The viability of Parkinson's monitoring by microneedle patches: A theory-guided critical analysis DOI
Marco Fratus, Muhammad A. Alam

Applied Physics Letters, Journal Year: 2024, Volume and Issue: 125(17)

Published: Oct. 21, 2024

Diagnosis and treatment of Parkinson's disease (PD) are challenging because levodopa (LD)-dependent therapies primarily rely on symptom observation management. More sophisticated methods for LD tracking, namely, high-performance liquid chromatography, UV, mass spectrometry, etc., expensive slow. As a potential alternative, wearable microneedle (MN)-based patches, coated with nanodendrites (NDs), offer promising, continuous, minimally invasive monitoring. Laboratory-based platforms show high sensitivity sub-micrometer detection, but predictive design framework does not exist. Here, we report an analytical I=f(LD) ND-on-MNs, quantifying the amperometric response I ND-on-MN platform in terms geometric, catalytic sensor parameters, environmental conditions. We find counter-intuitive results that factors (e.g., low medium diffusivity fluctuation), rather than details geometry, dictate limits. A scaled against parameters provides key insights: (a) maximum enhancement factor this is around 12%, emphasizing importance optimizing parameters; (b) Design strategies focusing high-density sensing sites efficient LD-ND binding most effective solutions improved detection; (c) Increasing geometric dimensions recommended due to patient discomfort. The model, validated experimental data, highlights limitations technology tracking suggests directions MN-based devices PD management, including enhancing selectivity.

Language: Английский

Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases DOI Creative Commons

Qingdong Bao,

Xiaoting Zhang,

Zhankun Hao

et al.

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: Aug. 13, 2024

Abstract The eye, a complex organ isolated from the systemic circulation, presents significant drug delivery challenges owing to its protective mechanisms, such as blood-retinal barrier and corneal impermeability. Conventional administration methods often fail sustain therapeutic levels may compromise patient safety compliance. Polysaccharide-based microneedles (PSMNs) have emerged transformative solution for ophthalmic delivery. However, comprehensive review of PSMNs in ophthalmology has not been published date. In this review, we critically examine synergy between polysaccharide chemistry microneedle technology enhancing ocular We provide thorough analysis PSMNs, summarizing design principles, fabrication processes, addressed during fabrication, including improving comfort also describe recent advances performance various both research clinical scenarios. Finally, current regulatory frameworks market barriers that are relevant commercial advancement final perspective on area.

Language: Английский

Citations

8
Borophene based quasi planar nanocluster for ethanol, isobutanol, and acetone sensing: A first principle study DOI

Nima Ajalli,

Forough Rezaie, Saeedeh Kamalinahad

et al.

Journal of Molecular Graphics and Modelling, Journal Year: 2025, Volume and Issue: 136, P. 108951 - 108951

Published: Jan. 9, 2025

Language: Английский

Citations

0
Large gold nanoparticle release assay for attomolar detection of miRNA related to myelodysplastic neoplasms DOI
Giusy Finocchiaro, Tomáš Špringer, Zdeněk Krejčík

et al.

Talanta, Journal Year: 2025, Volume and Issue: unknown, P. 128037 - 128037

Published: March 1, 2025

Language: Английский

Citations

0
Engineering sampling microneedles for biomolecules sensing DOI
Yun Cheng, Xi Luan,

Jiawu Weng

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156130 - 156130

Published: Sept. 1, 2024

Language: Английский

Citations

3
Impact of microelectrode geometry and surface finish on enzymatic biosensor performance DOI
Jian Xu, Marco Fratus, Ankit Shah

et al.

Electrochimica Acta, Journal Year: 2024, Volume and Issue: unknown, P. 145270 - 145270

Published: Oct. 1, 2024

Language: Английский

Citations

0
The viability of Parkinson's monitoring by microneedle patches: A theory-guided critical analysis DOI
Marco Fratus, Muhammad A. Alam

Applied Physics Letters, Journal Year: 2024, Volume and Issue: 125(17)

Published: Oct. 21, 2024

Diagnosis and treatment of Parkinson's disease (PD) are challenging because levodopa (LD)-dependent therapies primarily rely on symptom observation management. More sophisticated methods for LD tracking, namely, high-performance liquid chromatography, UV, mass spectrometry, etc., expensive slow. As a potential alternative, wearable microneedle (MN)-based patches, coated with nanodendrites (NDs), offer promising, continuous, minimally invasive monitoring. Laboratory-based platforms show high sensitivity sub-micrometer detection, but predictive design framework does not exist. Here, we report an analytical I=f(LD) ND-on-MNs, quantifying the amperometric response I ND-on-MN platform in terms geometric, catalytic sensor parameters, environmental conditions. We find counter-intuitive results that factors (e.g., low medium diffusivity fluctuation), rather than details geometry, dictate limits. A scaled against parameters provides key insights: (a) maximum enhancement factor this is around 12%, emphasizing importance optimizing parameters; (b) Design strategies focusing high-density sensing sites efficient LD-ND binding most effective solutions improved detection; (c) Increasing geometric dimensions recommended due to patient discomfort. The model, validated experimental data, highlights limitations technology tracking suggests directions MN-based devices PD management, including enhancing selectivity.

Language: Английский

Citations

0