Future Applications of Central Neuromodulation and Neurophysiological Testing in Cyclic Vomiting Syndrome DOI Creative Commons
David J. Levinthal, Braden Kuo

Neurogastroenterology & Motility, Год журнала: 2024, Номер unknown

Опубликована: Дек. 31, 2024

Cyclic vomiting syndrome (CVS) is defined by its episodic patterning. Furthermore, CVS associated with other disorders such as migraine and epilepsy. Indeed, many of the medications that are known to be useful for prophylaxis abortive therapy in also effective preventing aborting migraines seizures. These observations strongly suggest has a neural basis, but precise pathophysiological mechanisms operate remain unclear.

Язык: Английский

The relationship between parameters and effects in transcranial ultrasonic stimulation. DOI Creative Commons
Tulika Nandi, Benjamin R. Kop,

Kim Butts Pauly

и другие.

Brain stimulation, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

11
Thalamic transcranial ultrasound stimulation in treatment resistant depression DOI Creative Commons
Joline M. Fan,

Kai Woodworth,

Keith R. Murphy

и другие.

Brain stimulation, Год журнала: 2024, Номер 17(5), С. 1001 - 1004

Опубликована: Авг. 23, 2024

Язык: Английский

Процитировано

11
Individualized non-invasive deep brain stimulation of the basal ganglia using transcranial ultrasound stimulation DOI Creative Commons
Ghazaleh Darmani, Hamidreza Ramezanpour, Can Sarica

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Март 19, 2025

Transcranial ultrasound stimulation (TUS) offers precise, non-invasive neuromodulation, though its impact on human deep brain structures remains underexplored. Here we examined TUS-induced changes in the basal ganglia of 10 individuals with movement disorders (Parkinson's disease and dystonia) 15 healthy participants. Local field potentials were recorded using (DBS) leads globus pallidus internus (GPi). Compared to sham, theta burst TUS (tbTUS) increased power during stimulation, while Hz enhanced beta power, effects lasting up 40 min. In participants, a stop-signal task assessed tbTUS GPi, pulvinar serving as an active sham. GPi prolonged reaction times, indicating impaired response inhibition, whereas had no effect. These findings provide direct electrophysiological evidence target engagement specificity structures, suggesting potential noninvasive DBS strategy for neurological psychiatric disorders. is method modulate activity. Using recordings from implanted electrodes, showed that engages internus, neural oscillations behavior.

Язык: Английский

Процитировано

2
Current state of clinical ultrasound neuromodulation DOI Creative Commons
Eva Matt, Sonja Radjenovic,

Michael Mitterwallner

и другие.

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Июнь 19, 2024

Unmatched by other non-invasive brain stimulation techniques, transcranial ultrasound (TUS) offers highly focal not only on the cortical surface but also in deep structures. These unique attributes are invaluable both basic and clinical research might open new avenues for treating neurological psychiatric diseases. Here, we provide a concise overview of expanding volume investigations recent years upcoming initiatives concerning focused neuromodulation. Currently, TUS addresses variety neuropsychiatric conditions, such as pain, dementia, movement disorders, epilepsy, disorders consciousness, developmental disorders. As demonstrated sham-controlled randomized studies, neuromodulation improved cognitive functions mood, alleviated symptoms schizophrenia autism. Further, preliminary uncontrolled evidence suggests relieved anxiety, enhanced motor reduced epileptic seizure frequency, responsiveness patients with minimally conscious state, well pain reduction after neuromodulatory TUS. While constrained relatively modest number investigations, primarily consisting feasibility trials small sample sizes, holds encouraging prospects Larger trials, alongside further into mechanisms action optimal sonication parameters, inevitably needed to unfold full potential

Язык: Английский

Процитировано

7
Transcranial focused ultrasound activates feedforward and feedback cortico-thalamo-cortical pathways by selectively activating excitatory neurons DOI

Huan Gao,

Sandhya Ramachandran, Kai Yu

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 30, 2024

Abstract Transcranial focused ultrasound stimulation (tFUS) has been proven capable of altering focal neuronal activities and neural circuits non-invasively in both animals humans. The abilities tFUS for cell-type selection within the targeted area like somatosensory cortex have shown to be parameter related. However, how subpopulations across pathways are affected, example affected connections between brain areas remains unclear. In this study, multi-site intracranial recordings were used quantify responses at (S1), motor (M1) posterior medial thalamic nucleus (POm) cortico-thalamo-cortical (CTC) pathway. We found that when targeting S1 or POm, only regular spiking units (RSUs, putative excitatory neurons) responded specific parameters (duty cycle: 6%-60% pulse repetition frequency: 1500 3000 Hz ) during sonication. RSUs from directly connected (POm S1) showed a synchronized response, which changed directional correlation POm S1. induced excitation activated feedforward feedback loops thalamus, eliciting delayed fast (FSUs) by affecting local network. Our findings indicated can modulate CTC pathway through loops, could influence larger cortical including cortex.

