Опубликована: Янв. 26, 2024
Язык: Английский
Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)
Опубликована: Фев. 7, 2025
Cardiovascular diseases represent the principal cause of death and comorbidity among people with diabetes. Ferroptosis, an iron-dependent non-apoptotic regulated cellular characterized by lipid peroxidation, is involved in pathogenesis diabetic cardiovascular diseases. The susceptibility to ferroptosis hearts possibly related myocardial iron accumulation, abnormal metabolism excess oxidative stress under hyperglycemia conditions. Accumulating evidence suggests can be therapeutic target for This review summarizes ferroptosis-related mechanisms novel choices targeting pathways. Further study on ferroptosis-mediated cardiac injury enhance our understanding pathophysiology provide more potential choices.
Язык: Английский
Процитировано
3
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 173, С. 116386 - 116386
Опубликована: Март 16, 2024
Diffuse large B-cell lymphoma (DLBCL), a heterogeneous lymphoid malignancy, poses significant threat to human health. The standard therapeutic regimen for patients with DLBCL is rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP), typical cure rate of 50–70%. However, some either relapse after complete remission (CR) or exhibit resistance R-CHOP treatment. Therefore, novel approaches are imperative managing high-risk refractory DLBCL. Ferroptosis driven by iron-dependent phospholipid peroxidation, process that relies on the transition metal iron, reactive oxygen species (ROS), phospholipids containing polyunsaturated fatty acids-containing (PUFA-PLs). Research indicates ferroptosis implicated in various carcinogenic anticancer pathways. Several hematological disorders heightened sensitivity cell death induced ferroptosis. cells, particular, demonstrate an increased demand iron upregulation expression acid synthase. Additionally, there exists correlation between ferroptosis-associated genes prognosis may be promising target therapy. In this review, we elucidate mechanisms, its role DLBCL, potential targets This review offers insights into application treatment strategies
Язык: Английский
Процитировано
13
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown
Опубликована: Авг. 28, 2024
Язык: Английский
Процитировано
10
Biomedicines, Год журнала: 2025, Номер 13(2), С. 485 - 485
Опубликована: Фев. 16, 2025
The intersection of COVID-19 and cardiovascular disease (CVD) has emerged as a significant area research, particularly in understanding the impact antiplatelet therapies like ticagrelor clopidogrel. been associated with acute complications, including myocardial infarction, thrombosis, heart failure, exacerbated by virus's ability to trigger widespread inflammation endothelial dysfunction. MicroRNAs (miRNAs) play critical role regulating these processes modulating gene expressions involved platelet function, inflammation, vascular homeostasis. This study explores potential miRNAs such miR-223 miR-126 biomarkers for predicting resistance or responsiveness patients disease. Identifying miRNA signatures linked drug efficacy could optimize treatment strategies at high risk thrombotic events during infection. Moreover, miRNA-mediated pathways offers new insights into how SARS-CoV-2 exacerbates CVD, through mechanisms cytokine storms damage. findings this research lead personalized therapeutic approaches, improving patient outcomes reducing mortality COVID-19-associated events. With global implications, addresses urgent need effective management CVD context COVID-19, focusing on integration molecular enhance precision therapy.
Язык: Английский
Процитировано
2
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 172, С. 116235 - 116235
Опубликована: Фев. 3, 2024
The pivotal regulatory role of non-coding RNAs (ncRNAs), especially exosomal ncRNAs, in ferroptosis significantly influences cancer cell fate. This review explores their involvement across various human cancers, focusing on microRNAs (miRNA), long (lncRNA), and circular (circRNA). These ncRNAs either stimulate or inhibit by targeting key components, impacting susceptibility to this form death. Specific studies lung, gastric, liver, cervical, bladder, pancreatic, osteosarcoma cancers underscore the crucial modulating ferroptosis, influencing progression, therapeutic responses. Emphasizing potential we discuss ability deliver circRNA, miRNA, lncRNA target cells. Despite being early stages with challenges bioengineering for drug delivery, these hold promise future clinical applications. Noteworthy findings include inhibiting exosome production overcome resistance lung adenocarcinoma DACT3-AS1 sensitize gastric cells ferroptosis. concludes highlighting like miR-4443 miR-660–5p as promising targets, offering avenues precise interventions signaling pathways sensitizing Overall, enhances our understanding pathogenesis presents new horizons targeted interventions, revealing intricate interplay between
Язык: Английский
Процитировано
5
Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12
Опубликована: Фев. 7, 2024
Ferroptosis, an iron-dependent form of programmed cell death, introduces a novel perspective on cellular demise. This study investigates the regulatory network exosomal non-coding RNAs (ncRNAs), including miRNAs, circRNAs, and lncRNAs, in ferroptosis modulation. The primary goal is to examine pathological roles ferroptosis-related ncRNAs, particularly ischemic reperfusion injuries. research reveals intricate molecular interactions governing interplay between ncRNAs ferroptosis, elucidating their diverse different non-malignant contexts. Attention given impact diseases, cardiac, cerebral, liver, kidney injuries, as well lung, wound, neuronal Beyond theoretical exploration, provides insights into potential therapeutic applications, emphasizing significance mesenchymal stem cells (MSCs)-derived exosomes. Findings underscore pivotal role MSC-derived modulating responses related regulation, introducing cutting-edge dimension. recognition emphasizes importance exosomes crucial mediators with broad implications. Insights unveil promising avenues for targeted interventions, capitalizing providing comprehensive foundation future strategies.
