The role of tumor-associated macrophages in tumor immune evasion

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(5)

Published: May 7, 2024

Abstract Background Tumor growth is closely linked to the activities of various cells in tumor microenvironment (TME), particularly immune cells. During progression, circulating monocytes and macrophages are recruited, altering TME accelerating growth. These adjust their functions response signals from stromal Tumor-associated (TAMs), similar M2 macrophages, key regulators TME. Methods We review origins, characteristics, TAMs within This analysis includes mechanisms through which facilitate evasion promote metastasis. Additionally, we explore potential therapeutic strategies that target TAMs. Results instrumental mediating malignant behaviors. They release cytokines inhibit effector attract additional immunosuppressive primarily T cells, inducing exhaustion directly, influencing activity indirectly cellular interactions, or suppressing checkpoints. directly involved proliferation, angiogenesis, invasion, Summary Developing innovative tumor-targeted therapies immunotherapeutic currently a promising focus oncology. Given pivotal role evasion, several approaches have been devised them. include leveraging epigenetics, metabolic reprogramming, engineering repolarize TAMs, inhibiting recruitment activity, using as drug delivery vehicles. Although some these remain distant clinical application, believe future targeting will offer significant benefits cancer patients.

Language: Английский

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The role of RNA methylation in tumor immunity and its potential in immunotherapy

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: June 20, 2024

Abstract RNA methylation, a prevalent post-transcriptional modification, has garnered considerable attention in research circles. It exerts regulatory control over diverse biological functions by modulating splicing, translation, transport, and stability. Notably, studies have illuminated the substantial impact of methylation on tumor immunity. The primary types encompass N6-methyladenosine (m6A), 5-methylcytosine (m5C), N1-methyladenosine (m1A), N7-methylguanosine (m7G), 3-methylcytidine (m3C). Compelling evidence underscores involvement regulating microenvironment (TME). By affecting translation stability through "writers", "erasers" "readers", influence dysregulation immune cells factors. Consequently, plays pivotal role immunity mediating various behaviors, encompassing proliferation, invasion, metastasis, etc. In this review, we discussed mechanisms several methylations, providing comprehensive overview their roles underlying within among immunocytes. exploring how these modifications mediate evasion, also examine potential applications immunotherapy. This review aims to provide novel insights strategies for identifying targets advancing cancer immunotherapy efficacy.

Language: Английский

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Tumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation

Oncogene, Journal Year: 2024, Volume and Issue: 43(31), P. 2389 - 2404

Published: June 18, 2024

The role of tumor-resident microbiota in modulating tumor immunity remains unclear. Here, we discovered an abundance intra-tumoral bacteria, such us E.coli, residing and resulting Colorectal cancer liver metastasis (CRLM). E.coli enhanced lactate production, which mediated M2 macrophage polarization by suppressing nuclear factor-κB -gene binding (NF-κB) signaling through retinoic acid-inducible gene 1 (RIG-I) lactylation. Lactylation RIG-I suppressed recruitment NF-κB to the Nlrp3 promoter macrophages, thereby reducing its transcription. This loss affected immunosuppressive activities regulatory T cells (Tregs) antitumor CD8

Language: Английский

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Novel tumor-associated macrophage populations and subpopulations by single cell RNA sequencing

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 29, 2024

Tumor-associated macrophages (TAMs) are present in almost all solid tumor tissues. 16They play critical roles immune regulation, angiogenesis, stem cell activation, invasion and metastasis, resistance to therapy. However, it is unclear how TAMs perform these functions. With the application of single-cell RNA sequencing (scRNA-seq), has become possible identify TAM subpopulations associated with distinct In this review, we discuss four novel tumors based on core gene signatures by scRNA-seq, including FCN1 + , SPP1 C1Q CCL18 TAMs. Functional enrichment expression scRNA-seq data from different tissues found that may induce inflammation; potentially involved cancer whereas participate regulation suppression; And cells terminal immunosuppressive not only have a stronger function but also enhance metastasis. can be further divided into populations Meanwhile, will emerging evidence highlighting separating macrophage there exist potential disconnects between types identified their actual function.

Language: Английский

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Helicobacter pylori reduces METTL14-mediated VAMP3 m6A modification and promotes the development of gastric cancer by regulating LC3C-mediated c-Met recycling

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 18, 2025

Helicobacter pylori (H. pylori) plays an important role in the malignant transformation of gastric mucosa from chronic inflammation to cancer. However, mechanisms underlying epigenetic regulation carcinogenesis mediated by H. remain unclear. Here, we uncover that inhibits METTL14 upregulating ATF3. cancer (GC) cell proliferation and metastasis vitro vivo. Downregulation Vesicle-associated membrane protein-3 (VAMP3) reducing m6A modification level VAMP3 mRNA stability IGF2BP2-dependent mRNA. also accelerates progression GC regulating VAMP3/LC3C-mediated c-Met recycling. Moreover, expression Hp+ gastritis tissues is much lower than Hp- tissues. levels are downregulated notably cancerous patients with GC. Therefore, our results show a novel METTL14-VAMP3-LC3C-c-Met signalling axis development infection, which reveals mechanism for provides potential prognostic biomarkers progression.

Language: Английский

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