Is Intrinsic Cardioprotection a Laboratory Phenomenon or a Clinically Relevant Tool to Salvage the Failing Heart? DOI Open Access
T Ravíngerová, Adriana Adameová, Lubomir Lonek

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(22), С. 16497 - 16497

Опубликована: Ноя. 18, 2023

Cardiovascular diseases, especially ischemic heart disease, as a leading cause of failure (HF) and mortality, will not reduce over the coming decades despite progress in pharmacotherapy, interventional cardiology, surgery. Although patients surviving acute myocardial infarction live longer, alteration function later lead to HF. Its rising incidence represents danger, among elderly, with data showing more unfavorable results females than males. Experiments revealed an infarct-sparing effect "preconditioning" (IPC) most robust form innate cardioprotection based on heart's adaptation moderate stress, increasing its resistance severe insults. However, translation clinical practice is limited by technical requirements time. Novel forms adaptive interventions, such "remote" IPC, have already been applied patients, albeit different effectiveness. Cardiac tolerance can also be increased other noninvasive approaches, hypoxia- or exercise-induced preconditioning. their molecular mechanisms are yet fully understood, some modalities appear promising novel strategies for fighting HF through targeting numerous mechanisms. In this review, we discuss injury repair, well interventions that potential used treatment patients.

Язык: Английский

Cinnamaldehyde mitigates acute myocardial infarction by regulating ferroptosis through the PI3K-AKT signaling pathway DOI
Ming Yang, Dongming Lin,

Liming He

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 150, С. 114262 - 114262

Опубликована: Фев. 11, 2025

Язык: Английский

Процитировано

2
A rapamycin-loading platelet membrane hybrid liposome with anti-inflammation effect and long-lasting repair capability for acute kidney injury DOI
Miaomiao Zhang, Li Yang, Tongyang Xu

и другие.

Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 927 - 942

Опубликована: Фев. 21, 2025

Язык: Английский

Процитировано

1
Cinnamaldehyde Alleviates Aspirin-Induced Gastric Mucosal Injury by regulating PI3K/AKT Pathway-Mediated Apoptosis, Autophagy, and Ferroptosis DOI Creative Commons

Shuguang Yan,

Shengchuan Bao,

Ting Chen

и другие.

Phytomedicine, Год журнала: 2024, Номер 132, С. 155791 - 155791

Опубликована: Май 29, 2024

Gastric mucosal injury is a chronic and progressive stomach disease that can be caused by nonsteroidal anti-inflammatory drugs (NSAIDs). Therefore, there an urgent need to find safe effective prevent gastric due NSAIDs. Cinnamaldehyde (CA) bioactive compound extracted from the rhizome of cinnamon has various pharmacological functions, including anti-inflammatory, analgesic, antiapoptotic, antioxidant activities. However, potential effect CA on remains unknown.

Язык: Английский

Процитировано

7
NLGN3 Contributes to Angiogenesis in Myocardial Infarction Via Activation of the Gαi1/3-Akt Pathway Short Tittle: Nlgn3 Contributes Angiogenesis DOI
Shubin Qiao, Chao Tang,

Dejin Zhan

и другие.

Опубликована: Янв. 1, 2025

Aims: Angiogenesis is an important repair mechanism for myocardial infarction. Neuroligin-3 (NLGN3) can promote angiogenesis by activating Gαi1/3-Akt signaling following ischemic brain injury. This study investigated the role of NLGN3 in infarction (MI).

Язык: Английский

Процитировано

0
The Protective Role of Cinnamaldehyde in Kidney Injury: Modulation of NF-κB and PI3K/Akt Signaling Pathways DOI
Sachit Sharma,

Astha Sharma,

Sandip Tejpal

и другие.

