Repeated Administration of a Full-Spectrum Cannabidiol Product, Not a Cannabidiol Isolate, Reverses the Lipopolysaccharide-Induced Depressive-Like Behavior and Hypolocomotion in a Rat Model of Low-Grade Subchronic Inflammation DOI
Linério Ribeiro de Novais Júnior, Tiago Vicente da Silva, Larissa Mendes da Silva

et al.

Cannabis and Cannabinoid Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Mounting evidence suggests that the phytocannabinoid cannabidiol (CBD) holds promise as an antidepressant agent in conditions underlined by inflammation. Full-spectrum CBD extracts might provide greater behavioral efficacy than CBD-only isolates and require lower doses to achieve same outcomes due presence of other cannabinoids, terpenes, flavonoids. However, investigations this area remain limited.

Language: Английский

Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway DOI Creative Commons

Xueyuan Long,

Yanpeng Yang, Ke Zhou

et al.

Open Medicine, Journal Year: 2024, Volume and Issue: 19(1)

Published: Jan. 1, 2024

Sepsis triggers myocardial injury and dysfunction, leading to a high mortality rate in patients. Cardiomyocyte apoptosis plays positive regulatory role septic dysfunction. However, the mechanism is unclear.

Language: Английский

Citations

1
Repeated Administration of a Full-Spectrum Cannabidiol Product, Not a Cannabidiol Isolate, Reverses the Lipopolysaccharide-Induced Depressive-Like Behavior and Hypolocomotion in a Rat Model of Low-Grade Subchronic Inflammation DOI
Linério Ribeiro de Novais Júnior, Tiago Vicente da Silva, Larissa Mendes da Silva

et al.

Cannabis and Cannabinoid Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Mounting evidence suggests that the phytocannabinoid cannabidiol (CBD) holds promise as an antidepressant agent in conditions underlined by inflammation. Full-spectrum CBD extracts might provide greater behavioral efficacy than CBD-only isolates and require lower doses to achieve same outcomes due presence of other cannabinoids, terpenes, flavonoids. However, investigations this area remain limited.

Language: Английский

Citations

0