Biosensors and Bioelectronics, Год журнала: 2025, Номер unknown, С. 117395 - 117395
Опубликована: Март 1, 2025
Язык: Английский
Sensors and Actuators B Chemical, Год журнала: 2022, Номер 359, С. 131604 - 131604
Опубликована: Фев. 19, 2022
Язык: Английский
Процитировано
74
Chemical Science, Год журнала: 2023, Номер 14(23), С. 6149 - 6206
Опубликована: Янв. 1, 2023
The disastrous spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has induced public healthcare issues and weakened the global economy significantly. Although SARS-CoV-2 infection is not as fatal initial outbreak, many infected victims suffer from long COVID. Therefore, rapid large-scale testing critical in managing patients alleviating its transmission. Herein, we review recent advances techniques to detect SARS-CoV-2. sensing principles are detailed together with their application domains analytical performances. In addition, advantages limits each method discussed analyzed. Besides molecular diagnostics antigen antibody tests, also neutralizing antibodies emerging variants. Further, characteristics mutational locations different variants epidemiological features summarized. Finally, challenges possible strategies prospected develop new assays meet diagnostic needs. Thus, this comprehensive systematic detection technologies may provide insightful guidance direction for developing tools diagnosis analysis support effective long-term pandemic management control.
Язык: Английский
Процитировано
39
Health and Technology, Год журнала: 2023, Номер 13(2), С. 273 - 284
Опубликована: Янв. 6, 2023
Abstract This scoping review compiled information concerning digital health technologies (DHTs) evolution to support primary care (PHC) during COVID-19 and lessons for the future of PHC. The identified literature was published peak years (2019–2021), retrieved from PubMed, Scopus, Google Scholar, as well hand searched on internet. Predefined inclusion criteria were used, thematic analysis applied, reporting followed PRISMA Scoping Reviews. A total 46 studies included in final synthesis (40 articles, one book, two book chapters, working paper, technical reports). These scrutinized various aspects DHTs, entailing 19 types DHTs with 20 areas use that can be compressed into five bigger PHC functions: general service delivery (teleconsultations, e-diagnosis, e-prescription, etc.); behavior promotion literacy (e.g., combating vaccine hesitancy); surveillance functions; vaccination drugs; enhancing system decision-making proper follow-up ongoing interventions COVID-19. have potential solve some problems plagued us even prior Therefore, this study uses a forward-looking viewpoint further stimulate evidence-based DHT, making it more inclusive, educative, satisfying people’s needs, both under normal conditions outbreaks. More research narrowed questions is needed, particular emphasis quality assurance (standards tools, infrastructure, platforms), financial perspectives (payment services adoption incentives).
Язык: Английский
Процитировано
37
Nature Communications, Год журнала: 2023, Номер 14(1)
Опубликована: Июль 10, 2023
Abstract Real-time surveillance of airborne SARS-CoV-2 virus is a technological gap that has eluded the scientific community since beginning COVID-19 pandemic. Offline air sampling techniques for detection suffer from longer turnaround times and require skilled labor. Here, we present proof-of-concept pathogen Air Quality (pAQ) monitor real-time (5 min time resolution) direct aerosols. The system synergistically integrates high flow (~1000 lpm) wet cyclone sampler nanobody-based ultrasensitive micro-immunoelectrode biosensor. showed comparable or better performance than commercially available samplers. Laboratory experiments demonstrate device sensitivity 77–83% limit 7-35 viral RNA copies/m 3 air. Our pAQ suited point-of-need variants in indoor environments can be adapted multiplexed other respiratory pathogens interest. Widespread adoption such technology could assist public health officials with implementing rapid disease control measures.
Язык: Английский
Процитировано
32
Analytica Chimica Acta, Год журнала: 2022, Номер 1230, С. 340389 - 340389
Опубликована: Сен. 14, 2022
Язык: Английский
Процитировано
39
Chemical Society Reviews, Год журнала: 2023, Номер 52(24), С. 8531 - 8579
Опубликована: Янв. 1, 2023
The framework for on-site airborne pathogen detection and transmission risk mitigation.
Язык: Английский
Процитировано
19
Science Advances, Год журнала: 2025, Номер 11(2)
Опубликована: Янв. 10, 2025
Measuring virus in biofluids is complicated by confounding biomolecules coisolated with viral nucleic acids. To address this, we developed an affinity-based microfluidic device for specific capture of intact severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Our approach used engineered angiotensin-converting enzyme to from plasma and other complex biofluids. leverages a staggered herringbone pattern, nanoparticle surface coating, processing conditions achieve detection as few 3 copies per milliliter. We further validated our assay on 103 plasma, 36 saliva, 29 stool samples collected unique patients COVID-19, showing SARS-CoV-2 72% samples. Longitudinal monitoring the revealed device’s capacity ultrasensitive active infections over time. technology can be adapted target viruses using relevant cell entry molecules affinity capture. This versatility underscores potential widespread application load disease management.
Язык: Английский
Процитировано
1
Coordination Chemistry Reviews, Год журнала: 2025, Номер 534, С. 216578 - 216578
Опубликована: Март 4, 2025
Язык: Английский
Процитировано
1
Analytical Chemistry, Год журнала: 2022, Номер 94(33), С. 11591 - 11599
Опубликована: Авг. 10, 2022
The COVID-19 pandemic has led to a global crisis with devastating effects on public healthcare and the economy. Sensitive detection of SARS-CoV-2 is key diagnose control its spread. spike (S) protein an abundant viral transmembrane suitable target for selective recognition SARS-CoV-2. Here, we report that bovine serum albumin prescreening, specific phage peptide targeting S1 was biopanned pIII display library. identified #2 expressing (amino acid sequence: NFWISPKLAFAL) shows high affinity dissociation constant 3.45 ± 0.58 nM. Furthermore, good specificity binding site at N-terminal domain subunit through hydrogen bond network hydrophobic interaction, supported by molecular docking. Then, sandwiched phage-based enzyme-linked chemiluminescence immunoassay (ELCLIA) established using as bifunctional probe capable antigen signal amplification. After optimizing conditions, proposed ELCLIA exhibited sensitivity, low 78 pg/mL could be detected. This method can applied detect 60 transducing units (TU)/mL pseudovirus in 50% saliva. Therefore, peptides have prospects powerful biological probes biomedical applications.
Язык: Английский
Процитировано
29
Biosensors, Год журнала: 2022, Номер 12(9), С. 762 - 762
Опубликована: Сен. 16, 2022
Nanomechanical sensors have gained significant attention as powerful tools for detecting, distinguishing, and identifying target analytes, especially odors that are composed of a complex mixture gaseous molecules. their arrays promising platform artificial olfaction in combination with data processing technologies, including machine learning techniques. This paper reviews the background nanomechanical sensors, conventional cantilever-type sensors. Then, we focus on one optimized structures static mode operation, Membrane-type Surface stress Sensor (MSS), discuss recent advances MSS applications towards olfaction.
Язык: Английский
Процитировано
27