Язык: Английский

Процитировано

4
Low-intensity focused ultrasound for human neuromodulation DOI
Wynn Legon, Andrew Strohman

Nature Reviews Methods Primers, Год журнала: 2024, Номер 4(1)

Опубликована: Дек. 19, 2024

Язык: Английский

Процитировано

4
Examination of the interaction of parameters for low-intensity focused ultrasound of the human motor cortex DOI Creative Commons

Areej Ennasr,

G. Anand Isaac,

Andrew Strohman

и другие.

Brain stimulation, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Low-intensity focused ultrasound (LIFU) is a promising form of non-invasive neuromodulation characterized by rich parameter space that includes intensity, duration, duty cycle and pulsing strategy. The effect interaction these parameters to affect human brain activity poorly understood. A better understanding how interact critical advance LIFU as potential therapeutic.

Язык: Английский

Процитировано

3
Spinal Cord Ultrasound Stimulation Modulates Corticospinal Excitability DOI Creative Commons
Lin Hou, Yuming Lei

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Abstract Background Low-intensity focused ultrasound (LIFU) offers superior tissue penetration and enables precise neuromodulation of cortical subcortical circuits. However, its effects on neural activity in the human spinal cord remain largely unexplored. Objective To investigate LIFU under varying conditions intensity (spatial-peak pulse-average intensity, I SPPA ), duty cycle (DC), pulse repetition frequency (PRF). Methods Thirty-six healthy volunteers participated study. A 500 kHz transducer with a focal depth exceeding 100 mm was used to target C8 cord. Transcranial magnetic stimulation (TMS) applied primary motor cortex (M1) hotspot corresponding first dorsal interosseous (FDI) muscle, innervated by nerve. ms-duration delivered 400 ms prior single-pulse TMS over FDI hotspot. Spinal (SCUS) administered acoustic parameters: intensities (I : 2.5 10 W/cm²), DCs (10% 30%), PRFs (500 1000 Hz). Changes corticospinal excitability were assessed comparing TMS-elicited motor-evoked potentials (MEPs) between active sham SCUS conditions. Results an W/cm², DC 30%, PRF Hz significantly reduced MEP amplitudes compared stimulation. at high 10% 30% did not affect amplitudes. Additionally, while decreased produce significant changes. Conclusions The results indicate that can suppress drive muscles, especially when utilizing parameters. This suggests may provide novel method for modulating activity.

Язык: Английский

Процитировано

0
Enhancing transcranial ultrasound stimulation planning with MRI-derived skull masks: a comparative analysis with CT-based processing DOI Creative Commons
Ali K. Zadeh, Oula Puonti, Björn Sigurðsson

и другие.

Journal of Neural Engineering, Год журнала: 2025, Номер 22(1), С. 016020 - 016020

Опубликована: Янв. 30, 2025

Abstract Objective. Transcranial ultrasound stimulation (TUS) presents challenges in wave transmission through the skull, affecting study outcomes due to aberration and attenuation. While planning strategies incorporating 3D computed tomography (CT) scans help mitigate these issues, they expose participants radiation, which can raise ethical concerns. A solution involves generating skull masks from participants’ anatomical magnetic resonance imaging (MRI). This aims compare field predictions between CT-derived MRI-derived TUS planning. Approach. Five with a range of density ratios (SDRs: 0.31, 0.42, 0.55, 0.67, 0.79) were selected, each having both CT T1/T2-weighted MRI scans. Ultrasound simulations performed using BabelBrain software single-element transducer (diameter = 50 mm, F # 1) at 250, 500, 750 kHz frequencies. used generate maps skull’s acoustic properties. The processed Charm segmentation tool SimNIBS suite default custom settings adapted for better segmentation. was adjusted target 30 mm below surface 54 electroencephalogram (EEG) locations. Main Results. setting significantly improved Dice coefficient MRI- when compared ( p < 0.001). maximum pressure error decreased Additionally, focus location median across different SDRs averaged 2.32, 1.45, 1.57 2.08, 1.38, 1.44 conditions 250 kHz, 500 respectively. Significance. offer satisfactory accuracy many EEG sites, further enhance this accuracy. However, significant errors specific locations highlight importance carefully considering choosing CT- modeling.

Язык: Английский

Процитировано

0
Delay- and Pressure-Dependent Neuromodulatory Effects of Transcranial Ultrasound Stimulation DOI Creative Commons
Cyril Atkinson-Clément,

Mohammad Alkhawashki,

Marilyn Gatica

и другие.

Neuromodulation Technology at the Neural Interface, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Despite the growing interest in transcranial focused ultrasound stimulation (TUS), our understanding of its underlying mechanisms remains limited. In this study, we aimed to investigate effects TUS on several functional magnetic resonance imaging metrics by considering their latency, duration, and relationship with applied acoustic pressure. We recruited 22 healthy volunteers used a pre- vs post-TUS protocol. Half were stimulated right inferior frontal cortex other half thalamus. The fractional amplitudes low-frequency fluctuations, regional homogeneity, degree centrality, local connectivity density, eigenvector centrality considered. These compared before at three different time points first hour after TUS. Our results showed that 1) primarily alters both global levels; 2) stronger alterations are observed when delay increases 3) pressure is close maximum. suggest some consequences might not be immediate, inviting us revise premise immediate will progressively disappear.

Язык: Английский

Процитировано

0