Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases
Qingdong Bao,
Xiaoting Zhang,
Zhankun Hao
и другие.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Авг. 13, 2024
Abstract
The
eye,
a
complex
organ
isolated
from
the
systemic
circulation,
presents
significant
drug
delivery
challenges
owing
to
its
protective
mechanisms,
such
as
blood-retinal
barrier
and
corneal
impermeability.
Conventional
administration
methods
often
fail
sustain
therapeutic
levels
may
compromise
patient
safety
compliance.
Polysaccharide-based
microneedles
(PSMNs)
have
emerged
transformative
solution
for
ophthalmic
delivery.
However,
comprehensive
review
of
PSMNs
in
ophthalmology
has
not
been
published
date.
In
this
review,
we
critically
examine
synergy
between
polysaccharide
chemistry
microneedle
technology
enhancing
ocular
We
provide
thorough
analysis
PSMNs,
summarizing
design
principles,
fabrication
processes,
addressed
during
fabrication,
including
improving
comfort
also
describe
recent
advances
performance
various
both
research
clinical
scenarios.
Finally,
current
regulatory
frameworks
market
barriers
that
are
relevant
commercial
advancement
final
perspective
on
area.
Язык: Английский
Borophene based quasi planar nanocluster for ethanol, isobutanol, and acetone sensing: A first principle study
Journal of Molecular Graphics and Modelling,
Год журнала:
2025,
Номер
136, С. 108951 - 108951
Опубликована: Янв. 9, 2025
Язык: Английский
Large gold nanoparticle release assay for attomolar detection of miRNA related to myelodysplastic neoplasms
Talanta,
Год журнала:
2025,
Номер
unknown, С. 128037 - 128037
Опубликована: Март 1, 2025
Язык: Английский
Engineering sampling microneedles for biomolecules sensing
Chemical Engineering Journal,
Год журнала:
2024,
Номер
unknown, С. 156130 - 156130
Опубликована: Сен. 1, 2024
Язык: Английский
Impact of microelectrode geometry and surface finish on enzymatic biosensor performance
Electrochimica Acta,
Год журнала:
2024,
Номер
unknown, С. 145270 - 145270
Опубликована: Окт. 1, 2024
Язык: Английский
The viability of Parkinson's monitoring by microneedle patches: A theory-guided critical analysis
Applied Physics Letters,
Год журнала:
2024,
Номер
125(17)
Опубликована: Окт. 21, 2024
Diagnosis
and
treatment
of
Parkinson's
disease
(PD)
are
challenging
because
levodopa
(LD)-dependent
therapies
primarily
rely
on
symptom
observation
management.
More
sophisticated
methods
for
LD
tracking,
namely,
high-performance
liquid
chromatography,
UV,
mass
spectrometry,
etc.,
expensive
slow.
As
a
potential
alternative,
wearable
microneedle
(MN)-based
patches,
coated
with
nanodendrites
(NDs),
offer
promising,
continuous,
minimally
invasive
monitoring.
Laboratory-based
platforms
show
high
sensitivity
sub-micrometer
detection,
but
predictive
design
framework
does
not
exist.
Here,
we
report
an
analytical
I=f(LD)
ND-on-MNs,
quantifying
the
amperometric
response
I
ND-on-MN
platform
in
terms
geometric,
catalytic
sensor
parameters,
environmental
conditions.
We
find
counter-intuitive
results
that
factors
(e.g.,
low
medium
diffusivity
fluctuation),
rather
than
details
geometry,
dictate
limits.
A
scaled
against
parameters
provides
key
insights:
(a)
maximum
enhancement
factor
this
is
around
12%,
emphasizing
importance
optimizing
parameters;
(b)
Design
strategies
focusing
high-density
sensing
sites
efficient
LD-ND
binding
most
effective
solutions
improved
detection;
(c)
Increasing
geometric
dimensions
recommended
due
to
patient
discomfort.
The
model,
validated
experimental
data,
highlights
limitations
technology
tracking
suggests
directions
MN-based
devices
PD
management,
including
enhancing
selectivity.
Язык: Английский