Materials Today Communications, Год журнала: 2023, Номер 38, С. 107951 - 107951
Опубликована: Дек. 23, 2023
Язык: Английский
Frontiers in Immunology, Год журнала: 2024, Номер 14
Опубликована: Янв. 15, 2024
Ferroptosis is an iron-dependent, novel form of programmed cell death characterized by lipid peroxidation and glutathione depletion widespread in a variety diseases. CD8+ T cells are the most important effector cytotoxic cells, capable specifically recognizing killing cancer cells. Traditionally, thought to induce mainly through perforin granzyme, Fas-L/Fas binding. In recent years, cell-derived IFN-γ was found promote ferroptosis multiple mechanisms, including upregulation IRF1 IRF8, downregulation system XC-, while shown enhance anti-tumor effects heating tumor immune microenvironment exposure release tumor-associated specific antigens, which results positive feedback pathway. Unfortunately, intra-tumoral more sensitive than limits application inducers cancer. addition, susceptible being regulated other TME, such as macrophages, dendritic Treg, bone marrow-derived immunosuppressive Together, these factors build complex network Therefore, we aim integrate relevant studies reveal potential mechanisms crosstalk between ferroptosis, summarize preclinical models therapy find new therapeutic strategies this review.
Язык: Английский
Процитировано
23
Cancer Communications, Год журнала: 2023, Номер 43(10), С. 1071 - 1096
Опубликована: Сен. 17, 2023
The advent of immunotherapy has significantly reshaped the landscape cancer treatment, greatly enhancing therapeutic outcomes for multiple types cancer. However, only a small subset individuals respond to it, underscoring urgent need new methods improve its response rate. Ferroptosis, recently discovered form programmed cell death, emerged as promising approach anti-tumor therapy, with targeting ferroptosis kill tumors seen potentially effective strategy. Numerous studies suggest that inducing can synergistically enhance effects immunotherapy, paving way combined treatment method in future. Nevertheless, recent research raised concerns about potential negative impacts on immunity consequence ferroptosis, leading conflicting views within scientific community interplay between and immunity, thereby necessity comprehensive review existing literature this relationship. Previous reviews have touched related content, many focusing primarily promoting role while overlooking evidence inhibitory immunity. Others concentrated solely discussing content either from perspective cells or immune ferroptosis. Given both exist tumor microenvironment, one-sided discussion cannot comprehensively summarize topic. Therefore, perspectives tumor-infiltrating cells, we systematically current intending provide explanations identify work needed establish translational basis ferroptosis-targeted therapy treating tumors.
Язык: Английский
Процитировано
37
The Journal of Nutritional Biochemistry, Год журнала: 2024, Номер 130, С. 109647 - 109647
Опубликована: Апрель 10, 2024
Язык: Английский
Процитировано
6
Journal of Controlled Release, Год журнала: 2024, Номер 376, С. 659 - 677
Опубликована: Окт. 28, 2024
Язык: Английский
Процитировано
6
Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)
Опубликована: Июнь 29, 2023
Dihydroartemisinin (DHA), a natural product derived from the herbal medicine Artemisia annua, is recently used as novel anti-cancer agent. However, some intrinsic disadvantages limit its potential for clinical management of cancer patients, such poor water solubility and low bioavailability. Nowadays, nanoscale drug delivery system emerges hopeful platform improve treatment. Accordingly, metal-organic framework (MOF) based on zeolitic imidazolate framework-8 was designed synthesized to carry DHA in core (ZIF-DHA). Contrast with free DHA, these prepared ZIF-DHA nanoparticles (NPs) displayed preferable anti-tumor therapeutic activity several ovarian cells accompanied suppressed production cellular reactive oxygen species (ROS) induced apoptotic cell death. 4D-FastDIA-based mass spectrometry technology indicated that down-regulated modulator 1 (ROMO1) might be regarded targets NPs. Overexpression ROMO1 significantly reversed ROS-generation by ZIF-DHA, well pro-apoptosis effects. Taken together, our study elucidated highlighted framework-8-based MOF treat cancer. Our findings suggested NPs could an attractive strategy
Язык: Английский
Процитировано
15
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 170, С. 116059 - 116059
Опубликована: Дек. 28, 2023
The liver cancer has microenvironmental features such as low pH, M2 tumor-associated macrophage enrichment, oxygen, rich blood supply and susceptibility to hematotropic metastasis, high chemokine expression, enzyme overexpression, redox level, strong immunosuppression, which not only promotes the progression of disease, but also seriously affects clinical effectiveness traditional therapeutic approaches. However, nanotechnology, due its unique advantages size effect functionalized modifiability, can be utilized develop various responsive nano-drug delivery system (NDDS) by using these characteristic signals microenvironment a source stimulation, in turn realize intelligent release drug under specific microenvironment, significantly increase concentration at target site. Therefore, researchers have designed series stimuli-responsive NDDS based on characteristics hypoxia, weak acidity, abnormal expression proteases, they been widely investigated for improving anti-tumor efficacy reducing related side effects. This paper provides review current application progress developed response regulation treatment cancer, compares effects NDDS, reference building more advanced NDDS.
