Lung
cancer
is
one
of
the
deadliest
malignancies
worldwide,
with
distant
metastasis
being
a
major
cause
death.
However,
specific
mechanisms
lung
remain
unclear.
NcRNAs,
widely
present
type
non-coding
RNAs
in
body,
constitute
about
98%
human
genome,
lacking
protein-coding
capacity
but
involved
various
cellular
processes
such
as
proliferation,
apoptosis,
invasion,
and
migration.
Studies
have
shown
that
ncRNAs
play
crucial
role
cancer,
although
research
this
area
limited.
This
review
summarizes
biological
origins
functions
ncRNAs,
their
roles
metastasis,
discusses
potential
for
early
screening
therapeutic
applications
cancer.
Furthermore,
it
outlines
challenges
translating
basic
advancements
into
clinical
practice.
Cancers,
Год журнала:
2024,
Номер
16(8), С. 1554 - 1554
Опубликована: Апрель 18, 2024
Cancer
is
a
life-threatening
disease
and
one
of
the
leading
causes
death
worldwide.
Despite
significant
advancements
in
therapeutic
options,
most
available
anti-cancer
agents
have
limited
efficacy.
In
this
context,
natural
compounds
with
diverse
chemical
structures
been
investigated
for
their
multimodal
properties.
Curcumin
polyphenol
isolated
from
rhizomes
Curcuma
longa
has
widely
studied
its
anti-inflammatory,
anti-oxidant,
effects.
acts
on
regulation
different
aspects
cancer
development,
including
initiation,
metastasis,
angiogenesis,
progression.
The
phosphatidylinositol-3-kinase
(PI3K)/protein
kinase
B
(AKT)
pathway
key
target
therapy,
since
it
implicated
proliferation,
cell
survival.
found
to
inhibit
PI3K/Akt
tumor
cells,
primarily
via
mediators,
growth
factors,
protein
kinases,
cytokines.
This
review
presents
potential
curcumin
malignancies,
such
as
glioblastoma,
prostate
breast
cancer,
head
neck
cancers,
through
targeting
signaling
pathway.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 796 - 796
Опубликована: Янв. 18, 2025
Topoisomerase
II
inhibitors,
particularly
etoposide,
have
long
been
integral
to
the
treatment
of
lung
cancer,
especially
small
cell
cancer.
This
review
comprehensively
examines
mechanisms
action
its
clinical
efficacy,
and
role
in
current
cancer
regimens.
Etoposide
exerts
anticancer
effects
by
inducing
DNA
strand
breaks
through
inhibition
topoisomerase
II,
leading
apoptosis.
Despite
their
widespread
use,
challenges
such
as
drug
resistance,
toxicity,
limited
efficacy
non-small
spurred
ongoing
research
on
combination
therapies
novel
formulations.
Emerging
therapeutic
strategies
include
integration
etoposide
with
immunotherapy,
targeted
therapies,
delivery
systems
aimed
at
enhancing
window
overcoming
resistance.
article
aims
inform
development
more
effective
providing
a
critical
overview
applications
exploring
future
directions
for
therapy.
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 14, 2025
Abstract
Lung
cancer
remains
the
leading
cause
of
cancer-related
mortality
globally,
necessitating
continual
exploration
novel
therapeutic
targets.
The
phosphoinositide
3-kinase
(PI3K)
signaling
pathway
plays
a
pivotal
role
in
oncogenic
processes,
including
cell
growth,
survival,
metabolism
and
immune
modulation.
This
comprehensive
review
delineates
distinct
roles
PI3K
subtypes—PI3Kα,
PI3Kβ,
PI3Kγ
PI3Kδ—in
lung
pathogenesis
progression.
We
evaluate
current
landscape
inhibitors,
transitioning
from
non-selective
early-generation
compounds
to
isoform-specific
agents,
highlighting
their
clinical
efficacy,
resistance
mechanisms
potential
combination
strategies.
Furthermore,
intricate
interplay
between
tumor
microenvironment
is
explored,
elucidating
how
modulation
can
enhance
immunotherapeutic
responses.
Metabolic
reprogramming
driven
by
also
dissected,
revealing
vulnerabilities
that
be
therapeutically
exploited.
Despite
promising
advancements,
challenges
such
as
adverse
effects
underscore
need
for
personalized
medicine
approaches
development
next-generation
inhibitors.
underscores
multifaceted
advocates
integrated
strategies
harness
its
full
potential,
paving
way
improved
patient
outcomes.
Marine Drugs,
Год журнала:
2024,
Номер
22(3), С. 101 - 101
Опубликована: Фев. 23, 2024
Non-small-cell
lung
cancer
(NSCLC),
the
most
commonly
diagnosed
and
leading
cause
of
cancer-related
death
worldwide,
has
been
extensively
investigated
in
last
decade
terms
developing
new
therapeutic
options
that
increase
patient
survival.
