Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 19, 2024
Honokiol,
a
naturally
occurring
compound
from
Magnolia
obovata
Thunb
.,
has
many
biological
activities,
but
its
anti-α-glucosidase
activity
is
still
unclear.
Therefore,
we
determined
inhibitory
effects
against
α-glucosidase.
Activity
assays
showed
that
honokiol
was
reversible
mixed-type
inhibitor
of
α-glucosidase,
and
IC
50
value
317.11
±
12.86
μM.
Fluorescence
results
indicated
the
binding
to
α-glucosidase
caused
reduction
in
activity.
3D
fluorescence
CD
spectra
conformational
change
Docking
simulated
detailed
interactions
between
including
hydrogen
hydrophobic
bonds.
All
findings
could
be
used
as
natural
develop
agents.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
163, С. 114834 - 114834
Опубликована: Май 8, 2023
Osteoporosis
is
becoming
a
major
concern
in
the
field
of
public
health.
The
process
bone
loss
insidious
and
does
not
directly
induce
obvious
symptoms.
Complications
indicate
an
irreversible
decrease
mass.
high-risk
populations
osteoporosis,
including
postmenopausal
women,
elderly
men,
diabetic
patients
obese
individuals
need
regular
mineral
density
testing
appropriate
preventive
treatment.
However,
primary
changes
these
are
different,
increasing
difficulty
effective
treatment
osteoporosis.
Determining
core
pathogenesis
osteoporosis
helps
improve
efficiency
efficacy
among
populations.
Oxidative
stress
common
pathological
state
secondary
to
estrogen
deficiency,
aging,
hyperglycemia
hyperlipemia.
In
this
review,
we
divided
oxidative
into
direct
effect
reactive
oxygen
species
(ROS)
reduction
antioxidant
enzyme
activity
discuss
their
roles
development
ROS
initiated
mitochondrial
apoptotic
signaling
suppressed
osteogenic
marker
expression
weaken
osteogenesis.
MAPK
NF-κB
pathways
mediated
positive
on
osteoclast
differentiation.
Antioxidant
enzymes
only
eliminate
negative
effects
ROS,
but
also
participate
regulation
metabolism.
Additionally,
described
proinflammatory
factors
HIF-1α
under
pathophysiological
inflammation
hypoxia,
which
provided
supplement
stress-induced
conclusion,
our
review
showed
that
was
population
for
Targeted
would
greatly
optimize
therapeutic
schedule
various
treatments.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(6), С. 1824 - 1842
Опубликована: Янв. 1, 2024
In
this
review,
we
briefly
summarize
the
recent
research
progress
in
enantioselective
higher-order
cycloadditions,
focusing
on
preparation
of
medium-sized
and
multicyclic
chiral
molecules
by
metal-free
catalysis.
Journal of Materials Science Materials in Medicine,
Год журнала:
2023,
Номер
34(1)
Опубликована: Янв. 9, 2023
Magnesium
(Mg)
and
Selenium
(Se)
are
essential
elements
for
bone
health
have
been
studied
extensively
its
powerful
osteogenesis
promoting
regeneration.
The
purpose
was
to
observe
whether
Co-modified
3D-printed
β-tricalcium
phosphate
with
Mg
Se
could
promote
defect
regeneration
in
an
ovariectomized(OVX)
rat
model.
MC3T3-E1
cells
were
co-cultured
the
leachate
of
β-TCP,
Mg-TCP,
Mg/Se-TCP
induced
osteogenesis,
cell
viability,
ROS,
osteogenic
activity
observed
by
Cell
Count
Kit-8(CCK-8),
fluorescent
probe
2',
7'-dichlorofluorescin
diacetate,
Alkaline
phosphatase
(ALP)
staining,
Alizarin
Red(RES)
western
blotting(WB),
immunofluorescence.
Then
implanted
into
femoral
epiphysis
model
OVX
rats
12
weeks.
Micro-CT
histology
analysis
used
therapeutic
effect.
In
vitro
results
show
that
mineralization
group
is
significantly
higher
than
β-TCP
Mg-TCP
group.
Protein
expressions
such
as
FOxO1,
SIRT1,
SOD2,
Runx-2,
Cola1a,
OC
Con
intracellular
ROS
SIRT1
SOD2
immunofluorescence
showed
can
restore
oxidative
stress
balance
osteoblasts.
treatment
largest
amount
tissue
area
(p
<
0.05),
exhibited
lower
values
residual
biological
material
compared
Our
research
confirm
improve
function
osteoblasts
enhance
mediated
reducing
models.
release
during
degradation
local
repair
ability.
