Betaine alleviates doxorubicin-related cardiotoxicity via suppressing oxidative stress and inflammation via the NLRP3/SIRT1 pathway

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер 397(12), С. 9981 - 9990

Опубликована: Июль 2, 2024

Язык: Английский

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Demystifying the Role of Neuroinflammatory Mediators as Biomarkers for Diagnosis, Prognosis, and Treatment of Alzheimer’s Disease: A Review

ACS Pharmacology & Translational Science, Год журнала: 2024, Номер 7(10), С. 2987 - 3003

Опубликована: Сен. 26, 2024

Neuroinflammatory mediators play a pivotal role in the pathogenesis of Alzheimer's Disease (AD), influencing its onset, progression, and severity. The precise mechanisms behind AD are still not fully understood, leading current treatments to focus mainly on managing symptoms rather than preventing or curing condition. amyloid tau hypotheses most widely accepted explanations for pathology; however, they do completely account neuronal degeneration observed AD. Growing evidence underscores crucial neuroinflammation pathology neuroinflammatory hypothesis presents promising new approach understanding driving This review examines importance biomarkers diagnosis, prognosis, treatment It delves into underlying AD, highlighting involvement various such as cytokines, chemokines, ROS. Additionally, this discusses potential diagnostic tools, prognostic indicators, therapeutic targets management. By intricate interplay between pathology, aims help development efficient plans fight debilitating neurological Furthermore, it elaborates recent advancements neuroimaging techniques biofluid analysis identification monitoring patients.

Язык: Английский

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Phytic Acid Extraction from Rice Bran with Acetic Acid : Optimization, Antioxidant Capacity and Mechanism Based on Cellular Metabolomics

LWT, Год журнала: 2025, Номер unknown, С. 117394 - 117394

Опубликована: Янв. 1, 2025

Язык: Английский

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Electro-Acupuncture Therapy Alleviates Post-Stroke Insomnia by Regulating Sirt1 and the Nrf2-ARE Pathway

NeuroMolecular Medicine, Год журнала: 2025, Номер 27(1)

Опубликована: Май 17, 2025

Язык: Английский

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Phytic acid attenuates acetaminophen-induced hepatotoxicity via modulating iron-mediated oxidative stress and SIRT-1 expression in mice

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Май 1, 2024

Introduction: Administration of high doses acetaminophen (APAP) results in liver injury. Oxidative stress and iron overload play roles the pathogenesis APAP-induced hepatotoxicity. The present study assessed potential hepatoprotective effects phytic acid (PA), a natural antioxidant chelator, on hepatotoxicity possible underlying mechanism through its CYP2E1 gene expression, homeostasis, oxidative stress, SIRT -1 expression levels. Methods: Twenty-four adult male albino mice were used this study. Mice divided into four groups (six each group): control, APAP-treated, PA-treated APAP + groups. Liver function tests, serum tissue load evaluated all Hepatic homogenates to detect markers, including malondialdehyde (MDA) reduced glutathione (GSH). Histological hepatic evaluation immunohistochemistry performed. Quantitative real-time PCR was for assessment SIRT-1 expressions. biochemical structural changes reported. Results: PA administration showed beneficial improvements functions, decreased load, MDA, increased GSH, level improvement architecture. Conclusion: Conclusively, can be considered compound that attenuate acetaminophen-induced role as an chelator antioxidant, well up-regulation down-regulation CYP2E1.

Язык: Английский

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Exploring the mechanism of Schisandra rubriflora in the treatment of polycystic ovary syndrome based on network pharmacology and molecular docking

Journal of Ovarian Research, Год журнала: 2025, Номер 18(1)

Опубликована: Янв. 28, 2025

Polycystic ovary syndrome (PCOS) is an endocrine disease associated with reproductive and metabolic abnormalities. The aim of this study was to elucidate the effects Schisandra rubriflora (S. rubriflora) on PCOS its related mechanisms using network pharmacology, molecular docking in vitro experiments. HERB database SwissTargetPrediction were used obtain active components targets S. rubriflora. Differentially expressed genes (DEGs) obtained by analyzing GSE54248 dataset. A protein-protein interaction constructed, topological analyses performed identify hub main bioactive components. binding abilities between key studied docking. Finally, models constructed KGN cells rat ovarian granulosa cells, respectively, regulatory schisandrin, a component rubriflora, investigated assays. total 14 ingredients 26 potential therapeutic treatment obtained. Bioinformatics suggested that treating IL-17 signaling pathway TNF pathway. affinities (schisandrin, wyerone, rugosal) (PTGS2, MMP9, MCL1, JUN) high. Schisandrin could attenuate lipopolysaccharide-induced inflammation, oxidative stress, apoptosis as well inhibit target expression activation. PTGS2, MCL1 JUN are for treat PCOS. Schisandrin, may be candidate

Язык: Английский

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Pharmacological potential of calorie restriction mimetics in mitigating brain aging

Advances in pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Neuroprotective Effect of Perillyl alcohol in Sporadic Alzheimer’s disease in Rats

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177558 - 177558

Опубликована: Апрель 1, 2025

Язык: Английский

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Icariin attenuates oxidative stress via SIRT1/PGC-1α pathway in SAH mice

Experimental Neurology, Год журнала: 2025, Номер 390, С. 115303 - 115303

Опубликована: Май 8, 2025

Язык: Английский

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Therapeutic applications of exercise in neurodegenerative diseases: focusing on the mechanism of SIRT1

Molecular and Cellular Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 13, 2025

Язык: Английский

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