Immunosenescence promotes cancer development: from mechanisms to treatment strategies

Cell Communication and Signaling, Год журнала: 2025, Номер 23(1)

Опубликована: Март 10, 2025

The body's innate immune system plays a pivotal role in identifying and eliminating cancer cells. However, as the ages, its functionality can deteriorate, becoming dysfunctional, inefficient, or even inactive—a condition referred to immunosenescence. This decline significantly increases risk of malignancies. While pro-cancer effects T-cell aging have been widely explored, there remains notable gap literature regarding impact on cells, such macrophages neutrophils. review seeks address this gap, with emphasis these cell types. Furthermore, although certain immunotherapies, including checkpoint inhibitors (ICIs), demonstrated efficacy across broad spectrum cancers, elderly patients are less likely derive clinical benefit from treatments. In some cases, they may experience immune-related adverse events (irAEs). senolytic strategies shown promise exerting anti-cancer effects, their reactions potential off-target present significant challenges. aims elucidate immunosenescence, implications for safety ICIs, anti-aging treatment strategies. addition, optimizing therapies minimize enhance therapeutic outcomes critical focus future research endeavors. Senescence is an inevitable phenomenon human body, scientists explored specific mechanisms by which immunosenescence advances development cancer. summarizes characteristics be used level surveillance cancers due "Targeting immunosenescence" new idea strategy therapy.

Язык: Английский

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Natural product/diet-based regulation of macrophage polarization: Implications in treatment of inflammatory-related diseases and cancer

The Journal of Nutritional Biochemistry, Год журнала: 2024, Номер 130, С. 109647 - 109647

Опубликована: Апрель 10, 2024

Язык: Английский

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LPS-induced senescence of macrophages aggravates calcification and senescence of vascular smooth muscle cells via IFITM3

Renal Failure, Год журнала: 2024, Номер 46(2)

Опубликована: Июль 8, 2024

Background Cellular senescence, macrophages infiltration, and vascular smooth muscle cells (VSMCs) osteogenic transdifferentiation participate in the pathophysiology of calcification chronic kidney disease (CKD). Senescent are involved regulation inflammation pathological diseases. In addition, senescent spread senescence to neighboring via Interferon-induced transmembrane protein3 (IFITM3). However, role IFITM3 VSMCs remains unexplored.

Язык: Английский

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Senescence as a therapeutic target in cancer and age-related diseases

Nature Reviews Drug Discovery, Год журнала: 2024, Номер 24(1), С. 57 - 71

Опубликована: Ноя. 15, 2024

Язык: Английский

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Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages

Nature Aging, Год журнала: 2023, Номер 3(10), С. 1251 - 1268

Опубликована: Сен. 18, 2023

Язык: Английский

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