Wood flour and kraft lignin enable air-drying of the nanocellulose-based 3D-printed structures DOI Creative Commons
Maryam Borghei, Hossein Baniasadi, Roozbeh Abidnejad

et al.

Additive manufacturing, Journal Year: 2024, Volume and Issue: 92, P. 104397 - 104397

Published: July 1, 2024

The predominant technique for producing 3D-printed structures of nanocellulose involves freeze-drying despite its drawbacks in terms energy consumption and carbon footprint. This study explores the less-energy-intensive drying approach by leveraging valorization forest residual streams. We utilized wood flour Kraft lignin as fillers to facilitate room-temperature nanocellulose-based 3D printed structures. Various ink formulations, integrating cellulose nanofibers, flour, lignin, were tested direct writing (DIW). formulations exhibited shear-thinning behavior distinct yield stress with rising levels, ensuring effective flow during DIW. Consequently, multilayered objects high shape fidelity precise dimensions. Lignin prevented structural collapse upon drying. A reduced shrinkage was observed addition freeze room temperature Moreover, dried samples denser demonstrated significantly higher resistance applied compressive force, surpassing those reported cellulose-based composites existing literature. Remarkably, trade-off effects are highlighted efficient stress-distributing micro-scale sliding, enabling better strength. Along it further increases thermal stability. However, hinders hierarchical porous structure, main ion transportation channels, reducing double-layer capacitance carbonized Overall, results underscore potential all-biobased DIW practical applications, highlighting their enhanced mechanical properties integrity via more sustainable method.

Language: Английский

Hydrogel-Based Inks for Extrusion 3D Printing: A Rheological Viewpoint DOI
Prachi Thareja, Sanchari Swarupa, Sharif Ahmad

et al.

Current Opinion in Colloid & Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 101918 - 101918

Published: March 1, 2025

Language: Английский

Citations

2
Promising New Horizons in Medicine: Medical Advancements with Nanocomposite Manufacturing via 3D Printing DOI Open Access
Nan Li, Sadaf Bashir Khan, Shenggui Chen

et al.

Polymers, Journal Year: 2023, Volume and Issue: 15(20), P. 4122 - 4122

Published: Oct. 17, 2023

Three-dimensional printing technology has fundamentally revolutionized the product development processes in several industries. enables creation of tailored prostheses and other medical equipment, anatomical models for surgical planning training, even innovative means directly giving drugs to patients. Polymers their composites have found broad usage healthcare business due many beneficial properties. As a result, application 3D area transformed design manufacturing devices prosthetics. become attractive materials this industry because unique mechanical, thermal, electrical, optical qualities. This review article presents comprehensive analysis current state-of-the-art applications polymer its field using technology. It covers latest research developments patient-specific devices, prostheses, training. The also discusses use drug delivery systems (DDS) tissue engineering. Various techniques, such as stereolithography, fused deposition modeling (FDM), selective laser sintering (SLS), are reviewed, along with benefits drawbacks. Legal regulatory issues related addressed. concludes an outlook on future potential field. findings indicate that enormous revolutionize manufacture leading improved patient outcomes better services.

Language: Английский

Citations

21
High-throughput bioprinting of spheroids for scalable tissue fabrication DOI Creative Commons
Myoung Hwan Kim, Yogendra Pratap Singh, Nazmiye Celik

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 21, 2024

Tissue biofabrication mimicking organ-specific architecture and function requires physiologically-relevant cell densities. Bioprinting using spheroids can achieve this, but is limited due to the lack of practical, scalable techniques. This study presents HITS-Bio (High-throughput Integrated Fabrication System for Bioprinting), a multiarray bioprinting technique rapidly positioning multiple simultaneously digitally-controlled nozzle array (DCNA). achieves an unprecedented speed, ten times faster compared existing techniques while maintaining high viability ( > 90%). The utility was exemplified in applications, including intraoperative with microRNA transfected human adipose-derived stem calvarial bone regeneration ~ 30 mm3) rat model achieving near-complete defect closure (bone coverage area 91% 3 weeks ~96% 6 weeks). Additionally, successful fabrication cartilage constructs (1 cm3) containing ~600 chondrogenic highlights its high-throughput efficiency (under 40 min per construct) potential repairing volumetric defects. HITS-Bio, platform, assembles mimic native tissue architecture. Its application shows repair rats cartilage.

Language: Английский

Citations

8
Advances in Cell‐Rich Inks for Biofabricating Living Architectures DOI
J. Almeida-Pinto, Beatriz S. Moura, Vítor M. Gaspar

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(27)

Published: April 19, 2024

Abstract Advancing biofabrication toward manufacturing living constructs with well‐defined architectures and increasingly biologically relevant cell densities is highly desired to mimic the biofunctionality of native human tissues. The formulation tissue‐like, cell‐dense inks for remains, however, challenging at various levels bioprinting process. Promising advances have been made this goal, achieving relatively high that surpass those found in conventional platforms, pushing current boundaries closer tissue‐like densities. On focus, herein overarching challenges bioprocessing cell‐rich into clinically grade engineered tissues are discussed, as well most recent ink formulations their processing technologies highlighted. Additionally, an overview foreseen developments field provided critically discussed.

