Oncogene,
Год журнала:
2024,
Номер
43(31), С. 2389 - 2404
Опубликована: Июнь 18, 2024
The
role
of
tumor-resident
microbiota
in
modulating
tumor
immunity
remains
unclear.
Here,
we
discovered
an
abundance
intra-tumoral
bacteria,
such
us
E.coli,
residing
and
resulting
Colorectal
cancer
liver
metastasis
(CRLM).
E.coli
enhanced
lactate
production,
which
mediated
M2
macrophage
polarization
by
suppressing
nuclear
factor-κB
-gene
binding
(NF-κB)
signaling
through
retinoic
acid-inducible
gene
1
(RIG-I)
lactylation.
Lactylation
RIG-I
suppressed
recruitment
NF-κB
to
the
Nlrp3
promoter
macrophages,
thereby
reducing
its
transcription.
This
loss
affected
immunosuppressive
activities
regulatory
T
cells
(Tregs)
antitumor
CD8
Journal of Cancer Research and Clinical Oncology,
Год журнала:
2024,
Номер
150(5)
Опубликована: Май 7, 2024
Abstract
Background
Tumor
growth
is
closely
linked
to
the
activities
of
various
cells
in
tumor
microenvironment
(TME),
particularly
immune
cells.
During
progression,
circulating
monocytes
and
macrophages
are
recruited,
altering
TME
accelerating
growth.
These
adjust
their
functions
response
signals
from
stromal
Tumor-associated
(TAMs),
similar
M2
macrophages,
key
regulators
TME.
Methods
We
review
origins,
characteristics,
TAMs
within
This
analysis
includes
mechanisms
through
which
facilitate
evasion
promote
metastasis.
Additionally,
we
explore
potential
therapeutic
strategies
that
target
TAMs.
Results
instrumental
mediating
malignant
behaviors.
They
release
cytokines
inhibit
effector
attract
additional
immunosuppressive
primarily
T
cells,
inducing
exhaustion
directly,
influencing
activity
indirectly
cellular
interactions,
or
suppressing
checkpoints.
directly
involved
proliferation,
angiogenesis,
invasion,
Summary
Developing
innovative
tumor-targeted
therapies
immunotherapeutic
currently
a
promising
focus
oncology.
Given
pivotal
role
evasion,
several
approaches
have
been
devised
them.
include
leveraging
epigenetics,
metabolic
reprogramming,
engineering
repolarize
TAMs,
inhibiting
recruitment
activity,
using
as
drug
delivery
vehicles.
Although
some
these
remain
distant
clinical
application,
believe
future
targeting
will
offer
significant
benefits
cancer
patients.
Annual Review of Immunology,
Год журнала:
2023,
Номер
41(1), С. 73 - 98
Опубликована: Апрель 26, 2023
Characterization
of
RNA
modifications
has
identified
their
distribution
features
and
molecular
functions.
Dynamic
changes
in
modification
on
various
forms
are
essential
for
the
development
function
immune
system.
In
this
review,
we
discuss
value
innovative
profiling
technologies
to
uncover
these
diverse,
dynamic
cells
within
healthy
diseased
contexts.
Further,
explore
our
current
understanding
mechanisms
whereby
aberrant
modulate
milieu
tumor
microenvironment
point
out
outstanding
research
questions.
Abstract
RNA
methylation,
a
prevalent
post-transcriptional
modification,
has
garnered
considerable
attention
in
research
circles.
It
exerts
regulatory
control
over
diverse
biological
functions
by
modulating
splicing,
translation,
transport,
and
stability.
Notably,
studies
have
illuminated
the
substantial
impact
of
methylation
on
tumor
immunity.
The
primary
types
encompass
N6-methyladenosine
(m6A),
5-methylcytosine
(m5C),
N1-methyladenosine
(m1A),
N7-methylguanosine
(m7G),
3-methylcytidine
(m3C).
Compelling
evidence
underscores
involvement
regulating
microenvironment
(TME).
By
affecting
translation
stability
through
"writers",
"erasers"
"readers",
influence
dysregulation
immune
cells
factors.
Consequently,
plays
pivotal
role
immunity
mediating
various
behaviors,
encompassing
proliferation,
invasion,
metastasis,
etc.
In
this
review,
we
discussed
mechanisms
several
methylations,
providing
comprehensive
overview
their
roles
underlying
within
among
immunocytes.
exploring
how
these
modifications
mediate
evasion,
also
examine
potential
applications
immunotherapy.
This
review
aims
to
provide
novel
insights
strategies
for
identifying
targets
advancing
cancer
immunotherapy
efficacy.
Frontiers in Immunology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 29, 2024
Tumor-associated
macrophages
(TAMs)
are
present
in
almost
all
solid
tumor
tissues.
16They
play
critical
roles
immune
regulation,
angiogenesis,
stem
cell
activation,
invasion
and
metastasis,
resistance
to
therapy.
However,
it
is
unclear
how
TAMs
perform
these
functions.
With
the
application
of
single-cell
RNA
sequencing
(scRNA-seq),
has
become
possible
identify
TAM
subpopulations
associated
with
distinct
In
this
review,
we
discuss
four
novel
tumors
based
on
core
gene
signatures
by
scRNA-seq,
including
FCN1
+
,
SPP1
C1Q
CCL18
TAMs.
Functional
enrichment
expression
scRNA-seq
data
from
different
tissues
found
that
may
induce
inflammation;
potentially
involved
cancer
whereas
participate
regulation
suppression;
And
cells
terminal
immunosuppressive
not
only
have
a
stronger
function
but
also
enhance
metastasis.
can
be
further
divided
into
populations
Meanwhile,
will
emerging
evidence
highlighting
separating
macrophage
there
exist
potential
disconnects
between
types
identified
their
actual
function.
Oncogene,
Год журнала:
2024,
Номер
43(31), С. 2389 - 2404
Опубликована: Июнь 18, 2024
The
role
of
tumor-resident
microbiota
in
modulating
tumor
immunity
remains
unclear.
Here,
we
discovered
an
abundance
intra-tumoral
bacteria,
such
us
E.coli,
residing
and
resulting
Colorectal
cancer
liver
metastasis
(CRLM).
E.coli
enhanced
lactate
production,
which
mediated
M2
macrophage
polarization
by
suppressing
nuclear
factor-κB
-gene
binding
(NF-κB)
signaling
through
retinoic
acid-inducible
gene
1
(RIG-I)
lactylation.
Lactylation
RIG-I
suppressed
recruitment
NF-κB
to
the
Nlrp3
promoter
macrophages,
thereby
reducing
its
transcription.
This
loss
affected
immunosuppressive
activities
regulatory
T
cells
(Tregs)
antitumor
CD8
