Biomedical Journal,
Год журнала:
2023,
Номер
46(5), С. 100663 - 100663
Опубликована: Сен. 28, 2023
This
issue
of
the
Biomedical
Journal
puts
an
emphasis
on
inflammasome
subunits,
NLR
protein
family,
and
role
they
play
in
immunity.
CIITA
is
presented
as
promising
tool
for
augmenting
tumor
immunogenicity.
Several
articles
look
into
involvement
NLRP3
inflammatory
bowel
disease
changes
gut
microbiome,
blood
glucose
management,
sterile
inflammation,
NLRP3's
contribution
to
development
hepatic
encephalopathy.
Furthermore,
a
review
concerning
small
cell
neuroendocrine
carcinoma
cervix
presented,
insights
are
provided
association
knee
pain
patellar
malalignment,
connection
between
hypoxia
sleep
apnea
case
liver
injury
elucidated.
Additional
illuminate
challenge
predicting
influenza
infections;
show
how
ctDNA
may
serve
predictor
survival
outcome
ovarian
carcinoma;
lastly
soft
tissue
after
bimaxillary
rotational
surgery
assessed.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Янв. 5, 2024
Abstract
Inflammasomes
are
large
protein
complexes
that
play
a
major
role
in
sensing
inflammatory
signals
and
triggering
the
innate
immune
response.
Each
inflammasome
complex
has
three
components:
an
upstream
sensor
molecule
is
connected
to
downstream
effector
such
as
caspase-1
through
adapter
ASC.
Inflammasome
formation
typically
occurs
response
infectious
agents
or
cellular
damage.
The
active
then
triggers
activation,
followed
by
secretion
of
pro-inflammatory
cytokines
pyroptotic
cell
death.
Aberrant
activation
activity
contribute
development
diabetes,
cancer,
several
cardiovascular
neurodegenerative
disorders.
As
result,
recent
research
increasingly
focused
on
investigating
mechanisms
regulate
assembly
well
potential
targeting
inflammasomes
treat
various
diseases.
Multiple
clinical
trials
currently
underway
evaluate
therapeutic
distinct
inflammasome-targeting
therapies.
Therefore,
understanding
how
different
disease
pathology
may
have
significant
implications
for
developing
novel
strategies.
In
this
article,
we
provide
summary
biological
pathological
roles
health
disease.
We
also
highlight
key
evidence
suggests
could
be
strategy
new
disease-modifying
therapies
effective
conditions.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(19), С. 14511 - 14511
Опубликована: Сен. 25, 2023
Nucleotide-binding
and
oligomerization
domain
(NOD)-like
receptors
(NLRs)
are
intracellular
proteins
with
a
central
role
in
innate
adaptive
immunity.
As
member
of
pattern
recognition
(PRRs),
NLRs
sense
specific
pathogen-associated
molecular
patterns,
trigger
numerous
signaling
pathways
lead
to
the
secretion
various
cytokines.
In
recent
years,
cumulative
studies
have
revealed
significant
impacts
gastrointestinal
(GI)
inflammatory
diseases
cancers.
Deciphering
mechanism
NLR
may
provide
new
opportunities
for
development
therapeutic
strategies
related
GI
This
review
presents
structures
NLRs,
summarizes
advances
regarding
cancers
describes
comprehensive
based
on
this
pathway.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
175, С. 116679 - 116679
Опубликована: Май 3, 2024
The
NOD-like
receptor
protein
3
(NLRP3)
inflammasome
is
a
complex
that
regulates
innate
immune
responses
by
activating
caspase-1
and
the
inflammatory
cytokines
IL-1β
IL-18.
Numerous
studies
have
highlighted
its
crucial
role
in
pathogenesis
development
of
bowel
disease,
rheumatoid
arthritis,
systemic
lupus
erythematosus,
autoimmune
thyroid
diseases,
other
diseases.
Therefore,
investigating
underlying
mechanisms
NLRP3
disease
targeted
drug
therapies
holds
clinical
significance.
This
review
summarizes
structure,
assembly,
activation
inflammasome,
focusing
on
involvement
various
also
identifies
where
mechanism
within
same
appears
contradictory,
as
well
differences
NLRP3-related
gene
polymorphisms
among
different
ethnic
groups.
Additionally,
latest
therapeutic
advances
targeting
for
diseases
are
outlined,
novel
perspectives
discussed.
Conclusively,
this
provides
consolidated
source
information
may
guide
future
research
efforts
potential
to
positively
impact
patient
outcomes.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 22, 2024
Pyroptosis
is
an
innate
immune
response
triggered
by
the
activation
of
inflammasomes
various
influencing
factors,
characterized
cell
destruction.