Language: Английский

Citations

7
Rheological Characterization and Printability of Sodium Alginate–Gelatin Hydrogel for 3D Cultures and Bioprinting DOI Creative Commons
Mohan Kumar Dey, Ram V. Devireddy

Biomimetics, Journal Year: 2025, Volume and Issue: 10(1), P. 28 - 28

Published: Jan. 4, 2025

The development of biocompatible hydrogels for 3D bioprinting is essential creating functional tissue models and advancing preclinical drug testing. This study investigates the formulation, printability, mechanical properties, biocompatibility a novel Alg-Gel hydrogel blend (alginate gelatin) use in extrusion-based bioprinting. A range compositions were evaluated their rheological behavior, including shear-thinning storage modulus, compressive which are crucial maintaining structural integrity during printing supporting cell viability. printability assessment 7% alginate-8% gelatin demonstrated that 27T tapered needle achieved highest normalized Printability Index (POInormalized = 1), offering narrowest strand width (0.56 ± 0.02 mm) accuracy (97.2%) at lowest pressure (30 psi). In contrast, 30R needle, with smallest inner diameter (0.152 (80 psi), resulted widest (0.70 0.01 (88.8%), resulting POInormalized 0.274. 30T 27R needles moderate performance, values 0.758 0.558, respectively. optimized alginate 8% favorable strength, compatibility MDA-MB-213 breast cancer cells, exhibiting high proliferation rates minimal cytotoxicity over 2-week culture period. formulation offers balanced approach, providing sufficient viscosity precision while minimizing shear stress to preserve health. work lays groundwork future advancements bioprinted models, contributing more effective tools screening personalized medicine.

Language: Английский

Citations

1
INNOVATIVE ZEIN-DERIVED INKS: TOWARDS SUSTAINABLE 3D PRINTING SOLUTIONS DOI Creative Commons

Derniza‐Elena Cozorici,

Erika Blanzeanu, Ionuț-Cristian Radu

et al.

Results in Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 104017 - 104017

Published: Jan. 1, 2025

Language: Английский

Citations

1
Mucin-Based Dual Cross-Linkable IPN Hydrogel Bioink for 3D Bioprinting and Cartilage Tissue Engineering DOI

Sruthi C. Sasikumar,

Upashi Goswami, Ashok M. Raichur

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

The cartilage possesses limited regenerative capacity, necessitating advanced approaches for its repair. This study introduces a bioink designed tissue engineering (TE) by incorporating ionically cross-linkable alginate into the photo-cross-linkable MuMA bioink, resulting in double cross-linked interpenetrating network (IPN) hydrogel. Additionally, hyaluronic acid (HA), natural component of and synovial fluid, was added to enhance scaffold's properties. HA has been demonstrated improve lubrication, regulate inflammation, promote cell proliferation, support extracellular matrix (ECM) deposition regeneration, making it valuable TE. Comprehensive experiments were conducted assess morphology, swelling, degradation, mechanical rheological properties, printability, biocompatibility. Results indicated that scaffolds comprising MuMA, alginate, exhibited compressive moduli comparable native cartilage, unlike single variants. cross-linking also influenced water uptake, porosity, contributing scaffold durability stability chondrocyte support. Biocompatibility tests with C28/I2 cells cell-supportive chondrogenic potential bioink. establishes mucin as versatile material specialized applications.

Language: Английский

Citations

1
The Multifaceted Role of 3D Printed Conducting Polymers in Next-Generation Energy Devices: A Critical Perspective DOI Creative Commons
Nipun Jain, Yusuf Olatunji Waidi

JACS Au, Journal Year: 2025, Volume and Issue: 5(2), P. 411 - 425

Published: Jan. 22, 2025

The increasing human population is leading to growing consumption of energy sources which requires development in devices. modern iterations these devices fail offer sustainable and environmentally friendly answers since they require costly equipment produce a lot waste. Three-dimensional (3D) printing has spurred incredible innovation over the years variety fields clearly an attractive option because technology can create unique geometric items quickly, cheaply, with little Conducting polymers (CPs) are significant family functional materials that have garnered interest research community their high conductivity, outstanding sustainability, economic significance. They extensive number applications involving supercapacitors, power sources, electrochromic gadgets, electrostatic components, conducting pastes, sensors, biological thanks special physical electrical attributes, ease synthesis, appropriate frameworks for attachment. use three-dimensional become popular as exact way enhance prepared networks. Rapid technological advancements reproducing patterns building structures enable automated deposition intricate structures. Different composites been created using oxides metals carbon improve efficiency CPs. Such actively investigated exceptional producers low-power electronic techniques, by range applications, verified surface area, remarkable electrochemical behavior. hybridization such produced equipment, gathering energy, protective storage facilities. A few possible uses CPs sensors discussed this perspective. We also provide overview key strategies scientific industrial eye on potential improvements future.

Language: Английский

Citations

1
Maximizing sorghum proteins printability: Optimizing gel formulation and 3D-printing parameters to develop a novel bioink DOI
Sorour Barekat, Ali Ubeyitogullari

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140245 - 140245

Published: Jan. 1, 2025

Language: Английский

Citations

1
Three‐Dimensional Printing Applications for Bone Tissue Engineering: A Review DOI Open Access
Saeedeh Zare Jalise, Arezou Mehrabi, Sina Habibi

et al.

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(4)

Published: March 31, 2025

ABSTRACT 3D printing technology has shown significant promise in bone tissue engineering, enabling the fabrication of intricate structures while controlling porosity and mechanical properties. Integrating into provides a vital benefit by allowing implants to precisely match an individual's anatomy, improving outcomes reducing risk rejection. Additionally, this approach supports inclusion bioactive substances growth factors enhance regeneration. This study examines most recent advances for production, stressing their potential regenerative medicine personalized healthcare. It also addresses challenges associated with current processes engineering explores possible avenues future research development. Furthermore, article investigates how biocompatibility bioactivity materials used facilitate effective Likewise, it evaluates scaffold design architecture can promote cell attachment, proliferation, differentiation, thereby encouraging successful restoration. In conclusion, thorough assessment offers critical insights progress obstacles proposes directions inquiry exciting field. By leveraging these advancements, clinicians researchers pioneer new therapies that address defects improve outcomes.

Language: Английский

Citations

1