Materials Today Bio,
Год журнала:
2024,
Номер
30, С. 101434 - 101434
Опубликована: Дек. 28, 2024
Oral
squamous
cell
carcinoma
(OSCC)
remains
a
formidable
challenge
due
to
high
recurrence
rates
and
limited
efficacy
of
conventional
treatments.
Immunotherapy
holds
potential,
but
its
effectiveness
is
often
restricted
by
low
patient
responsiveness.
This
study
presents
novel
therapeutic
strategy
using
GSH/pH-responsive
copper-based
cascade
nanocomplexes
induce
immunogenic
death
(ICD)
in
OSCC.
The
fabricated
nanocomplex,
PC@B-H,
leverages
the
acidic
reducing
tumor
microenvironment
release
copper
ions
plumbagin,
triggering
mechanisms
including
cuproptosis,
ferroptosis,
necroptosis.
multifunctional
system
not
only
enhances
oxidative
stress
also
depletes
glutathione,
promotes
lipid
peroxidation,
disrupts
mitochondrial
function,
leading
robust
inhibition.
Additionally,
induction
ICD
facilitates
dendritic
maturation
cytotoxic
T
lymphocyte
infiltration,
providing
durable
anti-tumor
immunity.
demonstrates
that
PC@B-H
achieves
92.3
%
growth
inhibition
rate
with
minimal
systemic
toxicity,
offering
promising
avenue
for
enhancing
OSCC
treatment
through
combined
pathways
immune
activation.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(28)
Опубликована: Июль 12, 2024
The
synergistic
effect
of
apoptosis
and
cuproptosis,
along
with
the
activation
immune
system,
presents
a
promising
approach
to
enhance
efficacy
against
triple-negative
breast
cancer
(TNBC).
Here,
two
prodrugs
are
synthesized:
reactive
oxygen
species
(ROS)-responsive
prodrug
PEG-TK-DOX
glutathione
(GSH)-responsive
PEG-DTPA-SS-CPT.
These
self-assembled
chelated
Cu2+
prepare
nanoparticle
PCD@Cu
that
simultaneously
loaded
doxorubicin
(DOX),
camptothecin
(CPT),
Cu2+.
elevated
levels
ROS
GSH
in
TNBC
cells
disrupted
structure,
leading
release
Cu+,
DOX,
CPT
depletion
GSH.
DOX
triggered
immunogenic
cell
death
(ICD)
cells.
Simultaneously,
downregulated
expression
copper
transporting
ATPase
2
(ATP7B),
causing
significant
accumulation
ions
This
further
induced
aggregation
lipoylated
dihydrolipoamide
S-acetyltransferase
(DLAT)
downregulation
iron-sulfur
(Fe-S)
cluster
proteins,
ultimately
cuproptosis
ICD
TNBC.
In
vitro
vivo
experiments
confirmed
activated
demonstrating
strong
anti-tumor
capabilities.
Moreover,
exhibited
an
excellent
biosafety
profile.
Overall,
this
study
provides
strategy
for
effective
therapy.
Abstract
Hyaluronic
acid
(HA)
is
a
naturally
occurring
polysaccharide
found
in
the
extracellular
matrix
with
broad
applications
disease
treatment.
HA
possesses
good
biocompatibility,
biodegradability,
and
ability
to
interact
various
cell
surface
receptors.
Its
wide
range
of
molecular
weights
modifiable
chemical
groups
make
it
an
effective
drug
carrier
for
delivery.
Additionally,
overexpression
specific
receptors
on
surfaces
many
states
enhances
accumulation
drugs
at
pathological
sites
through
receptor
binding.
In
this
review,
modification
drugs,
major
proteins,
latest
advances
receptor‐targeted
nano
delivery
systems
(DDS)
treatment
tumors
inflammatory
diseases
are
summarized.
Furthermore,
functions
varying
vivo
selection
methods
different
discussed.
Normal
life
requires
cell
division
to
produce
new
cells,
but
death
is
necessary
maintain
balance.
