Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway
Open Medicine,
Год журнала:
2024,
Номер
19(1)
Опубликована: Янв. 1, 2024
Sepsis
triggers
myocardial
injury
and
dysfunction,
leading
to
a
high
mortality
rate
in
patients.
Cardiomyocyte
apoptosis
plays
positive
regulatory
role
septic
dysfunction.
However,
the
mechanism
is
unclear.
Язык: Английский
Repeated Administration of a Full-Spectrum Cannabidiol Product, Not a Cannabidiol Isolate, Reverses the Lipopolysaccharide-Induced Depressive-Like Behavior and Hypolocomotion in a Rat Model of Low-Grade Subchronic Inflammation
Cannabis and Cannabinoid Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 30, 2024
Mounting
evidence
suggests
that
the
phytocannabinoid
cannabidiol
(CBD)
holds
promise
as
an
antidepressant
agent
in
conditions
underlined
by
inflammation.
Full-spectrum
CBD
extracts
might
provide
greater
behavioral
efficacy
than
CBD-only
isolates
and
require
lower
doses
to
achieve
same
outcomes
due
presence
of
other
cannabinoids,
terpenes,
flavonoids.
However,
investigations
this
area
remain
limited.
Язык: Английский