Random Mutagenesis as a Promising Tool for Microalgal Strain Improvement towards Industrial Production

Marine Drugs, Год журнала: 2022, Номер 20(7), С. 440 - 440

Опубликована: Июнь 30, 2022

Microalgae have become a promising novel and sustainable feedstock for meeting the rising demand food feed. However, microalgae-based products are currently hindered by high production costs. One major reason this is that commonly cultivated wildtype strains do not possess robustness productivity required successful industrial production. Several strain improvement technologies been developed towards creating more stress tolerant productive strains. While classical methods of forward genetics extensively used to determine gene function randomly generated mutants, reverse has explored generate specific mutations target phenotypes. Site-directed mutagenesis can be accomplished employing different editing tools, which enable generation tailor-made genotypes. Nevertheless, strategies promoting selection mutants avoid introduction foreign genetic material. In paper, we review microalgal approaches their applications, with primary focus on random mutagenesis. Current challenges hampering improvement, selection, commercialization will discussed. The combination these high-throughput technologies, such as fluorescence-activated cell sorting, tools select most also

Язык: Английский

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Microalgae biofuels: illuminating the path to a sustainable future amidst challenges and opportunities

Biotechnology for Biofuels and Bioproducts, Год журнала: 2024, Номер 17(1)

Опубликована: Янв. 23, 2024

Abstract The development of microalgal biofuels is significant importance in advancing the energy transition, alleviating food pressure, preserving natural environment, and addressing climate change. Numerous countries regions across globe have conducted extensive research strategic planning on bioenergy, investing funds manpower into this field. However, microalgae biofuel industry has faced a downturn due to constraints high costs. In past decade, with new strains, technologies, equipment, feasibility large-scale production should be re-evaluated. Here, we gathered results from decade regarding production, providing insights opportunities challenges by perspectives selection, modification, cultivation. review, suggest that highly adaptable are preferred choice for especially strains can utilize concentrations inorganic carbon sources possess stress resistance. use omics technologies genetic editing greatly enhanced lipid accumulation microalgae. associated risks constrained outdoor Therefore, relatively controllable cultivation method photobioreactors (PBRs) made it mainstream approach production. Moreover, adjusting performance parameters PBRs also enhance future, given relentless escalation demand sustainable sources, deemed pivotal constituent national planning, particularly case China. advancement synthetic biology helps reduce genetically modified (GM) enhances economic viability their Graphical

Язык: Английский

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Integrated culture and harvest systems for improved microalgal biomass production and wastewater treatment

Bioresource Technology, Год журнала: 2023, Номер 376, С. 128941 - 128941

Опубликована: Март 21, 2023

Язык: Английский

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Applications of Microalgae in Foods, Pharma and Feeds and Their Use as Fertilizers and Biostimulants: Legislation and Regulatory Aspects for Consideration

Foods, Год журнала: 2023, Номер 12(20), С. 3878 - 3878

Опубликована: Окт. 23, 2023

Microalgae are a rich resource of lipids, proteins, carbohydrates and pigments with nutritional health benefits. They increasingly find use as ingredients in functional foods feeds well cosmetics agricultural products including biostimulants. One their distinct advantages is ability to grow on wastewaters other waste streams, they considered an environmentally friendly cheap method recover nutrients remove pollutants from the environment. However, there limits concerning applications if grown certain streams. Within, we collate overview existing algal current market scenarios for microalgal along relevant legislative requirements Europe United States. Microalgal compounds interest extraction processing methodologies summarized, benefits caveats microalgae cultivated various streams discussed.

Язык: Английский

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Recent advances in enhancing the production of long chain omega-3 fatty acids in microalgae

Critical Reviews in Food Science and Nutrition, Год журнала: 2023, Номер 64(29), С. 10564 - 10582

Опубликована: Июнь 26, 2023

Omega-3 fatty acids have gained attention due to numerous health benefits. Eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) are long chain omega-3 produced from precursor ALA (α-linolenic acid) in humans but their rate of biosynthesis is low, therefore, these must be present diet or should taken as supplements. The commercial sources limited vegetable oils marine sources. rising concern about vegan source, fish aquaculture conservation heavy metal contamination has led the search for alternative source. Microalgae importance production high-value EPA DHA can thus serve a sustainable promising source acids. Although bottleneck lies optimization enhanced that involves strategies

Язык: Английский

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Emerging prospects of microbial production of omega fatty acids: Recent updates

Bioresource Technology, Год журнала: 2022, Номер 360, С. 127534 - 127534

Опубликована: Июнь 28, 2022

Язык: Английский

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Highly Valuable Fish Oil: Formation Process, Enrichment, Subsequent Utilization, and Storage of Eicosapentaenoic Acid Ethyl Esters

Molecules, Год журнала: 2023, Номер 28(2), С. 672 - 672

Опубликована: Янв. 9, 2023

In recent years, as the demand for precision nutrition is continuously increasing, scientific studies have shown that high-purity eicosapentaenoic acid ethyl ester (EPA-EE) functions more efficiently than mixed omega-3 polyunsaturated fatty preparations in diseases such hyperlipidemia, heart disease, major depression, and disease; therefore, market EPA-EE growing by day. this paper, we attempt to review from a whole-manufacturing-chain perspective. First, extraction, refining, ethanolysis processes (fish oil ethanol undergo transesterification) of are described, emphasizing potential green substitute technologies. Then, method EPA enrichment thoroughly detailed, pros cons different methods compared, current developments monomer production techniques addressed. Finally, summary advanced strategies dealing with low oxidative stability bioavailability presented. conclusion, understanding entire process will enable us govern each step macro perspective accomplish best use cost-effective environmentally friendly way.

Язык: Английский

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Microalgae stress sensing through oxidative phosphorylation drives bioenergy potential: deciphering mechanisms and future opportunities

Journal of environmental chemical engineering, Год журнала: 2024, Номер 12(6), С. 114266 - 114266

Опубликована: Сен. 26, 2024

Язык: Английский

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A comprehensive review on microbial lipid production from wastes: research updates and tendencies

Environmental Science and Pollution Research, Год журнала: 2023, Номер 30(33), С. 79654 - 79675

Опубликована: Июнь 16, 2023

Язык: Английский

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Hydroponic effluent recycling and resource recovery using heterotrophic Chlorella microalgae: Advancing a circular bioeconomy

Journal of Water Process Engineering, Год журнала: 2024, Номер 67, С. 106176 - 106176

Опубликована: Сен. 16, 2024

Язык: Английский

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