Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices

Frontiers in Bioengineering and Biotechnology, Год журнала: 2023, Номер 11

Опубликована: Апрель 27, 2023

Microfluidics is an interdisciplinary field that encompasses both science and engineering, which aims to design fabricate devices capable of manipulating extremely low volumes fluids on a microscale level. The central objective microfluidics provide high precision accuracy while using minimal reagents equipment. benefits this approach include greater control over experimental conditions, faster analysis, improved reproducibility. Microfluidic devices, also known as labs-on-a-chip (LOCs), have emerged potential instruments for optimizing operations decreasing costs in various industries, including pharmaceutical, medical, food, cosmetics. However, the price conventional prototypes LOCs generated clean room facilities, has increased demand inexpensive alternatives. Polymers, paper, hydrogels are some materials can be utilized create microfluidic covered article. In addition, we highlighted different manufacturing techniques, such soft lithography, laser plotting, 3D printing, suitable creating LOCs. selection fabrication techniques will depend specific requirements applications each individual LOC. This article comprehensive overview numerous alternatives development low-cost service industries pharmaceuticals, chemicals, biomedicine.

Язык: Английский

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Combining 3D Printing and Microfluidic Techniques: A Powerful Synergy for Nanomedicine

Pharmaceuticals, Год журнала: 2023, Номер 16(1), С. 69 - 69

Опубликована: Янв. 1, 2023

Nanomedicine has grown tremendously in recent years as a responsive strategy to find novel therapies for treating challenging pathological conditions. As result, there is an urgent need develop formulations capable of providing adequate therapeutic treatment while overcoming the limitations traditional protocols. Lately, microfluidic technology (MF) and additive manufacturing (AM) have both acquired popularity, bringing numerous benefits wide range life science applications. There been drawbacks MF AM distinct techniques, with case studies showing how careful optimization operational parameters enables them overcome existing limitations. Therefore, focus this review was highlight potential synergy between AM, emphasizing significant that collaboration could entail. The combination techniques ensures full customization MF-based systems remaining cost-effective less time-consuming compared classical approaches. Furthermore, enable highly sustainable procedures suitable industrial scale-out, leading one most promising innovations near future.

Язык: Английский

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Polydimethylsiloxane Surface Modification of Microfluidic Devices for Blood Plasma Separation

Polymers, Год журнала: 2024, Номер 16(10), С. 1416 - 1416

Опубликована: Май 16, 2024

Over the last decade, researchers have developed a variety of new analytical and clinical diagnostic devices. These devices are predominantly based on microfluidic technologies, where biological samples can be processed manipulated for collection detection important biomolecules. Polydimethylsiloxane (PDMS) is most commonly used material in fabrication these However, it has hydrophobic nature (contact angle with water 110°), leading to poor wetting behavior issues related mixing fluids, difficulties obtaining uniform coatings, reduced efficiency processes such as plasma separation molecule (protein adsorption). This work aimed consider aspects PDMS applications, surface modification methods. Therefore, we studied characterized two methods hydrophilic surfaces: by bulk mixture immersion method. To modify properties, three different surfactants were both (Pluronic

Язык: Английский

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Microfluidics enhanced biosensor technology for advancing food safety monitoring

Trends in Food Science & Technology, Год журнала: 2024, Номер 149, С. 104556 - 104556

Опубликована: Май 24, 2024

Язык: Английский

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Effects of bulk and wall chemical reactions on hydrodynamic dispersion of a solute in a couple stress fluid

Physical Review Fluids, Год журнала: 2025, Номер 10(1)

Опубликована: Янв. 29, 2025

Язык: Английский

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