Antioxidants,
Год журнала:
2024,
Номер
13(4), С. 417 - 417
Опубликована: Март 29, 2024
Radiation-induced
enteritis
is
an
unavoidable
complication
associated
with
pelvic
tumor
radiotherapy,
significantly
influencing
the
prognosis
of
cancer
patients.
The
limited
availability
commercial
gastrointestinal
radioprotectors
in
clinical
settings
poses
a
substantial
challenge
preventing
radiation
enteritis.
Despite
inherent
radioprotective
characteristics
Cur
vitro,
its
poor
solubility
water,
instability,
and
low
bioavailability
lead
to
inferior
therapeutic
effects
vivo.
Herein,
we
developed
novel
ROS-responsive
micelles
(CTI)
from
inulin
curcumin,
aimed
at
mitigating
CTI
had
excellent
stability.
Importantly,
improved
cytotoxicity
thereby
showing
enhanced
effectiveness
neutralizing
ROS
induced
by
radiation,
safeguarding
against
DNA
damage,
reducing
radiation-induced
cellular
mortality.
Moreover,
mice
model,
not
only
alleviated
severe
intestinal
injury
but
also
redox-related
indicators
reduced
inflammatory
cytokine
expression.
Furthermore,
effectively
increased
gut
microbiota
abundance
maintained
homeostasis.
In
conclusion,
could
be
promising
candidate
for
management
Our
study
provides
new
perspective
radioprotection
using
natural
antioxidants.
Pharmaceutics,
Год журнала:
2023,
Номер
15(10), С. 2514 - 2514
Опубликована: Окт. 23, 2023
Hydrogels
prepared
from
natural
polymer
have
attracted
extensive
attention
in
biomedical
fields
such
as
drug
delivery,
wound
healing,
and
regenerative
medicine
due
to
their
good
biocompatibility,
degradability,
flexibility.
This
review
outlines
the
commonly
used
hydrogel
preparation,
including
cellulose,
chitosan,
collagen/gelatin,
alginate,
hyaluronic
acid,
starch,
guar
gum,
agarose,
dextran.
The
polymeric
structure
process/synthesis
of
polymers
are
illustrated,
polymer-based
hydrogels
formation
properties
elaborated.
Subsequently,
applications
based
on
tissue
regeneration,
other
summarized.
Finally,
future
perspectives
them
discussed.
For
polymers,
novel
technologies
enzymatic
biological
methods
been
developed
improve
structural
properties,
development
new
natural-based
or
derivatives
with
high
performance
is
still
very
important
challenging.
hydrogels,
materials,
like
double-network
hydrogel,
multifunctional
composite
microrobots
designed
meet
advanced
requirements
applications,
strategies
dual-cross-linking,
microfluidic
chip,
micropatterning,
3D/4D
bioprinting
explored
fabricate
materials
for
applications.
Overall,
increasing
interest
strategies/methods
fabrication
highly
desirable
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(30)
Опубликована: Июль 22, 2024
Abstract
Due
to
repeated
microbial
infection,
persistent
inflammation,
excessive
oxidative
stress,
and
cell
dysfunction,
chronic
wounds
are
difficult
heal,
posing
a
serious
threat
public
health.
Therefore,
developing
multifunctional
wound
dressings
that
can
regulate
the
complex
microenvironment
of
enhance
cellular
function
holds
great
significance.
Recently,
chitosan
has
emerged
as
promising
biopolymer
for
healing
due
its
excellent
biocompatibility,
biodegradability,
versatile
bioactivity.
The
aim
this
review
is
provide
comprehensive
understanding
mechanisms
delayed
discuss
healing–promoting
properties
derivatives,
such
good
antibacterial
activity,
hemostatic
capacity,
ability
promote
tissue
regeneration.
On
basis,
potential
applications
chitosan‐based
hydrogels
summarized
in
healing,
including
providing
suitable
microenvironment,
eliminating
bacterial
infections,
promoting
hemostasis,
inhibiting
alleviating
In
addition,
concerns
perspectives
clinical
application
also
discussed.
Biomaterials Science,
Год журнала:
2024,
Номер
12(6), С. 1405 - 1424
Опубликована: Янв. 1, 2024
This
review
introduces
gallic-acid
hydrogels,
covering
their
crosslinking
mechanisms,
physicochemical
properties,
synthesis
methods,
and
biomedical
applications,
aiming
to
provide
inspiration
for
the
design
of
multifunctional
polyphenol
hydrogels.
