Molecules, Год журнала: 2023, Номер 28(16), С. 6141 - 6141
Опубликована: Авг. 19, 2023
Fruits and vegetables are used not only for nutritional purposes but also as therapeutics to treat various diseases ailments. These food items prominent sources of phytochemicals that exhibit chemopreventive therapeutic effects against several diseases. Hirsutine (HSN) is a naturally occurring indole alkaloid found in Uncaria species has multitude benefits. It foodstuffs such fish, seafood, meat, poultry, dairy, some grain products among other things. In addition, it present fruits including corn, cauliflower, mushrooms, potatoes, bamboo shoots, bananas, cantaloupe, citrus fruits. The primary emphasis this study summarize the pharmacological activities underlying mechanisms HSN different diseases, well biopharmaceutical features. For this, data were collected (up date 1 July 2023) from reliable authentic literature by searching academic search engines, PubMed, Springer Link, Scopus, Wiley Online, Web Science, ScienceDirect, Google Scholar. Findings indicated exerts preclinical experimental systems. exhibits anti-inflammatory, antiviral, anti-diabetic, antioxidant with beneficial neurological cardiovascular Our findings indicate promising anticancer potentials via molecular mechanisms, apoptotic cell death, induction oxidative stress, cytotoxic effect, anti-proliferative genotoxic inhibition cancer migration invasion cancers lung, breast, antitumor human T-cell leukemia. Taken all together, show can be agent cancer.
Язык: Английский
Процитировано
32
Chemistry & Biodiversity, Год журнала: 2023, Номер 21(2)
Опубликована: Дек. 27, 2023
Abstract Rotundic acid (RA) is a naturally occurring pentacyclic triterpene with multitude of pharmacological activities. The primary emphasis this study on summarizing the anticancer properties underlying mechanisms RA and its derivatives, as well pharmacokinetic features. Data was collected (up to date November 10, 2023) from various reliable authentic literatures by searching in different academic search engines, including PubMed, Springer Link, Scopus, Wiley Online, Web Science, ScienceDirect, Google Scholar. findings imply that synthetic derivatives possess promising anti‐cancer against breast, colorectal, liver, cervical cancers preclinical test systems. results also indicate demonstrated effects via number cellular mechanisms, apoptotic cell death, inhibition oxidative stress, anti‐inflammatory effect, cytotoxicity, cycle arrest, anti‐proliferative anti‐angiogenic cancer migration invasion. It has been proposed derived compounds have capability serve hopeful chemotherapeutic agent, so further extensive clinical research necessary.
Язык: Английский
Процитировано
17
Archives of Toxicology, Год журнала: 2024, Номер 98(6), С. 1659 - 1683
Опубликована: Апрель 25, 2024
Abstract Alternaria species are mycotoxin-producing fungi known to infect fresh produce and cause their spoilage. Humans get exposed fungal secondary metabolites as mycotoxin via the ingestion of contaminated food. Alternariol (AOH) (C 14 H 10 O 5 ) is an isocoumarins produced by different including alternata . AOH often found in grain, fruits fruits-based food products with high levels legumes, nuts, tomatoes. was first discovered 1953, it nowadays linked esophagus cancer endocrine disruption due its similarity estrogen. Although considered emerging no regulated food, occurs highly consumed dietary has been detected various masked forms, which adds occurrence. Therefore, this comprehensive review developed give overview on recent literature field AOH. The current study summarizes published data occurrence last ten years evaluates those comparison recommended regulating entities. Such surveillance facilitates work health risk assessors highlights commodities that most need regulation. In addition, effects cells animal models were summarized two tables; include two-year studies. addresses also main characteristics possible human exposure routes, populations at risk, effect anthropogenic activities widespread mycotoxin. commonly used detection control methods described latest discussed guide future researchers focus mitigating mycotoxins contamination industry. This aims mainly serve a guideline for regulation developers assessors.
Язык: Английский
Процитировано
5
Molecules, Год журнала: 2024, Номер 29(3), С. 579 - 579
Опубликована: Янв. 24, 2024
Consumers in developed and Western European countries are becoming more aware of the impact food on their health, they demand clear, transparent, reliable information from industry about products consume. They recognise that safety risks often due to unexpected presence contaminants throughout supply chain. Among these, mycotoxins produced by food-infecting fungi, endogenous toxins certain plants organisms, pesticides, other drugs used excessively during farming production, which lead contamination accumulation foodstuffs, main causes concern. In this context, goals review provide a comprehensive overview toxic molecules reported foodstuffs since 2020 through Rapid Alert System for Food Feed (RASFF) portal use chromatography address challenge. Overall, natural toxins, environmental pollutants, food-processing most frequently molecules, liquid gas approaches control. However, faster, simpler, powerful analytical procedures necessary cope with growing pressures chain supply.
