Molecular Mechanisms Linking Omega-3 Fatty Acids and the Gut–Brain Axis DOI Creative Commons

Anna Zinkow,

Wojciech Grodzicki,

Malwina Czerwińska

et al.

Molecules, Journal Year: 2024, Volume and Issue: 30(1), P. 71 - 71

Published: Dec. 28, 2024

The gut–brain axis (GBA) is a complex communication network connecting the gastrointestinal tract (GIT) and central nervous system (CNS) through neuronal, endocrine, metabolic, immune pathways. Omega-3 (n-3) fatty acids, particularly eicosapentaenoic acid (EPA) docosahexaenoic (DHA), are crucial food components that may modulate function of this molecular mechanisms. Derived mainly from marine sources, these long-chain polyunsaturated acids integral to cell membrane structure, enhancing fluidity influencing neurotransmitter signal transduction. Additionally, n-3 inflammation by altering eicosanoid production, reducing proinflammatory cytokines, promoting anti-inflammatory mediators. These actions help preserve integrity cellular barriers like intestinal blood–brain barriers. In CNS, EPA DHA support neurogenesis, synaptic plasticity, neurotransmission, improving cognitive functions. They also regulate hypothalamic–pituitary–adrenal (HPA) excessive cortisol associated with stress responses mental health disorders. Furthermore, influence composition gut microbiota, beneficial bacterial populations abundance contribute improve systemic immunity. Their multifaceted roles within GBA underscore their significance in maintaining homeostasis supporting well-being.

Language: Английский

Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 270 - 270

Published: Feb. 12, 2025

The gut-brain-cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, cancer progression. Recent advances have accentuated significant role of microbiota metabolites in modulating systemic processes that influence both brain health tumorigenesis. This paper explores emerging concept metabolite-mediated modulation within connection, focusing on key such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, lipopolysaccharides (LPS). While microbiota's impact immune regulation, neuroinflammation, tumor development is well established, gaps remain grasping how specific contribute to neuro-cancer interactions. We discuss with potential implications for neurobiology cancer, indoles polyamines, which yet be extensively studied. Furthermore, we review preclinical clinical evidence linking dysbiosis, altered metabolite profiles, tumors, showcasing limitations research gaps, particularly human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal transplantation, probiotics, demonstrate promise but also indicate hurdles translating these findings therapies. concludes call standardized multi-omics approaches bi-directional frameworks integrating microbiome, neuroscience, oncology develop personalized therapeutic strategies patients.

Language: Английский

Citations

1
Chitosan and its derivatives: A novel approach to gut microbiota modulation and immune system enhancement DOI
Great Iruoghene Edo, Alice Njolke Mafe,

Ali B. M. Ali

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 289, P. 138633 - 138633

Published: Dec. 13, 2024

Language: Английский

Citations

7
Advances in bio-polymer coatings for probiotic microencapsulation: chitosan and beyond for enhanced stability and controlled release DOI Creative Commons
Great Iruoghene Edo, Alice Njolke Mafe,

Nawar. F. Razooqi

et al.

Designed Monomers & Polymers, Journal Year: 2024, Volume and Issue: 28(1), P. 1 - 34

Published: Dec. 31, 2024

This review paper analyzes recent advancements in bio-polymer coatings for probiotic microencapsulation, with a particular emphasis on chitosan and its synergistic combinations other materials. Probiotic microencapsulation is essential protecting probiotics from environmental stresses, enhancing their stability, ensuring effective delivery to the gut. The begins an overview of highlighting significance safeguarding through processing, storage, gastrointestinal transit. Advances chitosan-based encapsulation are explored, including integration bio-polymers such as alginate, gelatin, pectin, well application nanotechnology innovative techniques like spray drying layer-by-layer assembly. Detailed mechanistic insights integrated, illustrating how influences gut microbiota by promoting beneficial bacteria suppressing pathogens, thus role prebiotic or synbiotic. Furthermore, delves into chitosan's immunomodulatory effects, particularly context inflammatory bowel disease (IBD) autoimmune diseases, describing immune signaling pathways influenced linking changes improvements systemic immunity. Recent clinical trials human studies assessing efficacy chitosan-coated presented, alongside discussion practical applications comparison vitro vivo findings highlight real-world relevance. sustainability sources impact addressed, along novel concept gut-brain axis. Finally, emphasizes future research needs, development personalized therapies exploration techniques.

Language: Английский

Citations

5
The Impact of Microbiota on Neurological Disorders: Mechanisms and Therapeutic Implications DOI Open Access
Giuseppe Merra,

Giada La Placa,

Marcello Covino

et al.

