Biosensors and Bioelectronics, Год журнала: 2024, Номер 249, С. 116021 - 116021
Опубликована: Янв. 9, 2024
Язык: Английский
Процитировано
21A SERS aptasensor based on a flexible substrate for interference-free detection of carbendazim in apple
Food Chemistry, Год журнала: 2023, Номер 431, С. 137120 - 137120
Опубликована: Авг. 9, 2023
Язык: Английский
Процитировано
43Raman spectroscopy for viral diagnostics
Biophysical Reviews, Год журнала: 2023, Номер 15(2), С. 199 - 221
Опубликована: Апрель 1, 2023
Abstract Raman spectroscopy offers the potential for fingerprinting biological molecules at ultra-low concentration and therefore has detection of viruses. Here we review various techniques employed investigation Different are discussed including conventional spectroscopy, surface-enhanced tweezer, tip-enhanced Spectroscopy, coherent anti-Stokes scattering. Surface-enhanced scattering can play an essential role in viral by multiplexing nanotechnology, microfluidics, machine learning ensuring spectral reproducibility efficient workflow sample processing detection. The application these to diagnose SARS-CoV-2 virus is also reviewed. Graphical abstract
Язык: Английский
Процитировано
30Current developments of SELEX technologies and prospects in the aptamer selection with clinical applications
Journal of Genetic Engineering and Biotechnology, Год журнала: 2024, Номер 22(3), С. 100400 - 100400
Опубликована: Июль 26, 2024
Aptamers are single-stranded oligonucleotide sequences capable of binding to specific ligands with high affinity. In this manner, they like antibodies but have advantages such as lower manufacturing costs, immunogenicity, fewer batch-to-batch differences, a longer shelf life, tolerance different molecular milieus, and greater number potential targets. Due their special features, been used in drug delivery, biosensor technology, therapy, diagnostics. The methodology that allowed its production was the "Systematic Evolution Ligands by Exponential enrichment" (SELEX). Unfortunately, traditional protocol is time-consuming laborious. Therefore, numerous variants considerable optimization steps developed, nonetheless, there still challenges achieving real applications clinical field. Among them, control vivo activities, fast renal filtration, degradation nucleases toxicity testing. This review focuses on current technologies based SELEX, critical factors for successful aptamer selection, upcoming biomedical biotechnological applications.
Язык: Английский
Процитировано
10Intelligent quantitative recognition of SARS-CoV-2 using machine learning-based ratiometric fluorescent paper sensors of metal-organic framework Al3+/Au NCs@ZIF-90
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159933 - 159933
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1Aptamer-based biosensors for wastewater surveillance of influenza virus, SARS-CoV-2, and norovirus: A comprehensive review
Water Research, Год журнала: 2025, Номер unknown, С. 123484 - 123484
Опубликована: Март 1, 2025
Wastewater-based epidemiological (WBE) surveillance has emerged as a crucial tool for monitoring infectious diseases within communities. However, its broader application is frequently constrained by the high costs, labor-intensive processes, and extended timeframes required sample collection, transportation, processing. Aptamer-based biosensors offer promising alternative, leveraging specific binding properties of aptamers to biomolecules on-site rapid quantification disease biomarkers in wastewater. This review systematically evaluates recent advancements aptamer-based detection key pathogens, including influenza viruses, SARS-CoV-2, norovirus, wastewater matrices. The discussion encompasses technical stability reliability signal transmission associated with these biosensors, well current challenges faced real-world implementation. Noteworthy progress been made development WBE, achieving limits low femtomolar (fM) levels buffer linear dynamic ranges extending up five orders magnitude viruses such SARS-CoV-2. Despite this progress, considerable hurdles remain be addressed before technologies can effectively deployed practical settings, especially complex environments. Key factors affecting performance include matrix interference, environmental variability, diminished both viral targets aptamer-target interactions not only highlights but also outlines potential avenues future research aimed at enhancing functionality applicability ultimately contributing more effective public health strategies.
Язык: Английский
Процитировано
1Recent Advances in DNA Nanotechnology-Enabled Biosensors for Virus Detection
Biosensors, Год журнала: 2023, Номер 13(8), С. 822 - 822
Опубликована: Авг. 15, 2023
Virus-related infectious diseases are serious threats to humans, which makes virus detection of great importance. Traditional virus-detection methods usually suffer from low sensitivity and specificity, time-consuming, have a high cost, etc. Recently, DNA biosensors based on nanotechnology shown potential in detection. nanotechnology, specifically tiles aptamers, has achieved atomic precision nanostructure construction. Exploiting the programmable nature nanostructures, researchers developed nanobiosensors that outperform traditional methods. This paper reviews history it briefly describes Baltimore classification virology. Moreover, advance by using is discussed detail compared with Finally, challenges faced summarized, perspective future development also provided.
Язык: Английский
Процитировано
20Recent advances of surface enhanced Raman spectroscopy (SERS) in optical biosensing
TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер unknown, С. 117990 - 117990
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
9Aptamers and Nanobodies as New Bioprobes for SARS-CoV-2 Diagnostic and Therapeutic System Applications
Biosensors, Год журнала: 2024, Номер 14(3), С. 146 - 146
Опубликована: Март 15, 2024
The global challenges posed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic have underscored critical importance of innovative and efficient control systems for addressing future pandemics. most effective way to is rapidly suppress spread virus through early detection using a rapid, accurate, easy-to-use diagnostic platform. In biosensors that use bioprobes, binding affinity molecular recognition elements (MREs) primary factor determining dynamic range sensing Furthermore, sensitivity relies mainly on bioprobe quality with sufficient functionality. This comprehensive review investigates aptamers nanobodies recently developed as advanced MREs SARS-CoV-2 therapeutic applications. These bioprobes might be integrated into organic bioelectronic materials devices, promising enhanced specificity. offers valuable insights advancing biosensing technologies infectious disease diagnosis treatment new bioprobes.
Язык: Английский
Процитировано
6Hydrogen-bonded organic framework-based core–shell structures via a pore confinement control strategy for high performance SERS sensing
Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 156559 - 156559
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
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