Язык: Английский
Процитировано
4
Food & medicine homology., Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Applied and Environmental Microbiology, Год журнала: 2024, Номер 90(4)
Опубликована: Апрель 17, 2024
ABSTRACT Alternaria alternata FB1 is a marine fungus identified as candidate for plastic degradation in our previous study. This has been recently shown to produce secondary metabolites with significant antimicrobial activity against various pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and the notorious aquaculture pathogen Vibrio anguillarum . The antibacterial compounds were purified alternariol (AOH) its derivative, monomethyl ether (AME). We found that AOH AME primarily inhibited pathogenic bacteria (MRSA or V. ) by disordering cell division some other key physiological biochemical processes. further demonstrated could effectively inhibit unwinding of MRSA topoisomerases, which are closely related potential action target AOH. activities verified using zebrafish vivo model. Notably, did not significantly affect viability normal human liver cells at concentrations Finally, we developed genetic operation system A. blocked biosynthesis knocking out omtI (encoding an O-methyl transferase), facilitated only development this will accelerate discovery novel natural products bioactivity IMPORTANCE More more scientific reports indicate derivative (AME) exhibit activities. However, limited exploration their detailed mechanisms performed. In present study, produced disclosed vitro Given low toxicity on line under exhibiting different proposed be good candidates developing promising antibiotics also succeeded blocking AME, us easily obtain pure Moreover, based results, was enable polyethylene degradation.
Язык: Английский
Процитировано
2
Toxins, Год журнала: 2024, Номер 16(5), С. 223 - 223
Опубликована: Май 11, 2024
Alternariol monomethyl-ether (AME), together with altenuene and alternariol, belongs to the
Язык: Английский
Процитировано
1
Journal of Fungi, Год журнала: 2024, Номер 10(5), С. 352 - 352
Опубликована: Май 15, 2024
Talaromyces sp. DC2 is an endophytic fungus that was isolated from the stem of Catharanthus roseus (L.) G. Don in Hanoi, Vietnam and capable producing vinca alkaloids. This study utilizes PacBio Sequel technology to completely sequence whole genome DC2The revealed contains a total 34.58 Mb spanned by 156 contigs, with GC content 46.5%. The identification prediction functional protein-coding genes, tRNA, rRNA were comprehensively predicted highly annotated using various BLAST databases, including non-redundant (Nr) protein sequence, Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG), Clusters Orthologous Groups (COG), Carbohydrate-Active Enzymes (CAZy) databases. has 149, 227, 65, 153, 53, 6 genes responsible for cellulose, hemicellulose, lignin, pectin, chitin, starch, inulin degradation, respectively. Antibiotics Secondary Metabolites Analysis Shell (AntiSMASH) analyses strain possesses 20 biosynthetic gene clusters secondary metabolites. also been found harbor DDC encoding aromatic L-amino acid decarboxylase enzyme. Conclusively, this provided comprehensive understanding processes involved metabolites ability degrade plant cell walls.
Язык: Английский
Процитировано
1
LWT, Год журнала: 2024, Номер 203, С. 116353 - 116353
Опубликована: Июнь 18, 2024
Alternariol (AOH) is a metabolic product of Alternaria, which has various toxic effects on humans and animals its pollution increasingly being discovered in fruits, vegetables, grains. At present, the detection AOH mainly achieved through high-performance liquid chromatography-mass spectrometry immunological methods. However, there currently lack fast methods for on-site use. Considering unique advantages testing methods, this study developed an immunolateral chromatographic quantitative method detecting using quantum dot fluorescent nanospheres (QDFNs) as signal amplification materials. The range 5.2–4798 μg/kg, 50 % inhibiting concentration (IC50) 156.4 limit (LOD) value 2.32 quantification (LOQ) 6.96 μg/kg. recovery rates tomato strawberry were 95.27%–111.63% 88.43%–96.22%, respectively. In brief, approach good accuracy repeatability can be used AOH.
Язык: Английский
Процитировано
1
Food Control, Год журнала: 2024, Номер 165, С. 110682 - 110682
Опубликована: Июнь 28, 2024
This study aims to explore the presence of mycotoxins in total mixed rations (TMR) employed for feeding dairy cattle and their potential carry-over milk. A 87 TRM samples were collected farms from north Portugal 2019 2022. method based on a QuEChERS extraction followed by UHPLC-MS/MS detection was sample analysis. The in-house validated terms matrix effect, linearity, sensitivity, accuracy precision. most frequently detected regulated toxins fumonisins, with positivity rate 74%, while deoxynivalenol zearalenone found approximately 35% samples. Among emerging toxins, beauvericin enniatins exhibited highest rates. In addition, milk 21 farms, providing insights into these roquefortine milk, an estimated ranging between 2% 10%.
Язык: Английский
Процитировано
1