Gelatin/carboxymethyl chitosan/aloe juice hydrogels with skin-like endurance and quick recovery: Preparation, characterization, and properties

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 261, С. 129720 - 129720

Опубликована: Янв. 29, 2024

Язык: Английский

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A Microenvironment‐Responsive, Controlled Release Hydrogel Delivering Embelin to Promote Bone Repair of Periodontitis via Anti‐Infection and Osteo‐Immune Modulation

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Июль 8, 2024

Periodontitis, a prevalent chronic inflammatory disease, poses significant challenges for effective treatment due to its complex etiology involving specific bacteria and the immune microenvironment. Here, this study presents novel approach targeted of periodontitis utilizing immunomodulatory antibacterial properties Embelin, plant-derived compound, within an injectable hydrogel system. The developed Carboxymethyl Chitosan-Oxidized Dextran (CMCS-OD) formed via dynamic chemical bonds exhibited self-healing capabilities pH-responsive behavior, thereby facilitating controlled release Embelin enhancing efficacy in oral This demonstrates that system effectively prevents bacterial invasion mitigates excessive response activation. Moreover, it precisely modulates macrophage M1/M2 phenotypes suppresses cytokine expression, fostering conducive environment bone regeneration addressing periodontitis-induced loss. These findings highlight potential as promising strategy clinical management destruction.

Язык: Английский

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Recent functionality developments of carboxymethyl chitosan as an active food packaging film material

Food Chemistry, Год журнала: 2024, Номер 463, С. 141356 - 141356

Опубликована: Сен. 19, 2024

Язык: Английский

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Self-Adapting Biomass Hydrogel Embodied with miRNA Immunoregulation and Long-Term Bacterial Eradiation for Synergistic Chronic Wound Therapy

ACS Nano, Год журнала: 2024, Номер 18(28), С. 18379 - 18392

Опубликована: Июль 2, 2024

Chronic wound rescue is critical for diabetic patients but challenging to achieve with a specific and long-term strategy. The prolonged bacterial inflammation particularly prevalent in hyperglycemia-induced wounds, usually leading severe tissue damage. Such trend could further suffer from an environmental suitability provided by macrophages persisting Staphylococcus aureus (S. aureus) even deteriorate their mutual reinforcement. However, the strategy of both suppressing bacteria growth immunoreprogramming inflammatory type break vicious harm healing still lacking. Here, self-adapting biomass carboxymethyl chitosan (CMC) hydrogel comprising immunomodulatory nanoparticles reported Gram-negative/Gram-positive elimination anti-inflammatory cytokines induction ameliorate cutaneous microenvironment. Mechanistically, antibacterial peptides CMCs synergistically result inhibition against methicillin-resistant S. (MRSA) over period 7 days, miR-301a reprograms M2 macrophage via PTEN/PI3Kγ/mTOR signaling pathway, consequently mitigating promoting angiogenesis rats. In this vein, immunoregulatory promising all-biomass dressing ensuring biocompatibility, providing perspective regenerate damaged tissue, repairing chronic wounds on skin.

Язык: Английский

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Preparation of hydrogel using catechin-grafted chitosan and carboxymethyl cellulose

Macromolecular Research, Год журнала: 2024, Номер 32(7), С. 703 - 715

Опубликована: Апрель 22, 2024

Язык: Английский

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