It
impacts
system
and
cancer
immunotherapy.
In
recent
years,
roles
pyroptosis
in
intestinal
inflammation
have
been
continuously
confirmed.
This
article
reviews
latest
progress
mechanisms,
new
discoveries
inflammasomes,
mutual
regulation
between
their
applications
diseases.
Additionally,
potential
synergistic
treatment
mechanisms
diseases
with
are
summarized,
challenges
future
directions
discussed,
providing
ideas
for
therapy.
Abstract
The
gut
microbiota
plays
a
critical
role
in
maintaining
human
health,
influencing
wide
range
of
physiological
processes,
including
immune
regulation,
metabolism,
and
neurological
function.
Recent
studies
have
shown
that
imbalances
composition
can
contribute
to
the
onset
progression
various
diseases,
such
as
metabolic
disorders
(e.g.,
obesity
diabetes)
neurodegenerative
conditions
Alzheimer's
Parkinson's).
These
are
often
accompanied
by
chronic
inflammation
dysregulated
responses,
which
closely
linked
specific
forms
cell
death,
pyroptosis
ferroptosis.
Pathogenic
bacteria
trigger
these
death
pathways
through
toxin
release,
while
probiotics
been
found
mitigate
effects
modulating
responses.
Despite
insights,
precise
mechanisms
influences
diseases
remain
insufficiently
understood.
This
review
consolidates
recent
findings
on
impact
immune‐mediated
inflammation‐associated
conditions.
It
also
identifies
gaps
current
research
explores
potential
advanced
technologies,
organ‐on‐chip
models
microbiome–gut–organ
axis,
for
deepening
our
understanding.
Emerging
tools,
single‐bacterium
omics
spatial
metabolomics,
discussed
their
promise
elucidating
microbiota's
disease
development.
Current Medicinal Chemistry,
Год журнала:
2024,
Номер
31(15), С. 2021 - 2051
Опубликована: Фев. 4, 2024
Abstract:
Inflammasomes
are
multimeric
protein
complexes
that
can
detect
various
physiological
stimuli
and
danger
signals.
As
a
result,
they
perform
crucial
function
in
the
innate
immune
response.
The
NLRP3
inflammasome,
as
vital
constituent
of
inflammasome
family,
is
significant
defending
against
pathogen
invasion
preserving
cellhomeostasis.
dysregulation
connected
to
pathological
conditions,
including
inflammatory
diseases,
cancer,
cardiovascular
neurodegenerative
diseases.
This
profile
makes
an
applicable
target
for
treating
related
therefore,
there
rising
inhibitors
disclosed
therapy.
Herein,
we
summarized
updated
advances
structure,
function,
inflammasome.
Moreover,
aimed
provide
overview
existing
products
future
directions
drug
research
development.
International Journal of Medical Sciences,
Год журнала:
2024,
Номер
21(8), С. 1385 - 1398
Опубликована: Янв. 1, 2024
Inflammatory
bowel
disease
(IBD)
is
a
chronic
inflammatory
intestinal
disease,
characterized
by
dysregulated
immune
response.
HDAC3
reported
to
be
an
epigenetic
brake
in
inflammation,
playing
critical
roles
macrophages.
However,
its
role
IBD
unclear.
In
our
study,
we
found
was
upregulated
CX3CR1-positive
cells
the
mucosa
from
mice.
Conditional
knockout
(cKO)
of
Hdac3
CX3CR1
positive
attenuated
severity
Dextran
Sulfate
Sodium
(DSS)-induced
colitis.
addition,
inhibition
with
RGFP966
could
also
alleviate
DSS-induced
tissue
injury
and
inflammation
IBD.
The
RNA
sequencing
results
revealed
that
cKO
restrained
upregulation
genes
pathways
cytokine-cytokine
receptor
interaction,
complement
coagulation
cascades,
chemokine
signaling,
extracellular
matrix
interaction.
We
identified
Guanylate-Binding
Protein
5
(GBP5)
transcriptionally
regulated
monocytes
sequencing.
Inhibition
resulted
decreased
transcriptional
activity
interferon-gamma-induced
expression
GBP5
cells,
such
as
macrophages
microglia.
Overexpression
reporter.
Lastly,
conditional
(Hdac3
mKO)
conclusion,
ameliorate
response
colitis
regulating
GBP5-NLRP3
axis,
identifying
new
therapeutic
avenue
for
treatment
