Multimorbidity in Severe Mental Illness as Part of the Neurodevelopmental Continuum: Physical Health-Related Endophenotypes of Schizophrenia—A Narrative Review DOI Creative Commons
V. V. Genkel,

Elena Domozhirova,

Е. В. Малинина

и другие.

Brain Sciences, Год журнала: 2024, Номер 14(7), С. 725 - 725

Опубликована: Июль 19, 2024

Background. The majority of deaths in patients with schizophrenia and other severe mental illnesses (SMIs) are caused by natural causes, such as cardiovascular diseases (CVDs). increased risk CVD somatic SMIs cannot be fully explained the contribution traditional factors, behavioral patients’ lifestyle peculiarities, influence antipsychotics. present review has following main objectives: (1) to aggregate evidence that neurodevelopmental disorders basis SMIs; (2) provide a studies have addressed shared genetic architecture SMI disease; (3) propose substantiate consideration independent endophenotypes SMIs, which will make it possible place research within framework concepts “neurodevelopmental continuum gradient” “endophenotype”. Methods. A comprehensive literature search was performed on 1 July 2024. using PubMed Google Scholar databases up June Results. current reveals considerable overlap between susceptibility loci for CVDs. We observed can considered distinct physical health-related endophenotypes. Conclusions. In this narrative review, results recent CVDs summarized. Reframing multisystem disease should contribute activation new SMIs.

Язык: Английский

Tract-based analyses of white matter in schizophrenia, bipolar disorder, aging, and dementia using high spatial and directional resolution diffusion imaging: a pilot study DOI Creative Commons
Daniel Mamah,

ShingShiun Chen,

Joshua S. Shimony

и другие.

Frontiers in Psychiatry, Год журнала: 2024, Номер 15

Опубликована: Фев. 1, 2024

Introduction Structural brain connectivity abnormalities have been associated with several psychiatric disorders. Schizophrenia (SCZ) is a chronic disabling disorder accelerated aging and increased risk of dementia, though findings in the rarely directly compared to those that occur aging. Methods We used an automated approach reconstruct key white matter tracts assessed tract integrity five participant groups. acquired one-hour-long high-directional diffusion MRI data from young control (CON, n =28), bipolar (BPD, =21), SCZ (n =22) participants aged 18-30, healthy elderly (ELD, =15) dementia (DEM, =9) participants. Volume, fractional (FA), radial diffusivity (RD) axial (AD) seven (anterior thalamic radiation, ATR; dorsal ventral cingulum bundle, CBD CBV; corticospinal tract, CST; three superior longitudinal fasciculi: SLF-1, SLF-2 SLF-3) were analyzed TRACULA. Group comparisons metrics performed using multivariate univariate analyses. Clinical relationships recent symptoms BPD Results A MANOVA showed group differences FA (λ=0.5; p=0.0002) RD (λ=0.35; p<0.0001) across tracts, but no significant AD volume. Post-hoc analyses indicated lower higher ELD DEM groups CON, Lower CON did not meet statistical significance. In participants, negative correlation was found between psychosis severity SLF-1 (r= -0.45; p=0.035), -0.49; p=0.02) SLF-3 -0.44; p=0.042). Discussion Our results indicate impaired populations consistent myelin damage. Impaired most prominent patients advanced illness.

Язык: Английский

Процитировано

5
Shared Molecular Signature in Alzheimer's Disease and Schizophrenia: A Systematic Review of the Reelin Signaling Pathway DOI Creative Commons

Ana Isabel Valderrama-Mantilla,

Celia Martín-Cuevas, Ana Gómez-Garrido

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2025, Номер 169, С. 106032 - 106032

Опубликована: Янв. 31, 2025

Язык: Английский

Процитировано

0
Recent Advances in Schizophrenia Genomics and Emerging Clinical Implications DOI
Tim B. Bigdeli, Philip D. Harvey

Psychiatric Clinics of North America, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Age-Related Changes in Sleep and Its Implications for Cognitive Decline in Aging Persons With Schizophrenia: A Critical Review DOI Creative Commons
Bengi Baran, Ellen Lee

Schizophrenia Bulletin, Год журнала: 2024, Номер unknown

Опубликована: Май 7, 2024

Abstract Background and Hypothesis Cognitive impairment is a core feature of schizophrenia that worsens with aging interferes quality life. Recent work identifies sleep as an actionable target to alleviate cognitive deficits. Cardinal non-rapid eye movement (NREM) oscillations such spindles slow are critical for cognition. People living (PLWS) their first-degree relatives have specific reduction in abnormality temporal coordination predict impaired memory consolidation. While NREM oscillatory activity reduced typical aging, it not known how further disruption these contributes decline older PLWS. Another understudied risk factor deficits among PLWS obstructive apnea (OSA) which may contribute decline. Study Design We conducted narrative review examine the published literature on OSA, Results Spindles propagated via thalamocortical feedback loops, this circuitry shows abnormal hyperconnectivity revealed by structural functional MRI studies. severity OSA increase age, particularly vulnerable OSA-related because often underdiagnosed undertreated, adds damage generates oscillations. Conclusions highlight need study PWLS propose identifying treating will provide avenue potentially mitigate prevent

