Oxidative stress: A common pathological state in a high-risk population for osteoporosis

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 163, P. 114834 - 114834

Published: May 8, 2023

Osteoporosis is becoming a major concern in the field of public health. The process bone loss insidious and does not directly induce obvious symptoms. Complications indicate an irreversible decrease mass. high-risk populations osteoporosis, including postmenopausal women, elderly men, diabetic patients obese individuals need regular mineral density testing appropriate preventive treatment. However, primary changes these are different, increasing difficulty effective treatment osteoporosis. Determining core pathogenesis osteoporosis helps improve efficiency efficacy among populations. Oxidative stress common pathological state secondary to estrogen deficiency, aging, hyperglycemia hyperlipemia. In this review, we divided oxidative into direct effect reactive oxygen species (ROS) reduction antioxidant enzyme activity discuss their roles development ROS initiated mitochondrial apoptotic signaling suppressed osteogenic marker expression weaken osteogenesis. MAPK NF-κB pathways mediated positive on osteoclast differentiation. Antioxidant enzymes only eliminate negative effects ROS, but also participate regulation metabolism. Additionally, described proinflammatory factors HIF-1α under pathophysiological inflammation hypoxia, which provided supplement stress-induced conclusion, our review showed that was population for Targeted would greatly optimize therapeutic schedule various treatments.

Language: Английский

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Investigation on the inhibition mechanism and binding behavior of cryptolepine to α-glucosidase and its hypoglycemic activity by multi-spectroscopic method

Journal of Luminescence, Journal Year: 2024, Volume and Issue: 269, P. 120437 - 120437

Published: Jan. 3, 2024

Language: Английский

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Thiazolidine-2,4-dione derivatives as potential α-glucosidase inhibitors: Synthesis, inhibitory activity, binding interaction and hypoglycemic activity

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 144, P. 107177 - 107177

Published: Feb. 6, 2024

Language: Английский

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Recent advances in metal-free catalytic enantioselective higher-order cycloadditions

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(6), P. 1824 - 1842

Published: Jan. 1, 2024

In this review, we briefly summarize the recent research progress in enantioselective higher-order cycloadditions, focusing on preparation of medium-sized and multicyclic chiral molecules by metal-free catalysis.

Language: Английский

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Parabacteroides goldsteinii enriched by Pericarpium Citri Reticulatae ‘Chachiensis’ polysaccharides improves colitis via the inhibition of lipopolysaccharide-involved PI3K-Akt signaling pathway

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 133726 - 133726

Published: July 31, 2024

Language: Английский

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Astaxanthin prevents bone loss in osteoporotic rats with palmitic acid through suppressing oxidative stress

Redox Report, Journal Year: 2024, Volume and Issue: 29(1)

Published: April 16, 2024

Objectives The study aimed to assess the role of Astaxanthin (ATX) in palmitic acid(PA) -induced bone loss Ovariectomized(OVX) rats.

Language: Английский

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Co-modified 3D printed β-tricalcium phosphate with magnesium and selenium promotes bone defect regeneration in ovariectomized rat

Journal of Materials Science Materials in Medicine, Journal Year: 2023, Volume and Issue: 34(1)

Published: Jan. 9, 2023

Magnesium (Mg) and Selenium (Se) are essential elements for bone health have been studied extensively its powerful osteogenesis promoting regeneration. The purpose was to observe whether Co-modified 3D-printed β-tricalcium phosphate with Mg Se could promote defect regeneration in an ovariectomized(OVX) rat model. MC3T3-E1 cells were co-cultured the leachate of β-TCP, Mg-TCP, Mg/Se-TCP induced osteogenesis, cell viability, ROS, osteogenic activity observed by Cell Count Kit-8(CCK-8), fluorescent probe 2', 7'-dichlorofluorescin diacetate, Alkaline phosphatase (ALP) staining, Alizarin Red(RES) western blotting(WB), immunofluorescence. Then implanted into femoral epiphysis model OVX rats 12 weeks. Micro-CT histology analysis used therapeutic effect. In vitro results show that mineralization group is significantly higher than β-TCP Mg-TCP group. Protein expressions such as FOxO1, SIRT1, SOD2, Runx-2, Cola1a, OC Con intracellular ROS SIRT1 SOD2 immunofluorescence showed can restore oxidative stress balance osteoblasts. treatment largest amount tissue area (p < 0.05), exhibited lower values residual biological material compared Our research confirm improve function osteoblasts enhance mediated reducing models. release during degradation local repair ability. At same time, it also inhibit ultimately greatly repair.