Dysregulation
of
can
lead
the
survival
and
proliferation
abnormal
promoting
tumor
development.
Unlike
apoptosis,
necrosis,
autophagy,
newly
recognized
forms
regulated
(RCD)
cuproptosis,
ferroptosis,
PANoptosis
provide
novel
therapeutic
strategies
for
treatment.
Increasing
research
indicates
that
immune
cells
mediated
by
these
discovered
regulate
microenvironment
(TME)
influence
effectiveness
immunotherapy.
This
review
primarily
elucidates
molecular
mechanisms
their
complex
effects
on
TME.
also
summarizes
exploration
nanoparticle
applications
in
therapy
based
vivo
vitro
evidence
derived
from
induction
or
inhibition
RCD
pathways.
Breast Cancer Targets and Therapy,
Год журнала:
2024,
Номер
Volume 16, С. 347 - 358
Опубликована: Июль 1, 2024
Abstract:
In
recent
years,
more
and
researches
on
cell
death
mode
in
breast
cancer,
including
apoptosis,
ferroptosis,
etc.
Ferroptosisis
a
regulated
form
of
characterized
by
iron-dependent
accumulation
lipid
peroxidation
to
lethal
levels,
numerous
studies
have
shown
that
ferroptosis
is
closely
associated
with
tumor
cells.
Breast
cancer
one
the
malignant
tumors
highest
incidence
women,
TNBC
accounts
for
about
15–
20%
all
types
cancer.
Due
poor
prognosis,
strong
aggressiveness,
high
drug
resistance
lack
molecular
targeting
characteristics
TNBC,
treatment
faces
many
difficulties
great
challenges.
A
large
number
plays
an
important
role
occurrence
development
diagnosis,
among
which
main
mechanisms
inducing
include
oxidative
stress
pathway,
iron
metabolism
pathway
pathway.
Since
highly
sensitive
pathways,
intracellular
GSH
reduces
reactive
oxygen
species
under
action
peroxidase
(GPX),
when
(LPO)
accumulates
certain
level,
will
be
induced,
thus
achieving
purpose
killing
addition,
consistent
level
As
new
therapeutic
method,
nanotechnology
has
added
security
its
safety
excellent
biocompatibility.
Therefore,
combination
iron-based
radiotherapy,
chemotherapy,
immunization
research
value
novel
idea
treating
ethnopharmacology
combined
also
involved.
This
article
reviews
mechanism
prospects
based
nanotechnology,
hoping
provide
references
diseases
ferroptosis.
Keywords:
triple-negative
ACS Applied Nano Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 3, 2025
Developing
nanomedicines
with
simultaneous
diagnosis
and
treatment
functions
is
a
promising
therapeutic
strategy
for
cancer
therapy.
Herein,
multifunctional
manganese
oxide-mesoporous
carbon
nanoparticles
(MnOx-MCN
NPs)
were
designed
magnetic
resonance
imaging
(MRI)-guided
chemotherapy,
photothermal
therapy
(PTT),
chemodynamic
(CDT).
The
excellent
conversion
efficiency
(44.2%)
outstanding
fenton-like
catalytic
activity
endowed
MnOx-MCN
NPs
PTT/CDT
synergistic
Furthermore,
their
unique
mesoporous
structure,
can
also
act
as
drug
delivery
carrier
encapsulating
chemotherapy
agent
doxorubicin
(DOX).
mild
acid
tumor
microenvironment
(TME)
near-infrared
(NIR)
heat
induced
the
release
of
DOX.
In
addition,
NIR
laser
enhanced
CDT
NPs,
thus
generating
chemotherapy/PTT/CDT
effect.
Extracellular
experiments
demonstrated
that
generated
by
irradiation
could
encourage
generation
•OH.
More
importantly,
displayed
superior
anticancer
both
in
vitro
vivo.
Such
elaborately
synthesized
nanomaterial
provides
paradigm
design
other
multifunction
nanoagents.