Journal for Research in Applied Sciences and Biotechnology, Год журнала: 2025, Номер 4(1), С. 132 - 141

Опубликована: Фев. 28, 2025

Chronic renal disease is defined as the presence of kidney damage or impaired function over a period at least three months, regardless origin condition. Numerous factors, including oxidative stress, inflammation, and cell death, are frequently responsible for acute chronic injury, which significant issue in field global health. Because crucial functions that they play, NF-κB PI3K/Akt signaling pathways potential therapeutic targets. These pathogenic processes mediated by these pathways. cinnamonaldehyde, naturally occurring bioactive component, has demonstrated encouraging nephroprotective properties. properties attributed to fact it contains anti-inflammatory, antioxidant, anti-apoptotic The purpose this review investigate molecular role cinnamaldehyde preventing modulating Within article, we examine involved highlight treatment disease. Although preclinical studies have protective effects, additional research, clinical trials, required validate its safety, effectiveness, uses management illness people.

Язык: Английский

Процитировано

0
Influence and molecular mechanism of cinnamaldehyde against ventricular arrhythmia via the TAK1-p38MAPK-NLRP3 pathway DOI Creative Commons
Guoping Ma, Mian Li,

Wanyue Yang

и другие.

Heart and Vessels, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Abstract Based on the transforming growth factor β-activated kinase 1 (TAK1)-p38 mitogen-activated protein (p38MAPK)-nucleotide-binding oligo-like receptor 3 (NLRP3) signalling pathway, protective effect and mechanism of isoproterennaline (ISO)-induced cinnamaldehyde inflammatory injury in ventricular rats were investigated. Fifty male SPF SD randomly assigned to normal group, model propranolol low-dose group or high-dose group. The arrhythmia was constructed using "6 + 1" ISO injection method. given 15 mg·(kg d) −1 , those low groups 20 50 respectively, control received an equal volume 0.9% NaCl solution. Changes serum troponin (cTnI), creatine isoenzyme (CK-MB), interleukin-1β (IL-1β) levels determined by ELISA. HE staining used observe tissue morphology heart disease. mRNA expression IL-1β NLRP3 RT‒PCR. Mitochondrial damage observed transmission electron microscopy. reactive oxygen species (ROS) detected immunofluorescence. Western blot immunohistochemical detection IL-1β, NLRP3, TAK1, phospho-TAK1 (p-TAK1), p38MAPK, phospho-p38MAPK (p-p38MAPK), nuclear factor-κB (NF-κB),and phospho-NF-κB (p-NF-κB) also performed. Data analysis performed SPSS 25.0 software. In rats, there no obvious arrhythmias ECG, cardiac mitochondria basically normal, level low, myocardial ROS, p-TAK1, p-p38MAPK p-NF-κB weak. Compared with had significant increases scores according ECG ( P < 0.01). Myocardial histopathological injury, weight index (HWI) cTnI CK-MB Additionally, mitochondrial tissue, increased ROS fluorescence intensity, elevated detected( inflammation-related factors 0.01 0.05). decreased three treatment Cardiac significantly improved, HWI injury-related indicators decreased( Damaged p-p38MAPK, decreased. TAK1-p38MAPK-NLRP3 is enhanced arrhythmia. Cinnamaldehyde can regulate signalling, reduce cardiomyocyte pyroptosis, antagonize protect cardiomyocytes inhibiting oxidative stress.

Язык: Английский

Процитировано

0
Modular-Based Synergetic Mechanisms of Jasminoidin and Ursodeoxycholic Acid in Cerebral Ischemia Therapy DOI Creative Commons
Jing’ai Wang, Qikai Niu, Yanan Yu

и другие.

