Additive manufacturing,
Год журнала:
2024,
Номер
92, С. 104397 - 104397
Опубликована: Июль 1, 2024
The
predominant
technique
for
producing
3D-printed
structures
of
nanocellulose
involves
freeze-drying
despite
its
drawbacks
in
terms
energy
consumption
and
carbon
footprint.
This
study
explores
the
less-energy-intensive
drying
approach
by
leveraging
valorization
forest
residual
streams.
We
utilized
wood
flour
Kraft
lignin
as
fillers
to
facilitate
room-temperature
nanocellulose-based
3D
printed
structures.
Various
ink
formulations,
integrating
cellulose
nanofibers,
flour,
lignin,
were
tested
direct
writing
(DIW).
formulations
exhibited
shear-thinning
behavior
distinct
yield
stress
with
rising
levels,
ensuring
effective
flow
during
DIW.
Consequently,
multilayered
objects
high
shape
fidelity
precise
dimensions.
Lignin
prevented
structural
collapse
upon
drying.
A
reduced
shrinkage
was
observed
addition
freeze
room
temperature
Moreover,
dried
samples
denser
demonstrated
significantly
higher
resistance
applied
compressive
force,
surpassing
those
reported
cellulose-based
composites
existing
literature.
Remarkably,
trade-off
effects
are
highlighted
efficient
stress-distributing
micro-scale
sliding,
enabling
better
strength.
Along
it
further
increases
thermal
stability.
However,
hinders
hierarchical
porous
structure,
main
ion
transportation
channels,
reducing
double-layer
capacitance
carbonized
Overall,
results
underscore
potential
all-biobased
DIW
practical
applications,
highlighting
their
enhanced
mechanical
properties
integrity
via
more
sustainable
method.
Polymers,
Год журнала:
2023,
Номер
15(20), С. 4122 - 4122
Опубликована: Окт. 17, 2023
Three-dimensional
printing
technology
has
fundamentally
revolutionized
the
product
development
processes
in
several
industries.
enables
creation
of
tailored
prostheses
and
other
medical
equipment,
anatomical
models
for
surgical
planning
training,
even
innovative
means
directly
giving
drugs
to
patients.
Polymers
their
composites
have
found
broad
usage
healthcare
business
due
many
beneficial
properties.
As
a
result,
application
3D
area
transformed
design
manufacturing
devices
prosthetics.
become
attractive
materials
this
industry
because
unique
mechanical,
thermal,
electrical,
optical
qualities.
This
review
article
presents
comprehensive
analysis
current
state-of-the-art
applications
polymer
its
field
using
technology.
It
covers
latest
research
developments
patient-specific
devices,
prostheses,
training.
The
also
discusses
use
drug
delivery
systems
(DDS)
tissue
engineering.
Various
techniques,
such
as
stereolithography,
fused
deposition
modeling
(FDM),
selective
laser
sintering
(SLS),
are
reviewed,
along
with
benefits
drawbacks.
Legal
regulatory
issues
related
addressed.
concludes
an
outlook
on
future
potential
field.
findings
indicate
that
enormous
revolutionize
manufacture
leading
improved
patient
outcomes
better
services.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Ноя. 21, 2024
Tissue
biofabrication
mimicking
organ-specific
architecture
and
function
requires
physiologically-relevant
cell
densities.
Bioprinting
using
spheroids
can
achieve
this,
but
is
limited
due
to
the
lack
of
practical,
scalable
techniques.
This
study
presents
HITS-Bio
(High-throughput
Integrated
Fabrication
System
for
Bioprinting),
a
multiarray
bioprinting
technique
rapidly
positioning
multiple
simultaneously
digitally-controlled
nozzle
array
(DCNA).
achieves
an
unprecedented
speed,
ten
times
faster
compared
existing
techniques
while
maintaining
high
viability
(
>
90%).