Язык: Английский
Процитировано
15
Antioxidants, Год журнала: 2024, Номер 13(3), С. 352 - 352
Опубликована: Март 15, 2024
Ferroptosis is an emerging type of regulated cell death usually accompanied by the accumulation ferrous ions (Fe2+) and lipid peroxides. As metabolic hub body, liver crucial for iron storage metabolism. The seems to be closely related ferroptosis through Liver disease greatly threatens host health, exploring effective interventions essential. Mounting studies have demonstrated that one possible pathogenic mechanisms involved in disease. Targeting may provide a promising opportunity treating However, drugs targeting are extremely limited. Therefore, it urgent need develop new safe regulators. Natural active compounds (NAC), especially those derived from traditional Chinese medicine, recently shown great therapeutic potential via modulating ferroptosis-related genes or pathways. Here, we outline molecular mechanism systematically summarize regulatory function NAC on Finally, discuss application prospects problems concerning as regulators managing
Язык: Английский
Процитировано
5
Biomaterials Research, Год журнала: 2025, Номер 29
Опубликована: Янв. 1, 2025
Tumors are the second most common cause of mortality globally, ranking just below heart disease. With continuous advances in diagnostic technology and treatment approaches, survival rates some cancers have increased. Nevertheless, due to complexity mechanisms underlying tumors, cancer remains a serious public health issue that threatens population globally. Manganese (Mn) is an essential trace element for human body. Its regulatory role tumor biology has received much attention recent years. Developments nanotechnology led emergence Mn-based nanoparticles great potential use diagnosis cancers. nanomaterials can be integrated with conventional techniques, including chemotherapy, radiation therapy, gene augment their therapeutic effectiveness. Further, play synergistic emerging strategies such as immunotherapy, photothermal photodynamic electromagnetic hyperthermia, sonodynamic chemodynamic intervention therapy. Moreover, enhance both precision diagnostics capability combined treatment. This article examines roles associated Mn field physiology biology, focus on application prospects
Язык: Английский
Процитировано
0
Frontiers in Bioscience-Landmark, Год журнала: 2023, Номер 28(11), С. 286 - 286
Опубликована: Ноя. 8, 2023
Oxidative stress (OS) is linked to hepatocellular carcinoma (HCC) progression. HCC may develop as a result of genetic changes, including oxidative injury both nuclear and mitochondrial DNA. Signaling pathways regulated by OS, such Wnt/β-catenin Notch pathways, are vital regulators in developing HCC. OS-mediated activation transcription factors, factor-κB p53, among others, capable regulating the redox state cells. OS also affects tumor microenvironment, which, turn, regulates In HCC, reactive oxygen species (ROS) can potentially enhance cell proliferation, metastasis, resistance treatment. However, elevated ROS levels cause cytotoxicity trigger apoptosis This review highlights explores potential stress-related treatment targets offering novel insights for clinical therapies.
Язык: Английский
Процитировано
12
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 95, С. 105604 - 105604
Опубликована: Март 21, 2024
Язык: Английский
Процитировано
4