The antioxidant activity of polysaccharides: A structure-function relationship overview

Carbohydrate Polymers, Год журнала: 2023, Номер 314, С. 120965 - 120965

Опубликована: Апрель 28, 2023

Over the last years, polysaccharides have been linked to antioxidant effects using both in vitro chemical and biological models. The reported structures, claimed act as antioxidants, comprise chitosan, pectic polysaccharides, glucans, mannoproteins, alginates, fucoidans, many others of all type sources. structural features action include polysaccharide charge, molecular weight, occurrence non-carbohydrate substituents. establishment structure/function relationships can be, however, biased by secondary phenomena that tailor behavior systems. In this sense, review confronts some basic concepts chemistry with current claim carbohydrates antioxidants. It critically discusses how fine structure properties define Polysaccharides is highly dependent on their solubility, sugar ring structure, positive or negatively charged groups, protein moieties covalently phenolic compounds. However, compounds contaminants leads misleading results methodologies often used for screening characterization purposes, well vivo Despite falling concept role must be defined according matrices where they are involved.

Язык: Английский

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Multiple Stimuli‐Responsive Nanozyme‐Based Cryogels with Controlled NO Release as Self‐Adaptive Wound Dressing for Infected Wound Healing

Advanced Functional Materials, Год журнала: 2023, Номер 33(31)

Опубликована: Апрель 23, 2023

Abstract Wound with drug‐resistant bacterial infections has become a serious challenge for the healthcare system, and designing wound dressing to self‐adapt need of different stage healing remains challenging. Herein, self‐adaptive dressings multiple stimuli‐responsiveness antibacterial activity are developed. Specifically, MoS 2 carrying reactive oxygen species (ROS) responsive nitric oxide (NO) release precursor L‐arginine (MSPA) is designed incorporated into carboxymethyl chitosan/ poly( N‐isopropylacrylamide) based cryogels (CMCS/PNIPAM) responsiveness (pH, near infrared (NIR), temperature) form that adapt therapeutic needs stages in infected healing. In response slightly acidic environment infection, assist capture capacity through acid‐triggered protonation behavior, effectively enhance photodynamic efficiency. Controllable on‐demand delivery ROS, NO, remote management biofluid achieved NIR light as trigger switch. The stimuli‐responsive nanozyme‐based efficiently eliminate MRSA biofilm NO assisted photodynamicand photothermal therapy (PDT&PTT). enzyme‐like activities relieved oxidative damage. Notably, these reduce alleviated stress, accelerate collagen deposition angiogenesis wounds, indicating provide new ideas treatment.

Язык: Английский

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Recent Applications of Chitosan and Its Derivatives in Antibacterial, Anticancer, Wound Healing, and Tissue Engineering Fields

Polymers, Год журнала: 2024, Номер 16(10), С. 1351 - 1351

Опубликована: Май 10, 2024

Chitosan, a versatile biopolymer derived from chitin, has garnered significant attention in various biomedical applications due to its unique properties, such as biocompatibility, biodegradability, and mucoadhesiveness. This review provides an overview of the diverse chitosan derivatives antibacterial, anticancer, wound healing, tissue engineering fields. In antibacterial applications, exhibits potent antimicrobial properties by disrupting microbial membranes DNA, making it promising natural preservative agent against bacterial infections. Its role cancer therapy involves development chitosan-based nanocarriers for targeted drug delivery, enhancing therapeutic efficacy while minimising side effects. Chitosan also plays crucial healing promoting cell proliferation, angiogenesis, regulating inflammatory responses. Additionally, serves multifunctional scaffold engineering, facilitating regeneration tissues cartilage, bone, neural adhesion proliferation. The extensive range pharmaceutical sciences is not only highlighted comprehensive scope this review, but establishes fundamental component forthcoming research biomedicine.

