Ferroptosis: principles and significance in health and disease

Journal of Hematology & Oncology, Год журнала: 2024, Номер 17(1)

Опубликована: Июнь 6, 2024

Abstract Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid peroxidation, is governed molecular networks involving diverse molecules and organelles. Since its recognition as a non-apoptotic pathway in 2012, ferroptosis has emerged crucial mechanism numerous physiological pathological contexts, leading to significant therapeutic advancements across wide range diseases. This review summarizes the fundamental mechanisms regulatory pathways underlying ferroptosis, including both GPX4-dependent -independent antioxidant mechanisms. Additionally, we examine involvement various conditions, cancer, neurodegenerative diseases, sepsis, ischemia–reperfusion injury, autoimmune disorders, metabolic disorders. Specifically, explore role response chemotherapy, radiotherapy, immunotherapy, nanotherapy, targeted therapy. Furthermore, discuss pharmacological strategies for modulating potential biomarkers monitoring this process. Lastly, elucidate interplay between other forms regulated death. Such insights hold promise advancing our understanding context human health disease.

Язык: Английский

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Versatile organic fluorescent probes for visualizing the dynamics of lipid droplets

Coordination Chemistry Reviews, Год журнала: 2024, Номер 522, С. 216181 - 216181

Опубликована: Сен. 5, 2024

Язык: Английский

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Simultaneous detection of peroxynitrite and viscosity in diabetes by a dual response fluorescent probe

Sensors and Actuators B Chemical, Год журнала: 2024, Номер 406, С. 135432 - 135432

Опубликована: Фев. 2, 2024

Язык: Английский

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Near-Infrared Fluorescent Probe Reveals Elevated Mitochondrial Viscosity during Acute Alcoholic Liver Injury

Analytical Chemistry, Год журнала: 2024, Номер 96(37), С. 14860 - 14866

Опубликована: Сен. 4, 2024

Acute alcoholic liver injury (AALI) has become an important cause of disease worldwide, and there is urgent need to develop noninvasive sensitive methods detect evaluate AALI. We report herein three novel but readily available mitochondrial targeting fluorescence probes (

Язык: Английский

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Recent progress in small molecule fluorescent probes for imaging and diagnosis of non-alcoholic fatty liver disease

Coordination Chemistry Reviews, Год журнала: 2024, Номер 513, С. 215864 - 215864

Опубликована: Май 7, 2024

Язык: Английский

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Constructing Dual-State Emissive Fluorophores via Boc Protection and Discovering a High-Fidelity Imaging Probe for Lipid Droplets

Analytical Chemistry, Год журнала: 2024, Номер 96(17), С. 6724 - 6729

Опубликована: Апрель 18, 2024

Dual-state emissive (DSE) materials exhibit fluorescence in both solid and solution states have become an emerging material the fields of science sensing recent years. However, due to lack effective universal preparation methods, DSE materials, especially those with long emission wavelengths, are still scarce. Developing method for constructing such molecules is urgently needed. In this study, we constructed three (NRP-Boc, DCIP-Boc, DCMP-Boc) far-red near-infrared by simply modifying traditional aggregation-caused quenching (ACQ) fluorophores tert-butyloxycarbonyl (Boc) groups. Density functional theory (DFT) calculations crystal data revealed reasons bright these solid, demonstrating that Boc protection a simple strategy molecules. We also found potential target visualize lipid droplets (LDs). Among them, DCIP-Boc shows advantages large Stokes shift, wavelength, low background, good photostability cells, providing powerful new molecular tool property high-fidelity imaging LDs.

Язык: Английский

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A Membrane‐Targeting Aggregation‐Induced Emission Probe for Monitoring Lipid Droplet Dynamics in Ischemia/Reperfusion‐Induced Cardiomyocyte Ferroptosis

Advanced Science, Год журнала: 2024, Номер 11(26)

Опубликована: Май 2, 2024

Myocardial ischemia/reperfusion injury (MIRI) is the leading cause of irreversible myocardial damage. A pivotal pathogenic factor (I/R)-induced cardiomyocyte ferroptosis, marked by iron overload and lipid peroxidation. However, impact droplet (LD) changes on I/R-induced ferroptosis unclear. In this study, an aggregation-induced emission probe, TPABTBP developed that used for imaging dynamic in LD during ferroptosis. exhibits excellent LD-specificity, superior capability monitoring lipophagy, remarkable photostability. Molecular dynamics (MD) simulation super-resolution fluorescence demonstrate specifically localized to phospholipid monolayer membrane LDs. Imaging LDs cardiomyocytes tissue model mice with MIRI reveals accumulation level increase early reperfusion stage (0-9 h) but decrease late (>24 via lipophagy. The inhibition breakdown significantly reduces peroxidation cardiomyocytes. Furthermore, it demonstrated chloroquine (CQ), FDA-approved autophagy modulator, can inhibit thereby attenuating mice. This study describes ischemia suggests a potential therapeutic target intervention.

Язык: Английский

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Near-infrared polarity fluorescent probe for wash-free imaging lipid droplets and the application in the diagnosis of non-alcoholic fatty liver tissue

Microchemical Journal, Год журнала: 2024, Номер 205, С. 111236 - 111236

Опубликована: Июль 17, 2024

Язык: Английский

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Near-infrared lipid droplets polarity fluorescent probe for early diagnosis of nonalcoholic fatty liver disease

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2024, Номер 318, С. 124479 - 124479

Опубликована: Май 19, 2024

Язык: Английский

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Multifunctional lipid droplet probes for observing the polarity change of ferroptosis, inflammation, fatty liver and evaluating the efficacy of drugs

Analytica Chimica Acta, Год журнала: 2024, Номер 1312, С. 342747 - 342747

Опубликована: Май 20, 2024

Язык: Английский

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