The
utility
was
exemplified
in
applications,
including
intraoperative
with
microRNA
transfected
human
adipose-derived
stem
calvarial
bone
regeneration
~
30
mm3)
rat
model
achieving
near-complete
defect
closure
(bone
coverage
area
91%
3
weeks
~96%
6
weeks).
Additionally,
successful
fabrication
cartilage
constructs
(1
cm3)
containing
~600
chondrogenic
highlights
its
high-throughput
efficiency
(under
40
min
per
construct)
potential
repairing
volumetric
defects.
HITS-Bio,
platform,
assembles
mimic
native
tissue
architecture.
Its
application
shows
repair
rats
cartilage.
Advanced Materials,
Год журнала:
2024,
Номер
36(27)
Опубликована: Апрель 19, 2024
Abstract
Advancing
biofabrication
toward
manufacturing
living
constructs
with
well‐defined
architectures
and
increasingly
biologically
relevant
cell
densities
is
highly
desired
to
mimic
the
biofunctionality
of
native
human
tissues.
The
formulation
tissue‐like,
cell‐dense
inks
for
remains,
however,
challenging
at
various
levels
bioprinting
process.
Promising
advances
have
been
made
this
goal,
achieving
relatively
high
that
surpass
those
found
in
conventional
platforms,
pushing
current
boundaries
closer
tissue‐like
densities.
On
focus,
herein
overarching
challenges
bioprocessing
cell‐rich
into
clinically
grade
engineered
tissues
are
discussed,
as
well
most
recent
ink
formulations
their
processing
technologies
highlighted.
Additionally,
an
overview
foreseen
developments
field
provided
critically
discussed.
Biomimetics,
Год журнала:
2025,
Номер
10(1), С. 28 - 28
Опубликована: Янв. 4, 2025
The
development
of
biocompatible
hydrogels
for
3D
bioprinting
is
essential
creating
functional
tissue
models
and
advancing
preclinical
drug
testing.
This
study
investigates
the
formulation,
printability,
mechanical
properties,
biocompatibility
a
novel
Alg-Gel
hydrogel
blend
(alginate
gelatin)
use
in
extrusion-based
bioprinting.
A
range
compositions
were
evaluated
their
rheological
behavior,
including
shear-thinning
storage
modulus,
compressive
which
are
crucial
maintaining
structural
integrity
during
printing
supporting
cell
viability.
printability
assessment
7%
alginate-8%
gelatin
demonstrated
that
27T
tapered
needle
achieved
highest
normalized
Printability
Index
(POInormalized
=
1),
offering
narrowest
strand
width
(0.56
±
0.02
mm)
accuracy
(97.2%)
at
lowest
pressure
(30
psi).
In
contrast,
30R
needle,
with
smallest
inner
diameter
(0.152
(80
psi),
resulted
widest
(0.70
0.01
(88.8%),
resulting
POInormalized
0.274.
30T
27R
needles
moderate
performance,
values
0.758
0.558,
respectively.
optimized
alginate
8%
favorable
strength,
compatibility
MDA-MB-213
breast
cancer
cells,
exhibiting
high
proliferation
rates
minimal
cytotoxicity
over
2-week
culture
period.
formulation
offers
balanced
approach,
providing
sufficient
viscosity
precision
while
minimizing
shear
stress
to
preserve
health.
work
lays
groundwork
future
advancements
bioprinted
models,
contributing
more
effective
tools
screening
personalized
medicine.
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 17, 2025
The
cartilage
possesses
limited
regenerative
capacity,
necessitating
advanced
approaches
for
its
repair.
This
study
introduces
a
bioink
designed
tissue
engineering
(TE)
by
incorporating
ionically
cross-linkable
alginate
into
the
photo-cross-linkable
MuMA
bioink,
resulting
in
double
cross-linked
interpenetrating
network
(IPN)
hydrogel.
Additionally,
hyaluronic
acid
(HA),
natural
component
of
and
synovial
fluid,
was
added
to
enhance
scaffold's
properties.