Язык: Английский

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Mussel-inspired “all-in-one” sodium alginate/carboxymethyl chitosan hydrogel patch promotes healing of infected wound

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 261, С. 129828 - 129828

Опубликована: Янв. 29, 2024

Язык: Английский

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Chitosan-based nanofibrous scaffolds for biomedical and pharmaceutical applications: A comprehensive review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 264, С. 130683 - 130683

Опубликована: Март 6, 2024

Язык: Английский

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A Cellulose/Chitosan Dual Cross‐Linked Multifunctional and Resilient Hydrogel for Emergent Open Wound Management

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(13)

Опубликована: Янв. 31, 2024

Adhesive hydrogel holds huge potential in biomedical applications, such as hemostasis and emergent wound management during outpatient treatment or surgery. However, most adhesive hydrogels underperform to offer robust adhesions on the wet tissue, increasing risk of hemorrhage reducing fault tolerance To address this issue, work develops a polysaccharide-based bioadhesive tape (ACAN) consisting dual cross-linking allyl cellulose (AC) carboxymethyl chitosan (CMCS). The hygroscopicity AC CMCS networks enables ACAN remove interfacial water from tissue surface initializes physical cross-link instantly. Subsequently, covalent cross-links are developed with amine moieties sustain long-term adhesion. cross-linked also has good cytocompatibility controllable mechanical properties matching where addition provides remarkable antibacterial hemostatic capability. Moreover, compared commercially available 3 M film, an ultrafast healing tissue. hybrid have advantages biocompatibility antibacterial, hemostatic, properties, shedding new light first-aid design advancing cellulose-based materials technology for high-performance applications.

Язык: Английский

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A novel chitosan antioxidant bearing sulfhydryl group: Synthesis, characterization and activity assessment

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 261, С. 129816 - 129816

Опубликована: Янв. 28, 2024

Язык: Английский

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Hemostatic Tranexamic Acid-Induced Fast Gelation and Mechanical Reinforcement of Polydimethylacrylamide/Carboxymethyl Chitosan Hydrogel for Hemostasis and Wound Healing

Biomacromolecules, Год журнала: 2024, Номер 25(2), С. 819 - 828

Опубликована: Янв. 22, 2024

The combinational properties with excellent mechanical properties, adhesive performance, hemostatic ability, antibacterial action, and wound healing efficacy are highly desirable for injectable hydrogels' practical applications in hemorrhage control closure, but designing one single hydrogel system integrating such is still difficult. Herein, a simplified yet straightforward strategy proposed to prepare an robust poly(N,N-dimethylacrylamide) (PDMAA)/carboxymethyl chitosan (CMCS) induced by tranexamic acid (TXA). TXA not only promotes the rapid generation of free radicals also introduces multiple hydrogen bonds into network. Moreover, as common clinical drug, itself has effects. In addition, CMCS imparts sterilization hemostasis effects hydrogel, thereby promoting healing. Besides, amino carboxyl groups on molecules hydroxyl, amino, can form wet biological tissues, leading good tissue adhesion hydrogel. As result, (up 1.83 MPa at 90% compression strain), performance 18.7 kPa strength porcine skin tissue), biocompatibility, activity, be fabricated within several minutes. These advantages enable efficiently stop (blood loss amount: 110 mg; time: 25 s) promote process (wound closure rate 2 weeks: 83%), which verified using rat models liver bleeding infected full thickness defect. Overall, this facile design incorporating unique will greatly advance hydrogel's application

Язык: Английский

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Protamine-grafted carboxymethyl chitosan based hydrogel with adhesive and long-term antibacterial properties for hemostasis and skin wound healing

Carbohydrate Polymers, Год журнала: 2024, Номер 336, С. 122125 - 122125

Опубликована: Апрель 3, 2024

Язык: Английский

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Advances in chitosan-based blends as potential drug delivery systems: A review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 273, С. 132916 - 132916

Опубликована: Июнь 5, 2024

Язык: Английский

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