Advanced Functional Materials,
Год журнала:
2024,
Номер
34(24)
Опубликована: Фев. 16, 2024
Abstract
Diabetic
wounds
are
difficult
to
heal,
and
the
key
wound
healing
is
exudate
management
effective
disinfection.
Inspired
by
asymmetric
wettability
of
Janus‐structured
lotus
leaves,
herein
study
has
presented
design
a
biomimetic
Janus
membrane
that
integrates
unidirectional
biofluid
drainage
photothermal‐enhanced
evaporation/sterilization
capabilities
for
accelerating
diabetic
healing.
This
prepared
electrospinning
polyacrylonitrile
(PAN)
nanofiber
containing
polydopamine
(PDA)
on
surface
polypropylene
(PP)
nonwoven
membrane.
Such
PP/PAN
x%PDA
enables
antigravity
“pumping”
water
from
hydrophobic
PP
layer
hydrophilic
PAN
within
22
s
through
contact
points
interface.
The
incorporation
30
wt%
PDA
in
imparts
high
photoabsorption
photothermal
responsiveness,
facilitating
continuous
volatilization
exudate,
achieving
twice
displacement
water,
causing
irreversible
damage
bacteria.
As
result,
it
effectively
alleviates
inflammation
cellular
fibrosis
while
promoting
collagen
deposition
due
its
structure
antibacterial
properties.
Impressively,
such
achieves
an
impressive
closure
rate
96.7%
wounds,
better
than
(59.8%)
conventional
bandages.
Therefore,
this
offers
promising
alternative
chronic
wounds.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 3849 - 3849
Опубликована: Март 29, 2024
This
state-of-the-art
review
explores
the
emerging
field
of
regenerative
hydrogels
and
their
profound
impact
on
treatment
skin
wounds.
Regenerative
hydrogels,
composed
mainly
water-absorbing
polymers,
have
garnered
attention
in
wound
healing,
particularly
for
Their
unique
properties
make
them
well
suited
tissue
regeneration.
Notable
benefits
include
excellent
water
retention,
creating
a
crucially
moist
environment
optimal
facilitating
cell
migration,
proliferation.
Biocompatibility
is
key
feature,
minimizing
adverse
reactions
promoting
natural
healing
process.
Acting
as
supportive
scaffold
growth,
mimic
extracellular
matrix,
aiding
attachment
proliferation
cells
like
fibroblasts
keratinocytes.
Engineered
controlled
drug
release,
enhance
by
angiogenesis,
reducing
inflammation,
preventing
infection.
The
demonstrated
acceleration
process,
beneficial
chronic
or
impaired
wounds,
adds
to
appeal.
Easy
application
conformity
various
shapes
practical,
including
irregular
challenging
areas.
Scar
minimization
through
regeneration
crucial,
especially
cosmetic
functional
regions.
Hydrogels
contribute
pain
management
protective
barrier,
friction,
fostering
soothing
environment.
Some
with
inherent
antimicrobial
properties,
aid
infection
prevention,
which
crucial
aspect
successful
healing.
flexibility
ability
conform
contours
ensure
contact,
enhancing
overall
effectiveness.
In
summary,
present
promising
approach
improving
outcomes
across
diverse
clinical
scenarios.
provides
comprehensive
analysis
benefits,
mechanisms,
challenges
associated
use
this
review,
authors
likely
delve
into
rational
design
principles
efficacy
performance
Through
an
exploration
methodologies
approaches,
paper
poised
highlight
how
these
been
instrumental
refining
potentially
revolutionizing
therapeutic
potential
addressing
By
synthesizing
current
knowledge
highlighting
avenues
future
research,
aims
advancement
medicine
ultimately
improve
patients
