Molecules,
Год журнала:
2024,
Номер
29(22), С. 5374 - 5374
Опубликована: Ноя. 14, 2024
Diabetic
foot
ulcers
(DFUs),
a
prevalent
chronic
disease
caused
by
various
factors,
significantly
impact
patients’
quality
of
life
due
to
prolonged
healing
times
and
increased
infection
risks.
Current
treatment
modalities,
including
pharmacological,
physical,
surgical
interventions,
often
yield
limited
efficacy
adverse
effects,
highlighting
the
urgent
need
for
novel
therapeutic
strategies.
The
objective
this
research
is
create
SIKVAV-modified
chitosan
hydrogels
with
intention
improving
process
skin
wound
in
diabetic
mice.
We
synthesized
established
mice
model
wounding
evaluate
its
effects
underlying
mechanisms.
results
our
study
indicate
that
markedly
enhance
This
effect
may
be
attributed
several
mechanisms,
differentiation
fibroblasts,
proliferation
keratinocytes,
promotion
angiogenesis,
stimulation
collagen
synthesis,
upregulation
growth
factor
expression,
possible
involvement
TGF-β1/Smad3
signaling
pathway.
not
only
provides
new
biomaterial
wounds
but
also
elucidates
related
molecular
mechanisms
involved
DFUs,
offering
valuable
insights
future
clinical
applications.
Bioactive Materials,
Год журнала:
2024,
Номер
41, С. 193 - 206
Опубликована: Июль 20, 2024
Regulating
macrophage
phenotypes
to
reconcile
the
conflict
between
bacterial
suppression
and
tissue
regeneration
is
ideal
for
treating
infectious
skin
wounds.
Here,
an
injectable
immunoregulatory
hydrogel
(SrmE20)
that
sequentially
drives
phenotypic
polarization
(M0
M1,
then
M2)
was
constructed
by
integrating
anti-inflammatory
components
proinflammatory
solvents.
Biomacromolecules,
Год журнала:
2024,
Номер
25(11), С. 7015 - 7057
Опубликована: Окт. 18, 2024
Biomedical
polymers
play
a
key
role
in
preventing,
diagnosing,
and
treating
diseases,
showcasing
wide
range
of
applications.
Their
unique
advantages,
such
as
rich
source,
good
biocompatibility,
excellent
modifiability,
make
them
ideal
biomaterials
for
drug
delivery,
biomedical
imaging,
tissue
engineering.
However,
conventional
suffer
from
poor
degradation