Language: Английский

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Review on anti-tumor lipid nano drug delivery systems of traditional Chinese medicine

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 41

Published: Jan. 2, 2025

In recent years, the use of traditional Chinese medicine (TCM) in treatment cancer has received widespread attention. Treatment tumours using TCM can effectively reduce side effects anti-tumour drugs, meanwhile to improve efficacy patients. However, most active ingredients TCM, such as saponins, alkaloids, flavonoids, volatile oils, etc., have defects low bioavailability and poor solubility clinical application, which seriously restrict application TCM. Meanwhile, encapsulation into lipid nano-delivery systems for therapy much Lipid are obtained by phospholipids base material adding other auxiliary materials under a certain preparation process, including, example, liposomes, solid nanoparticles (SLNs), nanostructured carriers (NLCs), microemulsions, self-microemulsion drug delivery (SMEDDS), resolve problems improving reducing toxicity drugs. This paper focuses on categories, development status, research progress nano system aiming provide theoretical basis further in-depth rational these systems.

Language: Английский

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Foliar spraying with zinc oxide nanoparticles enhances the anti-osteoporotic efficacy of the fruit extracts of Silybum marianum L. by stimulating silybin production

Frontiers in Plant Science, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

Silybum marianum is a medicinal plant that produces silymarin, which has been demonstrated to possess antiviral, anti-neurodegenerative, and anticancer activities. Silybin (A+B) are two major hepatoprotective flavonolignans produced predominantly in S. fruits. Several attempts have made increase the synthesis of or its primary components, silybin (A+B). Zinc oxide nanoparticles (ZnO-NPs) considered highly efficient Zn source widely used promote crop development productivity. In this study, we aimed investigate effects foliar application ZnO-NPs on growth, yield, photosynthetic pigment content, expression chalcone synthase (CHS) gene plants. Different concentrations were administered as sprays plants growing greenhouse conditions. Furthermore, evaluated anti-osteoporotic efficacy corresponding fruit extract against dexamethasone (Dex)-induced osteoporosis. Foliar treatment at all ZnO-NP increased amounts bioactive components (A+B), enhanced growth yield while increasing levels N, P, K, their leaves, roots, fruits; pigments leaves; content fruits, thereby value marianum. The highest gains observed sprayed with concentration (20.0 mg/L). addition, studies revealed stimulated production by activating CHS genes. administration extracts Dex-administered rats osteoblast bone formation inhibiting osteoclast resorption, protecting animals Dex-induced

Language: Английский

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Role of sirtuins in obesity and osteoporosis: molecular mechanisms and therapeutic targets

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 11, 2025

The prevalence of obesity and osteoporosis (OP) represents a significant public health concern on global scale. A substantial body evidence indicates that there is complex relationship between OP, with correlation the occurrence OP obesity. In recent years, sirtuins have emerged as prominent area interest in fields aging endocrine metabolism. Among various research avenues exploring potential sirtuins, effects these proteins garnered attention from numerous researchers. Sirtuins regulate energy balance lipid balance, which turn inhibit process adipogenesis. Additionally, osteogenic osteoblastic activity, protects against development OP. However, no study has yet provided comprehensive discussion three: obesity, This paper will therefore describe focusing possibility treating caused by targeting sirtuins. be based common influences (such mesenchymal stem cells, gut microbiota, insulin). Finally, SIRT1, an important member polyphenolic natural products for treatment presented. contribute to better understanding interactions bone, facilitate new therapeutic strategies future.

Language: Английский

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