At
same
time,
it
also
inhibit
ultimately
greatly
repair.
Journal of drug targeting,
Год журнала:
2025,
Номер
unknown, С. 1 - 41
Опубликована: Янв. 2, 2025
In
recent
years,
the
use
of
traditional
Chinese
medicine
(TCM)
in
treatment
cancer
has
received
widespread
attention.
Treatment
tumours
using
TCM
can
effectively
reduce
side
effects
anti-tumour
drugs,
meanwhile
to
improve
efficacy
patients.
However,
most
active
ingredients
TCM,
such
as
saponins,
alkaloids,
flavonoids,
volatile
oils,
etc.,
have
defects
low
bioavailability
and
poor
solubility
clinical
application,
which
seriously
restrict
application
TCM.
Meanwhile,
encapsulation
into
lipid
nano-delivery
systems
for
therapy
much
Lipid
are
obtained
by
phospholipids
base
material
adding
other
auxiliary
materials
under
a
certain
preparation
process,
including,
example,
liposomes,
solid
nanoparticles
(SLNs),
nanostructured
carriers
(NLCs),
microemulsions,
self-microemulsion
drug
delivery
(SMEDDS),
resolve
problems
improving
reducing
toxicity
drugs.
This
paper
focuses
on
categories,
development
status,
research
progress
nano
system
aiming
provide
theoretical
basis
further
in-depth
rational
these
systems.
Frontiers in Plant Science,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 7, 2025
Silybum
marianum
is
a
medicinal
plant
that
produces
silymarin,
which
has
been
demonstrated
to
possess
antiviral,
anti-neurodegenerative,
and
anticancer
activities.
Silybin
(A+B)
are
two
major
hepatoprotective
flavonolignans
produced
predominantly
in
S.
fruits.
Several
attempts
have
made
increase
the
synthesis
of
or
its
primary
components,
silybin
(A+B).
Zinc
oxide
nanoparticles
(ZnO-NPs)
considered
highly
efficient
Zn
source
widely
used
promote
crop
development
productivity.
In
this
study,
we
aimed
investigate
effects
foliar
application
ZnO-NPs
on
growth,
yield,
photosynthetic
pigment
content,
expression
chalcone
synthase
(CHS)
gene
plants.
Different
concentrations
were
administered
as
sprays
plants
growing
greenhouse
conditions.
Furthermore,
evaluated
anti-osteoporotic
efficacy
corresponding
fruit
extract
against
dexamethasone
(Dex)-induced
osteoporosis.
Foliar
treatment
at
all
ZnO-NP
increased
amounts
bioactive
components
(A+B),
enhanced
growth
yield
while
increasing
levels
N,
P,
K,
their
leaves,
roots,
fruits;
pigments
leaves;
content
fruits,
thereby
value
marianum.
The
highest
gains
observed
sprayed
with
concentration
(20.0
mg/L).
addition,
studies
revealed
stimulated
production
by
activating
CHS
genes.
administration
extracts
Dex-administered
rats
osteoblast
bone
formation
inhibiting
osteoclast
resorption,
protecting
animals
Dex-induced
Cell Communication and Signaling,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 11, 2025
The
prevalence
of
obesity
and
osteoporosis
(OP)
represents
a
significant
public
health
concern
on
global
scale.
A
substantial
body
evidence
indicates
that
there
is
complex
relationship
between
OP,
with
correlation
the
occurrence
OP
obesity.
In
recent
years,
sirtuins
have
emerged
as
prominent
area
interest
in
fields
aging
endocrine
metabolism.
Among
various
research
avenues
exploring
potential
sirtuins,
effects
these
proteins
garnered
attention
from
numerous
researchers.
Sirtuins
regulate
energy
balance
lipid
balance,
which
turn
inhibit
process
adipogenesis.
Additionally,
osteogenic
osteoblastic
activity,
protects
against
development
OP.
However,
no
study
has
yet
provided
comprehensive
discussion
three:
obesity,
This
paper
will
therefore
describe
focusing
possibility
treating
caused
by
targeting
sirtuins.
be
based
common
influences
(such
mesenchymal
stem
cells,
gut
microbiota,
insulin).
Finally,
SIRT1,
an
important
member
polyphenolic
natural
products
for
treatment
presented.
contribute
to
better
understanding
interactions
bone,
facilitate
new
therapeutic
strategies
future.
