Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 17, 2024
Язык: Английский
Drug Resistance Updates, Год журнала: 2024, Номер 73, С. 101040 - 101040
Опубликована: Янв. 9, 2024
Язык: Английский
Процитировано
12
Cancer Letters, Год журнала: 2024, Номер 598, С. 217096 - 217096
Опубликована: Июль 4, 2024
Язык: Английский
Процитировано
11
Cancer Letters, Год журнала: 2024, Номер 604, С. 217258 - 217258
Опубликована: Сен. 13, 2024
Язык: Английский
Процитировано
6
Cancer Letters, Год журнала: 2024, Номер 598, С. 217117 - 217117
Опубликована: Июль 15, 2024
Cancer cells rewire metabolism to sculpt the immune tumor microenvironment (TME) and propel advancement, which intricately tied post-translational modifications. Histone lactylation has emerged as a novel player in modulating protein functions, whereas little is known about its pathological role pancreatic ductal adenocarcinoma (PDAC) progression. Employing multi-omics approach encompassing bulk single-cell RNA sequencing, metabolomics, ATAC-seq, CUT&Tag methodologies, we unveiled potential of histone prognostic prediction, patient stratification TME characterization. Notably, "LDHA-H4K12la-immuno-genes" axis introduced node into regulatory framework "metabolism-epigenetics-immunity," shedding new light on landscape PDAC Furthermore, heightened interplay between cancer counterparts via Nectin-2 liver metastasis with elevated HLS unraveled positive feedback loop driving evasion. Simultaneously, exhibited altered autonomous functionality across metastatic cascade. Consequently, exploration innovative combination strategies targeting metabolism-epigenetics-immunity holds promise curbing distant improving survival prospects for individuals grappling challenges PDAC.
Язык: Английский
Процитировано
5
Cancer Letters, Год журнала: 2024, Номер 611, С. 217428 - 217428
Опубликована: Дек. 24, 2024
The oncoimmunology research has witnessed notable advancements in recent years. Reshaping the tumor microenvironment (TME) approach is an effective method to improve antitumor immune response. T cell-mediated response crucial for favorable therapeutic outcomes several cancers. United States Food and Drug Administration (FDA) approved checkpoint inhibitors (ICIs) targeting proteins (ICPs) expressed various hematological solid malignancies. ICPs are cell co-inhibitory molecules that block activation and, thus, Currently, most of FDA-approved ICIs antagonistic antibodies programmed death-ligand 1 (PD-L1), death protein (PD-1), cytotoxic T-lymphocyte-associated 4 (CTLA-4). In contrast ICPs, costimulatory required activation, expansion, effector function. However, abrupt expression these tumors presents a concern One molecules, cluster differentiation 70 (CD70), emerged as druggable target malignancies due its role function evasion. present review describes CD70, factors affecting CD70 expression, physiological clinical relevance current approaches
Язык: Английский
Процитировано
5
Journal of Photochemistry and Photobiology B Biology, Год журнала: 2025, Номер 265, С. 113126 - 113126
Опубликована: Фев. 19, 2025
Язык: Английский
Процитировано
0
Cancer Letters, Год журнала: 2024, Номер 599, С. 217152 - 217152
Опубликована: Июль 31, 2024
Язык: Английский
Процитировано
3
World Journal of Gastrointestinal Oncology, Год журнала: 2024, Номер 16(4), С. 1134 - 1153
Опубликована: Апрель 9, 2024
Pancreatic cancer (PC) is characterized by its extremely aggressive nature and ranks 14th in the number of new cases worldwide. However, due to complexity, it 7th list most lethal cancers The pathogenesis PC involves several complex processes, including familial genetic factors associated with risk such as obesity, diabetes mellitus, chronic pancreatitis, smoking. Mutations genes KRAS, TP53 , SMAD4 are linked appearance malignant cells that generate pancreatic lesions and, consequently, cancer. In this context, some therapies used for PC, one which immunotherapy, promising various other types but has shown little response treatment resistance mechanisms contribute a drop immunotherapy efficiency. It therefore clear tumor microenvironment (TME) huge impact on process, since cellular non-cellular elements create an immunosuppressive environment, dense desmoplastic stroma cancer-associated fibroblasts, stellate cells, extracellular matrix, cells. Linked mutations act T resulting shortage CD8+ limited expression activation markers interferon-gamma. way, finding strategies make possible manipulate necessary. Thus, techniques use TME modulators block receptors stromal molecules resistance, manipulation specific regions, microRNAs, modulation extrinsic intrinsic above all, therapeutic models combine these constitute future therapy. study aims elucidate main ways manipulating more efficient therapy patients reduction lethality
Язык: Английский
Процитировано
2
Cancer Letters, Год журнала: 2024, Номер 603, С. 217202 - 217202
Опубликована: Авг. 30, 2024
Язык: Английский
Процитировано
1
Cancer Letters, Год журнала: 2024, Номер 605, С. 217287 - 217287
Опубликована: Окт. 9, 2024
Owing to the desmoplastic stroma constituted by cancer-associated fibroblasts (CAFs), few immune cells infiltrate pancreatic ductal adenocarcinoma (PDAC). Gabapentin can impede production of ketoacids CAFs support cancer cells. However, in our study, we discovered a dose-dependent increase transforming growth factor β1 (TGF-β1) levels response gabapentin. This reverse TGF-β1 contributes 'Gabapentin-resistance', leading antitumor effects on PDAC cell lines are negatively negotiated presence stellate Pirfenidone synergistically inhibited and apoptosis resistance when combined with Gabapentin. In mouse orthotopic model, Fe
Язык: Английский
Процитировано
1