OBM Neurobiology, Journal Year: 2025, Volume and Issue: 09(01), P. 1 - 12

Published: Feb. 28, 2025

Interactions in the gut-brain crosstalk have led to development of an entirely new concept: "microbiota-gut-brain axis". Microbiota has gained considerable attention relation disorders a more neurological nature, such as neurodevelopmental and neuropsychiatric illnesses like autism spectrum disorder, anxiety, mood disorders. This review aims summarize recent trends insights into role consequences gut microbiota brain health pediatric Dysbiosis may be associated with increased risk diseases that lead different disruptions conditions, including mental issues. During dysbiosis, neuropsychological stress hormones usually affect oxytocin GABA neurons are significantly reduced. Current studies report major depression, cognitive dysfunction closely dysbiosis. In last few years, handful clinical emerged, illustrating potential for bidirectional relationship interactions humans. Perhaps some most crucial investigations demonstrating overlapping relationships human axis come from trials focusing on modulating noting significant correlates. A field is emerging gene-editing technology could represent tool improve microbial characteristics. approach particularly relevant neurodegenerative brain-gut linked loss species and/or high pathobiont load.

Language: Английский

Citations

0
Exploring human brain development and disease using assembloids DOI
Sih‐Rong Wu, Tomasz J. Nowakowski

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Effect of nutritional supplements on gut microbiome in individuals with neurodevelopmental disorders: a systematic review and narrative synthesis DOI Creative Commons

Elaheh Dehghani,

Keyvan Karimi,

Soheil Arekhi

et al.

BMC Nutrition, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 29, 2025

Neurodevelopmental disorders (NDDs) encompass a range of disruptive conditions with varying prevalence rates and multiple contributing factors. Recent studies have suggested potential connection between NDDs the gut-brain axis. Furthermore, there is evidence indicating that nutritional supplements might an impact on gastrointestinal (GI) behavioral symptoms. This study aimed to explore effects gut microbiota symptoms in individuals NDDs. A systematic search databases such as PubMed, Scopus, Web Science, Embase, APA PsycINFO was conducted, utilizing relevant keywords until February 2025. In addition, for gray literature carried out Google Scholar ProQuest. The risk bias assessed using ROBINS-I tool non-randomized RoB-1 randomized controlled trials. Due heterogeneity studies, Synthesis without Meta-analysis (SWiM) approach employed. overall findings from indicated positive supplementation reducing Gastrointestinal Severity Index (GIS) score alleviating GI Supplementation probiotics vitamins increased good microbiomes (GM) decrease bad (BM) among autism spectrum disorder (ASD). Moreover, Firmicutes Bacteroidetes ratio (F/R ratio) exhibited significant changes after supplementation. Additionally, improvements were observed various assessment scores, including ATEC, ABC, CARS, PGI-2. Nutritional can influence by modulating microbiome, dysbiosis, enhancing barrier integrity. Shifting F/R be considered reason improving influencing neurotransmitter activity neuroinflammation. Targeting axis interventions focus offers promising adjunct therapy management NDD. Registration review protocol. PROSPERO registration no. CRD42023460449.

Language: Английский

Citations

0
High-cellulose diet ameliorates cognitive impairment by modulating gut microbiota and metabolic pathways in mice DOI
Moeka Tanabe, Kazuo Kunisawa, Isao Saito

et al.

Journal of Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Early-Life Antibiotic Exposures: Paving the Pathway for Dysbiosis-Induced Disorders DOI
Ali Attiq

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177298 - 177298

Published: Jan. 1, 2025

Language: Английский

Citations

0
Gut Microbes: Therapeutic Target for Neuropsychiatric Disorders DOI
Keya Mallick, Gopal Khodve,

Ritika Ruwatia

et al.

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 184, P. 27 - 38

Published: Feb. 21, 2025

Language: Английский

Citations

0
The regulatory mechanism of intermittent fasting and probiotics on cognitive function by the microbiota‐gut‐brain axis DOI
Yili Chen, Chi‐Tang Ho, Xin Zhang

et al.

Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(3)

Published: March 1, 2025

Abstract Intermittent fasting (IF) is an eating pattern that promotes health and cognitive improvement through periodic eating. It has been shown to enhance neuroplasticity reduce oxidative stress inflammation. Recent studies have demonstrated probiotic supplementation enhances performance by modulating gut microbiota composition increasing short‐chain fatty acid production, which in turn neurogenesis synaptic plasticity. The microbiota‐gut‐brain axis (MGBA) the communication bridge between brain, influencing function immune, endocrine, nervous systems. combination of probiotics IF may exert complementary effects on function, with enhancing microbial diversity metabolic efficiency, while further modulate barrier integrity neurotransmitter synthesis. This review critically examines interplay via MGBA, identifying key mechanisms potential therapeutic strategies remain underexplored current research.

Language: Английский

Citations

0