Язык: Английский
Процитировано
5
Journal of Medical Virology, Год журнала: 2025, Номер 97(4)
Опубликована: Апрель 1, 2025
ABSTRACT The membrane protein (M), a key structural of SARS‐CoV‐2 that regulates virus assembly and morphogenesis, is involved in the pathological processes multiple organ damage metabolic disorders. This study aims to elucidate mechanisms M‐mediated host ferroptosis lipid accumulation during infection. Here, we detected M enhances cellular sensitivity ferroptosis. Additionally, uncovered pivotal role perilipin‐2 sterol regulatory element‐binding 1 M‐induced accumulation. Xanthohumol, cost‐effective orally available diacylglycerol acyltransferase inhibitor, alleviated triglyceride total cholesterol accumulation, thereby counteracting Furthermore, identified mitochondrial import inner translocase subunit TIM23 receptor TOM20 homolog contribute dysfunction. Notably, inhibiting synthesis effectively reduced reactive oxygen species transmembrane potential, indicating cross‐talk between ferro pathways. Mechanistically, glutathione peroxidase 4 (GPX4) interacts with M, leading its subsequent degradation by Membrane Associated Ring‐CH‐Type Finger (MARCHF1) ubiquitin ligase. M‐GPX4 interaction occurs at R72 residue, which may represent potential therapeutic target against modulates further impairs functions, ultimately resulting through MARCHF1‐GPX4 axis. Disrupting host‐virus interactions along this pathway provide strategy for
Язык: Английский
Процитировано
0
Critical Care, Год журнала: 2023, Номер 27(1)
Опубликована: Дек. 4, 2023
Abstract The multiple roles of iron in the body have been known for decades, particularly its involvement overload diseases such as hemochromatosis. More recently, compelling evidence has emerged regarding critical role non-transferrin bound (NTBI), also catalytic iron, care critically ill patients intensive units (ICUs). These trace amounts constitute a small percentage serum yet they are heavily implicated exacerbation diseases, primarily by catalyzing formation reactive oxygen species, which promote oxidative stress. Additionally, activates macrophages and facilitates growth pathogens. This review aims to shed light on this underappreciated phenomenon explore various common sources NTBI ICU patients, lead transient dysregulation during acute phases disease. Iron serves linchpin vicious cycle many pathologies that often multifactorial. clinical showing detrimental impact patient outcomes will be outlined major pathologies. Finally, different therapeutic strategies reviewed, including targeting proteins involved metabolism, conventional chelation therapy, combination renal replacement therapy with therapy.
Язык: Английский
Процитировано
8
Heliyon, Год журнала: 2024, Номер 10(17), С. e36567 - e36567
Опубликована: Авг. 24, 2024
The coronavirus disease 2019 (COVID-19) was caused by severe acute respiratory syndrome 2 (SARS-CoV-2), which led to a huge mortality rate and imposed significant costs on the health system, causing damage cells of different organs such as heart. However, exact details mechanisms behind this are not clarified. Therefore, we aimed identify cell molecular mechanism heart SARS-Cov-2 infection.
Язык: Английский
Процитировано
1
Опубликована: Янв. 26, 2024
Язык: Английский
Процитировано
0