Biomedicines, Год журнала: 2025, Номер 13(4), С. 938 - 938

Опубликована: Апрель 11, 2025

Objectives: Jasminoidin (JA) and ursodeoxycholic acid (UA) have been shown to exert synergistic effects on cerebral ischemia (CI) therapy, but the underlying mechanisms remain be elucidated. Objective: To elucidate involved in combined use of JA UA (JU) for CI therapy using a driver-induced modular screening (DiMS) strategy. Methods: Network proximity topology-based approaches were used identify modules driver genes from an anti-ischemic microarray dataset (ArrayExpress, E-TABM-662). A middle artery occlusion/reperfusion (MCAO/R) model was established 30 Sprague Dawley rats, divided into sham, vehicle, (25 mg/mL), (7 JU (JA:UA = 1:1) groups. After 90 minutes ischemia, infarct volume neurological deficit scores evaluated. Western blotting performed 24 h after administration validate key protein changes. Results: Six, eleven, four drug-responsive On_modules identified JA, UA, JU, respectively. Three (Sy-modules, JU-Mod-7, 8, 10) 12 (e.g., NRF1, FN1, CUL3) identified, mainly involving PI3K-Akt MAPK pathways regulation actin cytoskeleton. synergistically reduced score (2.5, p < 0.05) MCAO/R rats. In vivo studies demonstrated that suppressed expression CUL3, ITGA4, while it increased NRF1. Conclusions: acts CI–reperfusion injury by regulating NRF1 inducing PI3K-Akt, MAPK, cytoskeleton pathways. DiMS provides new approach uncover combination therapies.

Язык: Английский

Процитировано

0
Traditional Chinese Medicine YangxinDingji alleviates arrhythmias through inhibition of sodium and L-type calcium channels DOI

Suhua Qiu,

Jinglei Sun,

Shi Su

и другие.

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119803 - 119803

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
The impact of Astragaloside IV on the inflammatory response and gut microbiota in cases of acute lung injury is examined through the utilization of the PI3K/AKT/mTOR pathway DOI Creative Commons

Cheng Luo,

Yuanhang Ye,

Anqi Lv

и другие.

PLoS ONE, Год журнала: 2024, Номер 19(7), С. e0305058 - e0305058

Опубликована: Июль 2, 2024

Objectives Astragaloside IV (AS-IV) is a natural triterpenoid saponin compound with variety of pharmacological effects, and several studies have clarified its anti-inflammatory which may make it an effective alternative treatment against inflammation. In the study, we aimed to investigate whether AS-IV could attenuate inflammatory response acute lung injury mechanisms. Methods Different doses (20mg·kg -1 , 40mg·kg 80mg·kg ) were administered ALI rat model, followed by collection serum broncho alveolar lavage fluid (BALF) for examination response, HE staining colon tissues, interpretation potential molecular mechanisms quantitative real-time PCR (qRT-PCR), Western blotting (WB). addition, fecal samples from rats collected analyzed 16S rRNA sequencing. Results decreased levels TNF-α, IL-6, IL-1β in BALF mice Acute (ALI). Lung histopathology confirmed that alleviated infiltration, tissue edema, structural changes. qRT-PCR WB showed mainly improved inflammation inhibiting expression PI3K, AKT mTOR mRNA, disorder intestinal microflora increasing number beneficial bacteria reducing harmful bacteria. Conclusion reduces factors PI3K/AKT/mTOR pathway optimizes composition gut AIL rats.

Язык: Английский

Процитировано

3
Design and synthesis of 3,4-seco-lupane triterpene derivatives to resist myocardial ischemia-reperfusion injury by inhibiting oxidative stress-mediated mitochondrial dysfunction via the PI3K/AKT/HIF-1α axis DOI Open Access

Hongbo Teng,

Di Wu,

Lu Luo

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 167, С. 115452 - 115452

Опубликована: Сен. 8, 2023

In this study, 86 new seco-lupane triterpenoid derivatives were designed, synthesized, and characterized, their protective activities against ischemia-reperfusion injury investigated in vitro vivo. Structure-activity relationship studies revealed that most target compounds could protect cardiomyocytes hypoxia/reoxygenation-induced vitro, with compound 85 being the active exhibiting more potent activity than clinical first-line drugs. Furthermore, all thiophene exhibited stronger furan, pyridine, pyrazine derivatives, gradually increased extension of alkyl chain changed substituent. The data from in-vitro in-vivo experiments protected mitochondria damage by inhibiting excessive production oxidative stressors, such as intracellular ROS, which turn inhibited apoptosis necrotize reduced infarct size, thereby protecting normal cardiac function. It was associated enhanced activation PI3K/AKT-mediated HIF-1α signaling pathway. Therefore, acts an stress inhibitor, blocks ROS production, protects cells myocardial ischemia/reperfusion (MI/R) injury, represents effective drug for treating MI/R injury.

Язык: Английский

Процитировано

7