Tissue and Cell, Год журнала: 2024, Номер 93, С. 102672 - 102672
Опубликована: Дек. 10, 2024
Язык: Английский
Cells, Год журнала: 2024, Номер 13(17), С. 1437 - 1437
Опубликована: Авг. 27, 2024
The gut microbiota plays an essential role in maintaining immune homeostasis and influencing the landscape within tumor microenvironment. This review aims to elucidate interactions between dynamics, with a focus on colorectal cancer (CRC). spans foundational concepts of immuno-microbial interplay, factors microbiome composition, evidence linking immunotherapy outcomes. Gut modulates anti-cancer immunity through several mechanisms, including enhancement surveillance modulation inflammatory responses. Specific microbial species their metabolic byproducts can significantly influence efficacy immunotherapies. Furthermore, diversity correlates clinical outcomes CRC, suggesting potential as valuable biomarker for predicting response immunotherapy. Conclusions: Understanding relationship responses offers novel therapeutic strategies development. not only influences natural history treatment CRC but also serves critical modulator activity. Further exploration into microbiome's could enhance effectiveness existing treatments guide development new modalities.
Язык: Английский
Процитировано
10
MedComm, Год журнала: 2024, Номер 5(12)
Опубликована: Ноя. 20, 2024
Abstract The gut microbiota plays a critical role in maintaining human health, influencing wide range of physiological processes, including immune regulation, metabolism, and neurological function. Recent studies have shown that imbalances composition can contribute to the onset progression various diseases, such as metabolic disorders (e.g., obesity diabetes) neurodegenerative conditions Alzheimer's Parkinson's). These are often accompanied by chronic inflammation dysregulated responses, which closely linked specific forms cell death, pyroptosis ferroptosis. Pathogenic bacteria trigger these death pathways through toxin release, while probiotics been found mitigate effects modulating responses. Despite insights, precise mechanisms influences diseases remain insufficiently understood. This review consolidates recent findings on impact immune‐mediated inflammation‐associated conditions. It also identifies gaps current research explores potential advanced technologies, organ‐on‐chip models microbiome–gut–organ axis, for deepening our understanding. Emerging tools, single‐bacterium omics spatial metabolomics, discussed their promise elucidating microbiota's disease development.
Язык: Английский
Процитировано
7
Brazilian Journal of Otorhinolaryngology, Год журнала: 2025, Номер 91(3), С. 101566 - 101566
Опубликована: Фев. 13, 2025
Язык: Английский
Процитировано
0
Diabetes Metabolic Syndrome and Obesity, Год журнала: 2025, Номер Volume 18, С. 453 - 464
Опубликована: Фев. 1, 2025
This study investigates the potential of plasma Gasdermin D (GSDMD) as a novel biomarker for early diagnosis and monitoring type 2 diabetes mellitus. We conducted comparative analysis clinical indicators among newly diagnosed patients, those with prediabetes, healthy controls, finding significantly elevated GSDMD levels in group (P < 0.05). Correlation analyses revealed that were positively associated inflammatory markers insulin resistance, while negatively correlating HOMA-β 0.001). Logistic regression identified GSDMD, IL-6, CRP independent risk factors The area under ROC curve was 0.988, indicating superior diagnostic capability compared to traditional like (0.902) IL-6 (0.857). With threshold 17.67 pg/mL, exhibited sensitivity 93.9% specificity 98.0%. These findings suggest not only reflects metabolic abnormalities but also holds promise therapeutic target mitigate responses improve resistance. Further large-scale studies are warranted validate its utility enhance applications.
Язык: Английский
Процитировано
0
Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 3349 - 3360
Опубликована: Март 1, 2025
Pyroptosis is a unique form of programmed cell death characterized by intense inflammation. It involves the activation Gasdermin proteins, which membrane pores, leading to rapid rupture and release inflammatory molecules. Unlike other types death, pyroptosis has distinct mechanisms plays complex role in chronic intestinal diseases, including bowel disease, fibrosis, infectious enteritis, colorectal cancer. This review comprehensively examines how influences disease development progression while exploring therapeutic potential targeting pyroptosis-related pathways. Moreover, interplay between gut microbiota summarized, highlighting its critical pathogenesis disorders. A deeper understanding these diseases may provide valuable insights for future research contribute innovative strategies gastroenterology.
Язык: Английский
Процитировано
0
Frontiers in Bioscience-Landmark, Год журнала: 2024, Номер 29(7)
Опубликована: Июль 19, 2024
Inflammatory bowel disease (IBD) is a chronic and recurrent inflammatory of the intestinal tract. The complex pathophysiological mechanisms IBD include genetic susceptibility, environmental factors, abnormal immune response gut microbiota. Gut microbiota forms metabolic organ that contributes to human health by performing various physiological functions. development closely linked imbalance In patients, this mainly characterized an increased abundance pro-inflammatory microorganisms, specifically enteropathogenic bacteria. Pyroptosis form programmed cell death can be initiated microbial infection or host factors. It occurs mostly after intracellular with bacteria pathogens. Other than death, its primary effect release mediators trigger in host. important component innate immunity protect against risk factors via response. However, excessive activation cause disease. Previous studies have indicated relationship between pyroptosis. Some activate host’s system clear infected cells. This inhibits proliferation inducing pyroptosis restoring balance initial damage integrity barrier are crucial elicit onset favor progression. review summarizes research on role several common through their induction A better understanding interactions should lead identification new targets treatment options for IBD.
Язык: Английский
Процитировано
2
Journal of Ethnopharmacology, Год журнала: 2024, Номер unknown, С. 118943 - 118943
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
2
World Journal of Gastrointestinal Oncology, Год журнала: 2024, Номер 16(8), С. 3410 - 3427
Опубликована: Авг. 7, 2024
Pyroptosis is a type of programmed cell death mediated by gasdermines (GSDMs). The N-terminal domain GSDMs forms pores in the plasma membrane, causing membrane rupture and release contents, leading to an inflammatory response mediating pyrodeath. plays important role diseases malignant tumors. With further study pyroptosis, increasing number studies have shown that pyroptosis pathway can regulate tumor microenvironment antitumor immunity colorectal cancer closely related occurrence, development, treatment prognosis cancer. This review aimed explore molecular mechanism (CRC) provide ideas for clinical diagnosis CRC.
Язык: Английский
Процитировано
0
Food & Function, Год журнала: 2024, Номер 15(19), С. 9863 - 9879
Опубликована: Янв. 1, 2024
Non-alcoholic fatty liver disease (NAFLD) poses a significant health threat due to its potential progression fibrosis, cirrhosis, and even cancer. Without proper management, NAFLD can lead severe complications significantly impact overall longevity. This study explores the anti-steatosis effects of Nankun Mountain Mao tea (MT) on hepatic lipid accumulation using both in vitro vivo models. In experiments reveal that MT reduces hepatocytes counteracts steatosis induced by palmitic acid oleic acid. investigations high-fat diet (HFD)-fed high-fat, fructose, cholesterol (HFFC)-fed mice demonstrate administration alleviates reducing accumulation, enhancing function, mitigating inflammation. Transcriptomic analyses unveil molecular mechanisms underlying metabolism It turns out inhibits de novo synthesis NF-κB pathway against NAFLD. Furthermore, target prediction analysis identifies bioactive components group (BCG) within may contribute properties. Validation studies primary confirm effectiveness these diminishing inflammation, suggesting their role therapeutic efficacy
Язык: Английский
Процитировано
0
Tissue and Cell, Год журнала: 2024, Номер 93, С. 102672 - 102672
Опубликована: Дек. 10, 2024
Язык: Английский
Процитировано
0