Poultry Science,
Год журнала:
2024,
Номер
103(11), С. 104217 - 104217
Опубликована: Авг. 14, 2024
Trimethyltin
chloride
(TMT)
is
widespread
in
the
environment
and
harmful
to
both
humans
animals.
In
order
investigate
toxicity
mechanism
of
TMT
exposure
on
chicken
liver,
We
established
an
vivo
experimental
model
by
giving
chickens
oral
administration
different
concentrations
dilution
solution
vitro
experiments
treating
leghorn
male
hepatoma
(LMH)
cells
for
12
h.
The
results
showed
that
Albumin
(ALB),
total
protein
(TP)
alanine
aminotransferase
(ALT)
blood
TMT-treated
chickens,
as
well
ALT
aspartate
(AST)
were
dose-dependently
increased,
degrees
necrosis
hepatocytes
observed
histology.
Meanwhile,
led
a
significant
decrease
glutathione
(GSH)
content
liver
tissues
LMH
cells,
what's
more
increase
malondialdehyde
(MDA)
cell
supernatants.
expression
apoptosis-related
genes
Caspase8,
Caspase3
Caspase9
increased
after
treated
TMT,
percentage
late
apoptosis
cells.
This
suggests
can
cause
oxidative
stress
livers
resulting
injury.