HA
has
been
demonstrated
improve
lubrication,
regulate
inflammation,
promote
cell
proliferation,
support
extracellular
matrix
(ECM)
deposition
regeneration,
making
it
valuable
TE.
Comprehensive
experiments
were
conducted
assess
morphology,
swelling,
degradation,
mechanical
rheological
properties,
printability,
biocompatibility.
Results
indicated
that
scaffolds
comprising
MuMA,
alginate,
exhibited
compressive
moduli
comparable
native
cartilage,
unlike
single
variants.
cross-linking
also
influenced
water
uptake,
porosity,
contributing
scaffold
durability
stability
chondrocyte
support.
Biocompatibility
tests
with
C28/I2
cells
cell-supportive
chondrogenic
potential
bioink.
establishes
mucin
as
versatile
material
specialized
applications.
JACS Au,
Год журнала:
2025,
Номер
5(2), С. 411 - 425
Опубликована: Янв. 22, 2025
The
increasing
human
population
is
leading
to
growing
consumption
of
energy
sources
which
requires
development
in
devices.
modern
iterations
these
devices
fail
offer
sustainable
and
environmentally
friendly
answers
since
they
require
costly
equipment
produce
a
lot
waste.
Three-dimensional
(3D)
printing
has
spurred
incredible
innovation
over
the
years
variety
fields
clearly
an
attractive
option
because
technology
can
create
unique
geometric
items
quickly,
cheaply,
with
little
Conducting
polymers
(CPs)
are
significant
family
functional
materials
that
have
garnered
interest
research
community
their
high
conductivity,
outstanding
sustainability,
economic
significance.
They
extensive
number
applications
involving
supercapacitors,
power
sources,
electrochromic
gadgets,
electrostatic
components,
conducting
pastes,
sensors,
biological
thanks
special
physical
electrical
attributes,
ease
synthesis,
appropriate
frameworks
for
attachment.
use
three-dimensional
become
popular
as
exact
way
enhance
prepared
networks.
Rapid
technological
advancements
reproducing
patterns
building
structures
enable
automated
deposition
intricate
structures.
Different
composites
been
created
using
oxides
metals
carbon
improve
efficiency
CPs.
Such
actively
investigated
exceptional
producers
low-power
electronic
techniques,
by
range
applications,
verified
surface
area,
remarkable
electrochemical
behavior.
hybridization
such
produced
equipment,
gathering
energy,
protective
storage
facilities.
A
few
possible
uses
CPs
sensors
discussed
this
perspective.
We
also
provide
overview
key
strategies
scientific
industrial
eye
on
potential
improvements
future.
Polymers for Advanced Technologies,
Год журнала:
2025,
Номер
36(4)
Опубликована: Март 31, 2025
ABSTRACT
3D
printing
technology
has
shown
significant
promise
in
bone
tissue
engineering,
enabling
the
fabrication
of
intricate
structures
while
controlling
porosity
and
mechanical
properties.
Integrating
into
provides
a
vital
benefit
by
allowing
implants
to
precisely
match
an
individual's
anatomy,
improving
outcomes
reducing
risk
rejection.
Additionally,
this
approach
supports
inclusion
bioactive
substances
growth
factors
enhance
regeneration.
This
study
examines
most
recent
advances
for
production,
stressing
their
potential
regenerative
medicine
personalized
healthcare.
It
also
addresses
challenges
associated
with
current
processes
engineering
explores
possible
avenues
future
research
development.
Furthermore,
article
investigates
how
biocompatibility
bioactivity
materials
used
facilitate
effective
Likewise,
it
evaluates
scaffold
design
architecture
can
promote
cell
attachment,
proliferation,
differentiation,
thereby
encouraging
successful
restoration.
In
conclusion,
thorough
assessment
offers
critical
insights
progress
obstacles
proposes
directions
inquiry
exciting
field.
By
leveraging
these
advancements,
clinicians
researchers
pioneer
new
therapies
that
address
defects
improve
outcomes.