In
this
context,
marine
animals
are
a
source
new,
interesting
bioactive
molecules
have
applied
to
treatment
different
types
cancer.
Many
efforts
made
search
for
strategies
improve
prognosis
patients,
including
compounds
cytotoxic
drugs
from
sponges.
Their
antitumoral
effect
can
be
explained
by
several
cellular
molecular
mechanisms,
such
as
modulation
cell
cycle
or
induction
apoptosis.
Thus,
systematic
review
aims
summarize
derived
sponges
mechanisms
which
they
show
antitumor
effects
against
cancer,
exploring
their
limitations
challenges
associated
with
discovery.
The
process
was
performed
three
databases
(PubMed,
SCOPUS,
Web
Science),
yielding
total
105
articles
identified
10
years,
after
screening
process,
33
were
included
review.
results
showed
these
natural
sponge-derived
valuable
inspiration
development
drugs.
However,
more
research
field
is
needed
translation
novel
clinic.
Cancer Epidemiology,
Год журнала:
2024,
Номер
93, С. 102693 - 102693
Опубликована: Ноя. 13, 2024
Lung
cancer
continues
to
pose
a
serious
global
public
health
challenge.
Timely
evidence
on
the
epidemiological
profile
of
disease
is
crucial
facilitate
implementation
lung
control
efforts.
This
study
provides
updated
estimates
for
incidence
and
mortality
in
2022,
along
with
projections
new
cases
deaths
up
2050.
Pharmaceutics,
Год журнала:
2024,
Номер
16(8), С. 969 - 969
Опубликована: Июль 23, 2024
Lung
cancer
is
the
leading
cause
of
cancer-related
mortality
worldwide,
largely
due
to
limited
efficacy
anticancer
drugs,
which
primarily
attributed
insufficient
doses
reaching
lungs.
Additionally,
patients
undergoing
treatment
experience
severe
systemic
adverse
effects
distribution
drugs
non-targeted
sites.
In
light
these
challenges,
there
has
been
a
growing
interest
in
pulmonary
administration
for
lung
cancer.
This
route
allows
be
delivered
directly
lungs,
resulting
high
local
concentrations
that
can
enhance
antitumor
while
mitigating
toxic
effects.
However,
poses
challenge
overcoming
mechanical,
chemical,
and
immunological
defenses
respiratory
tract
prevent
inhaled
drug
from
properly
penetrating
To
overcome
drawbacks,
use
nanoparticles
inhaler
formulations
may
promising
strategy.
Nanoparticles
assist
minimizing
clearance,
increasing
penetration
into
epithelium,
enhancing
cellular
uptake.
They
also
facilitate
increased
stability,
promote
controlled
release,
delivery
target
sites,
such
as
tumor
environment.
Among
them,
chitosan-based
demonstrate
advantages
over
other
polymeric
nanocarriers
their
unique
biological
properties,
including
activity
mucoadhesive
capacity.
These
properties
have
potential
when
administered
via
route.
view
above,
this
paper
provides
an
overview
research
conducted
on
drug-loaded
incorporated
devices
Furthermore,
article
addresses
emerging
technologies,
siRNA
(small
interfering
RNA),
context
therapy.
Particularly,
recent
studies
employing
are
described.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(20), С. 11325 - 11325
Опубликована: Окт. 21, 2024
The
Greek
roots
of
the
word
"photodynamic"
are
as
follows:
"phos"
(φω~ς)
means
"light"
and
"dynamis"
(δύναμις)
"force"
or
"power".
Photodynamic
therapy
(PDT)
is
an
innovative
treatment
method
based
on
ability
photosensitizers
to
produce
reactive
oxygen
species
after
exposure
light
that
corresponds
absorbance
wavelength
photosensitizer,
either
in
visible
near-infrared
range.
This
process
results
damage
pathological
cancer
cells,
while
minimizing
impact
healthy
tissues.
PDT
a
promising
direction
many
diseases,
with
particular
emphasis
fight
against
other
diseases
associated
excessive
cell
growth.
power
contributed
creation
phototherapy,
whose
history
dates
back
ancient
times.
It
was
then
noticed
some
substances
exposed
sun
have
negative
effect
body,
others
therapeutic
effect.
work
provides
detailed
review
photodynamic
therapy,
from
its
origins
present
day.
surprising
how
seemingly
simple
beam
can
such
powerful
healing
effect,
which
used
not
only
dermatology,
but
also
oncology,
surgery,
microbiology,
virology,
even
dentistry.
However,
despite
results,
still
faces
challenges.
Moreover,
requires
further
research
improvement.
