Cerebrovascular Diseases,
Год журнала:
2023,
Номер
53(4), С. 411 - 419
Опубликована: Сен. 29, 2023
<b><i>Introduction:</i></b>
The
present
study
was
to
investigate
the
clinical
role
of
miR-330-3p
in
acute
cerebral
infarction
(ACI),
including
its
diagnostic
and
prognostic
potential.
Preliminary
exploration
target
genes
archived
by
bioinformatics
analysis.
<b><i>Methods:</i></b>
plasma
patients
with
ACI
controls
were
quantified
real-time
quantitative
PCR.
1-month
prognosis
evaluated
Glasgow
Outcome
Scale
(GOS).
correlation
between
levels
GOS
scores
tested
Pearson
receiver
operating
characteristic
(ROC)
curves
established
based
on
expression
level
different
groups.
miR-330-3p-targeting
analyzed
using
Venn
diagram,
protein-protein
interaction
network,
Gene
Ontology
enrichment
<b><i>Results:</i></b>
significantly
increased
compared
that
healthy
controls,
ROC
curve
revealed
value
for
ACI.
poor
those
good
prognosis.
negatively
correlated
score,
suggesting
potential
predict
One-year
survival
analysis
surviving
had
lower
than
deceased.
proven
death
associated
synapse-related
terms.
<b><i>Conclusion:</i></b>
upregulated
ACI,
making
it
a
promising
marker
could
facilitate
synaptic
plasticity
following
infarction.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
175, С. 116703 - 116703
Опубликована: Май 6, 2024
The
distinctive
role
of
Yes-associated
protein
(YAP)
in
the
nervous
system
has
attracted
widespread
attention.
This
comprehensive
review
strategically
uses
retina
as
a
vantage
point,
embarking
on
an
extensive
exploration
YAP's
multifaceted
impact
from
to
brain
development
and
pathology.
Initially,
we
explore
crucial
roles
YAP
embryonic
cerebral
development.
Our
focus
then
shifts
retinal
development,
examining
detail
regulatory
influence
pigment
epithelium
(RPE)
progenitor
cells
(RPCs),
its
significant
effects
hierarchical
structure
functionality
retina.
We
also
investigate
essential
contributions
maintaining
homeostasis,
highlighting
precise
regulation
cell
proliferation
survival.
In
terms
retinal-related
diseases,
epigenetic
connections
pathophysiological
diabetic
retinopathy
(DR),
glaucoma,
proliferative
vitreoretinopathy
(PVR).
Lastly,
broaden
our
brain,
emphasizing
research
paradigm
"retina:
window
brain."
Special
is
given
emerging
studies
disorders
such
Alzheimer's
disease
(AD)
Parkinson's
(PD),
underlining
potential
therapeutic
value
neurodegenerative
neuroinflammation.
Biology of Sex Differences,
Год журнала:
2025,
Номер
16(1)
Опубликована: Апрель 2, 2025
Abstract
Background
Sexual
maturation
in
Atlantic
salmon
entails
a
transition
energy
utilization,
regulated
by
genes
and
environmental
stimuli
sex-specific
manner.
Males
require
less
energy,
the
form
of
adiposity,
to
mature
typically
younger
than
females.
Maturation
age
is
also
influenced
sex-dependent
fashion
vgll3
genotype
(
vestigial-like
3
),
co-factor
Hippo
pathway.
The
underlying
molecular
processes
age,
their
interplay
with
adiposity
genotypes,
remain
unclear.
Methods
To
elucidate
mechanisms
sex-
genotype-specific
differences,
we
investigated
association
early
(E)
late
(L)
alleles
transcription
>
330
involved
regulation
pathway
sexual
maturation,
related
signals
brain,
adipose,
gonads.
Results
strongest
effect
was
observed
adipose
for
females
brain
males,
highlighting
expression
differences
genotype.
Genes
ovarian
development
showed
increased
vgll3*EE
compared
vgll3*LL
Moreover,
males
exhibited
reduced
markers
pre-adipocyte
differentiation
lipolysis
yet
enhanced
adipocyte
lipid
storage.
Brain
gene
further
hormones
lipids,
as
well
tight
junction
assembly.
Conclusions
Overall,
these
patterns
point
towards
greater
storage
slower
utilization
males.
These
results
suggest
Hippo-dependent
may
be
important
mediators
sex
salmon.