Язык: Английский

Процитировано

2
Is Schizophrenia a Disorder of Accelerated Whole-System Aging? DOI
Peter Kochunov, Hong Liu

Biological Psychiatry, Год журнала: 2024, Номер 95(11), С. 988 - 989

Опубликована: Май 13, 2024

Язык: Английский

Процитировано

2
Understanding the role of sleep disturbance on cognitive decline in aging persons with schizophrenia: A critical review DOI Open Access
Bengi Baran, Ellen Lee

Опубликована: Янв. 4, 2024

Cognitive impairment is a core feature of schizophrenia that worsens with aging and interferes quality, functioning independence in everyday life. Recent work identifies sleep as an actionable target to alleviate cognitive deficits. Cardinal non-rapid eye movement (NREM) oscillations such spindles slow are critical for cognition. People living (PLWS) their first-degree relatives have specific reduction abnormality temporal coordination predicts impaired memory consolidation. Spindles propagated via thalamocortical feedback loops, this circuitry shows abnormal hyperconnectivity revealed by structural functional MRI studies. Although line research well-defined NREM associated deficits, it not known how changes PLWS. One understudied risk factor deficits among older PLWS untreated obstructive apnea (OSA), disorder where airway collapse results intermittent hypoxia and, when untreated, can contribute decline. While the severity OSA increases age, particularly vulnerable OSA-related because often underdiagnosed undertreated, adds further damage generates oscillations. We highlight need study PWLS propose identifying treating will provide avenue potentially mitigate prevent

Язык: Английский

Процитировано

1
Epigenetics and aging: relevance for sleep medicine DOI
Rene Cortese

Current Opinion in Pulmonary Medicine, Год журнала: 2024, Номер unknown

Опубликована: Июль 31, 2024

Sleep disorders encompass a wide range of conditions with substantial individual variability. Epigenetics, the study heritable changes beyond DNA sequence, offers promising avenue for personalized medicine in this field.

Язык: Английский

Процитировано

1
“Aging Amplifies Challenges”: A Descriptive Phenomenological Exploration of the Lived Experiences and Needs of Elderly Individuals With Schizophrenia DOI Open Access
Linghui Zhang, Yubin Chen, Hong Yu

и другие.

Nursing and Health Sciences, Год журнала: 2024, Номер 26(4)

Опубликована: Окт. 9, 2024

Older adults diagnosed with schizophrenia face unique public health challenges, specific treatment needs, complex care demands, accelerated aging, and increased susceptibility to issues. This phenomenological study explored the existential realities needs of older schizophrenia. Fifteen participants, a mean age 69.47 (SD ± 9.47) years, ranging from 62 79 years old hailing rural regions, participated in study. Four main themes eight sub-themes emerge: compounding burden (challenges symptom management, comorbidities); abyss life filled emptiness (loss mental pillars, living agony); on margins society (the vicious cycle social self-isolation, unattainable welfare); glimmer light darkness (support systems, self-adjustment). The calls for healthcare professionals improve follow-up efficiency, strengthen engagement, understand patients' conditions enforce existing welfare policies mentally ill patients, enhance their quality life.

Язык: Английский

Процитировано

1
Brain Age Gap as a Predictor of Early Treatment Response and Functional Outcomes in First-Episode Schizophrenia: A Longitudinal Study: L'écart d'âge cérébral comme prédicteur de la réponse en début de traitement et des résultats fonctionnels dans un premier épisode de schizophrénie : une étude longitudinale DOI Creative Commons
Lejia Fan, Zhenmei Zhang, Xiaoqian Ma

и другие.

The Canadian Journal of Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 10, 2024

Accelerated brain aging, i.e., the age-related structural changes in appearing earlier than expected from one's chronological age, is a feature that now well established schizophrenia. Often interpreted as of progressive pathophysiological process typifies schizophrenia, its prognostic relevance still unclear. We investigate role response to antipsychotic treatment first-episode

Язык: Английский

Процитировано

1
Epigenetic signatures in children and adolescents at familial high risk: linking early-life environmental exposures to psychopathology DOI Creative Commons
Àlex G. Segura,

Irene Martínez-Serrano,

Elena de la Serna

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Авг. 10, 2024

Abstract Background This study investigates the relationship between environmental risk factors and severe mental disorders using genome-wide methylation data. Methylation profile scores (MPS) epigenetic clocks were utilized to analyze alterations in a cohort comprising 211 individuals aged 6–17 years. Participants included offspring of schizophrenia (n = 30) bipolar disorder 82) patients, community control group 99). The aimed assess differences MPS indicative intrauterine stress aging across familial groups, their associations with cognition, prodromal psychotic symptoms, global functioning through statistical models. Results Individuals at high demonstrated significant associated pre-pregnancy maternal overweight/obesity, pre-eclampsia, early preterm birth higher weight (p.adj ≤ 0.001) as well decelerated Horvath Hannum 0.005). Among more positive general symptoms correlated related BMI overweight/obesity 0.008) accelerated all examined 0.012). Conclusions These findings underscore potential analysis quantify persistent effects events influence on onset particularly high-risk populations. Further research is essential elucidate underlying biological mechanisms during critical stages neurodevelopment.

Язык: Английский

Процитировано

0