatolide O-methyltransferase 3 ShOMT3 biosynthetic pathway. Subsequently, bioinformatics analysis its encoded protein was subjected using various software including ProtParam, DeepTMHMM, SubLoc, Signal-P 5.0, Swiss-model. The results revealed that CDS region 1119 bp long, encoding 372 amino acids. theoretical molecular weight 41.32784 kD, isoelectric point (pI) 5.27. instability coefficient 46.05, aliphatic index 93.58, grand average hydropathicity (GRAVY) 0.037, indicating it unstable hydrophobic protein. does not contain transmembrane domains or signal peptides, a non-secreted Secondary structure prediction suggests consists alpha helices, random coils, extended strands, beta-turns. Tertiary functions monomer. phylogenetic tree, has highest homology Podophyllum peltatum P. ). successful cloning provide basis excellent genetic resources for regulatory mechanism pathway breeding .
Язык: Английский
Процитировано
0Endophytic fungi in Himalayan medicinal plants: isolation procedures, diversity, and therapeutic applications
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 27 - 54
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
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