Molecules,
Год журнала:
2023,
Номер
28(18), С. 6501 - 6501
Опубликована: Сен. 7, 2023
The
gut–brain
axis
is
an
active
area
of
research.
Several
representative
diseases,
including
central
nervous
system
disorders
(Alzheimer’s
disease,
Parkinson’s
and
depression),
metabolic
(obesity-related
diseases),
intestinal
(inflammatory
bowel
disease
dysbiosis),
are
associated
with
the
dysfunctional
axis.
Baicalin,
a
bioactive
flavonoid
extracted
from
Scutellaria
baicalensis,
reported
to
exert
various
pharmacological
effects.
This
narrative
review
summarizes
molecular
mechanisms
potential
targets
baicalin
in
Baicalin
protects
through
anti-neuroinflammatory
anti-neuronal
apoptotic
effects,
suppresses
obesity
anti-inflammatory
antioxidant
alleviates
regulatory
effects
on
microorganisms
short-chain
fatty
acid
production.
bioactivities
mediated
comprehensively
role
disorders,
laying
foundation
for
future
research,
although
further
confirmatory
basic
research
required.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 452 - 452
Опубликована: Янв. 7, 2025
The
tissue
specificity
of
DNA
methylation
refers
to
the
significant
differences
in
patterns
different
tissues.
This
regulates
gene
expression,
thereby
supporting
specific
functions
each
and
maintenance
normal
physiological
activities.
Abnormal
tissue-specific
are
closely
related
age-related
diseases.
abnormal
pattern
affects
regulation
which
may
lead
changes
cell
function
promote
occurrence
pathological
conditions.
By
analyzing
these
patterns,
key
CpG
sites
for
disease
diagnosis
can
be
effectively
screened.
main
goal
this
paper
is
use
characteristics
associated
with
expression
construct
an
model.
First,
we
combined
chi-square
tests
logistic
regression
identify
disease-specific
sites,
laying
foundation
accurate
medical
diagnosis,
verified
biological
relevance
through
enrichment
analysis.
Then
used
Transformer
model
fit
realized
automatic
Our
work
proves
that
has
potential
diagnose
diseases,
scientific
nature
our
proposed
diagnostic
method
from
a
perspective.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 25, 2025
Epilepsy
and
seizures
are
characterized
by
neuronal
hyperexcitability
damage,
influenced
metabolic
dysregulation,
neuroinflammation,
oxidative
stress.
Despite
available
treatments,
many
patients
remain
resistant
to
therapy,
necessitating
novel
therapeutic
strategies.
Klotho,
a
neuroprotective,
anti-inflammatory,
antioxidative
protein
has
emerged
as
potential
modulator
of
epilepsy-related
pathways.
This
study
investigates
the
physostigmine
analogues
in
regulating
Klotho
expression
its
downstream
targets
epilepsy.
An
integrative
vitro
vivo
approach
was
employed
PTZ-induced
kindled
mice.
Behavioral
assessments,
including
Morris
Water
Maze
(MWM),
Rota
Rod,
Black
White
Box,
Tail
Suspension
tests
were
conducted.
Biochemical
analyses
quantified
serum
glucose,
lipid
profiles,
pro-inflammatory
cytokines
(TNF-α,
FOXO1),
apoptotic
proteins
(caspase-3).
Quantitative
real-time
PCR
(qRT-PCR)
performed
assess
epilepsy-associated
gene
(STAT3,
Bax,
Bcl2).
The
synthesized
exhibited
varying
inhibitory
effects
on
transcriptional
activators,
with
Compound
C
(1,8-bis(phenylsulfonyl)-1,8-dihydropyrrolo
[2,3-b]
indole)
showing
weakest
inhibition
(IC50
=
1.31
µM).
In
vivo,
demonstrated
anticonvulsant
(p
<
0.05),
neuroprotective
(5
mg/kg,
p
0.05,
10
0.01,
20
mg/kg
0.0001),
antidepressant
anti-inflammatory
0.05)
seizure
models,
improving
motor
function
0.001),
cognitive
performance
0.01),
reducing
neuroinflammatory/metabolic
markers
while
modulating
STAT3
BAX
Bcl2
expression.
1,8-bis(phenylsulfonyl)-1,8-dihydropyrrolo
indole
epilepsy
via
modulation
observed.
Targeting
metabolic,
inflammatory,
pathways
presents
promising
strategy
for
management.
Further
research
is
required
optimize
clinical
translation
ensure
long-term
efficacy
safety.
