Materials Today Communications, Год журнала: 2025, Номер unknown, С. 112094 - 112094
Опубликована: Март 1, 2025
Язык: Английский
Biomimetics, Год журнала: 2025, Номер 10(1), С. 28 - 28
Опубликована: Янв. 4, 2025
The development of biocompatible hydrogels for 3D bioprinting is essential creating functional tissue models and advancing preclinical drug testing. This study investigates the formulation, printability, mechanical properties, biocompatibility a novel Alg-Gel hydrogel blend (alginate gelatin) use in extrusion-based bioprinting. A range compositions were evaluated their rheological behavior, including shear-thinning storage modulus, compressive which are crucial maintaining structural integrity during printing supporting cell viability. printability assessment 7% alginate-8% gelatin demonstrated that 27T tapered needle achieved highest normalized Printability Index (POInormalized = 1), offering narrowest strand width (0.56 ± 0.02 mm) accuracy (97.2%) at lowest pressure (30 psi). In contrast, 30R needle, with smallest inner diameter (0.152 (80 psi), resulted widest (0.70 0.01 (88.8%), resulting POInormalized 0.274. 30T 27R needles moderate performance, values 0.758 0.558, respectively. optimized alginate 8% favorable strength, compatibility MDA-MB-213 breast cancer cells, exhibiting high proliferation rates minimal cytotoxicity over 2-week culture period. formulation offers balanced approach, providing sufficient viscosity precision while minimizing shear stress to preserve health. work lays groundwork future advancements bioprinted models, contributing more effective tools screening personalized medicine.
Язык: Английский
Процитировано
1
Results in Engineering, Год журнала: 2025, Номер unknown, С. 104017 - 104017
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
JACS Au, Год журнала: 2025, Номер 5(2), С. 411 - 425
Опубликована: Янв. 22, 2025
The increasing human population is leading to growing consumption of energy sources which requires development in devices. modern iterations these devices fail offer sustainable and environmentally friendly answers since they require costly equipment produce a lot waste. Three-dimensional (3D) printing has spurred incredible innovation over the years variety fields clearly an attractive option because technology can create unique geometric items quickly, cheaply, with little Conducting polymers (CPs) are significant family functional materials that have garnered interest research community their high conductivity, outstanding sustainability, economic significance. They extensive number applications involving supercapacitors, power sources, electrochromic gadgets, electrostatic components, conducting pastes, sensors, biological thanks special physical electrical attributes, ease synthesis, appropriate frameworks for attachment. use three-dimensional become popular as exact way enhance prepared networks. Rapid technological advancements reproducing patterns building structures enable automated deposition intricate structures. Different composites been created using oxides metals carbon improve efficiency CPs. Such actively investigated exceptional producers low-power electronic techniques, by range applications, verified surface area, remarkable electrochemical behavior. hybridization such produced equipment, gathering energy, protective storage facilities. A few possible uses CPs sensors discussed this perspective. We also provide overview key strategies scientific industrial eye on potential improvements future.
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140245 - 140245
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Polymers for Advanced Technologies, Год журнала: 2025, Номер 36(4)
Опубликована: Март 31, 2025
ABSTRACT 3D printing technology has shown significant promise in bone tissue engineering, enabling the fabrication of intricate structures while controlling porosity and mechanical properties. Integrating into provides a vital benefit by allowing implants to precisely match an individual's anatomy, improving outcomes reducing risk rejection. Additionally, this approach supports inclusion bioactive substances growth factors enhance regeneration. This study examines most recent advances for production, stressing their potential regenerative medicine personalized healthcare. It also addresses challenges associated with current processes engineering explores possible avenues future research development. Furthermore, article investigates how biocompatibility bioactivity materials used facilitate effective Likewise, it evaluates scaffold design architecture can promote cell attachment, proliferation, differentiation, thereby encouraging successful restoration. In conclusion, thorough assessment offers critical insights progress obstacles proposes directions inquiry exciting field. By leveraging these advancements, clinicians researchers pioneer new therapies that address defects improve outcomes.
Язык: Английский
Процитировано
1
Next Materials, Год журнала: 2025, Номер 8, С. 100647 - 100647
Опубликована: Апрель 16, 2025
Язык: Английский
Процитировано
1
Polymers, Год журнала: 2023, Номер 15(20), С. 4122 - 4122
Опубликована: Окт. 17, 2023
Three-dimensional printing technology has fundamentally revolutionized the product development processes in several industries. enables creation of tailored prostheses and other medical equipment, anatomical models for surgical planning training, even innovative means directly giving drugs to patients. Polymers their composites have found broad usage healthcare business due many beneficial properties. As a result, application 3D area transformed design manufacturing devices prosthetics. become attractive materials this industry because unique mechanical, thermal, electrical, optical qualities. This review article presents comprehensive analysis current state-of-the-art applications polymer its field using technology. It covers latest research developments patient-specific devices, prostheses, training. The also discusses use drug delivery systems (DDS) tissue engineering. Various techniques, such as stereolithography, fused deposition modeling (FDM), selective laser sintering (SLS), are reviewed, along with benefits drawbacks. Legal regulatory issues related addressed. concludes an outlook on future potential field. findings indicate that enormous revolutionize manufacture leading improved patient outcomes better services.
Язык: Английский
Процитировано
21
Applied Materials Today, Год журнала: 2024, Номер 38, С. 102231 - 102231
Опубликована: Май 14, 2024
Язык: Английский
Процитировано
9
Advanced Materials, Год журнала: 2024, Номер 36(27)
Опубликована: Апрель 19, 2024
Abstract Advancing biofabrication toward manufacturing living constructs with well‐defined architectures and increasingly biologically relevant cell densities is highly desired to mimic the biofunctionality of native human tissues. The formulation tissue‐like, cell‐dense inks for remains, however, challenging at various levels bioprinting process. Promising advances have been made this goal, achieving relatively high that surpass those found in conventional platforms, pushing current boundaries closer tissue‐like densities. On focus, herein overarching challenges bioprocessing cell‐rich into clinically grade engineered tissues are discussed, as well most recent ink formulations their processing technologies highlighted. Additionally, an overview foreseen developments field provided critically discussed.
Язык: Английский
Процитировано
7
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Ноя. 21, 2024
Tissue biofabrication mimicking organ-specific architecture and function requires physiologically-relevant cell densities. Bioprinting using spheroids can achieve this, but is limited due to the lack of practical, scalable techniques. This study presents HITS-Bio (High-throughput Integrated Fabrication System for Bioprinting), a multiarray bioprinting technique rapidly positioning multiple simultaneously digitally-controlled nozzle array (DCNA). achieves an unprecedented speed, ten times faster compared existing techniques while maintaining high viability ( > 90%). The utility was exemplified in applications, including intraoperative with microRNA transfected human adipose-derived stem calvarial bone regeneration ~ 30 mm3) rat model achieving near-complete defect closure (bone coverage area 91% 3 weeks ~96% 6 weeks). Additionally, successful fabrication cartilage constructs (1 cm3) containing ~600 chondrogenic highlights its high-throughput efficiency (under 40 min per construct) potential repairing volumetric defects. HITS-Bio, platform, assembles mimic native tissue architecture. Its application shows repair rats cartilage.
Язык: Английский
Процитировано
7